The key to saving lives is to achieve instant and effective sealing hemostasis in the event of emergency bleeding. Herein, a plant oil-based EMTA/Zn2+ bioadhesive is prepared by a facile reaction of epoxidized soybean oil (ESO) with methacrylic acid (MAA) and tannic acid (TA), followed by the addition of zinc ions for coordination with TA. The EMTA/Zn2+ bioadhesive can be rapidly cured in situ at the wound site through photo-cross-linking under ultraviolet (UV) light-emitting diode (LED) irradiation within 30 s, achieving ultrastrong wet-tissue adhesion performance of 92.4 and 51.8 kPa to porcine skin and aortic skin after 7 days underwater, respectively. Especially, the EMTA/Zn2+ bioadhesive exhibits outstanding sealing performance in vitro with the high burst pressure of 525 mmHg (70 kPa) and 337.5 mmHg (45 kPa) to porcine skin and aortic skin, respectively. Moreover, the EMTA/Zn2+ bioadhesive not only has outstanding hemocompatibility and good biodegradability but also exhibits excellent cytocompatibility and antibacterial properties. Notably, the EMTA/Zn2+ bioadhesive has remarkable instant sealing hemostatic ability for hemorrhaging liver in vivo. Therefore, the prepared plant oil-based EMTA/Zn2+ bioadhesive can serve as a charming alternative candidate for instant sealing hemostasis in clinical applications, especially in traumatic internal organs and arterial bleeding.

10.1021/acsami.4c07517

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Citations (2)

The Teaching Reform of Course Practice of qEnterprise Imageq Based on New Media Application

Proceedings of the 2018 International Conference on Sports, Arts, Education and Management Engineering (SAEME 2018) (2018)

Chunyue Zhao

This paper is oriented by advertising design characteristics under new media application, and focuses on students' training of innovative ability and practice ability, studies how to make the " Enterprise Image " course meet the new requirements of the television, mobile phone and other emerging media on design idea, expression forms, media, and objects, and brings new media communications and applications into teaching, explores how to make full use of design laboratory resources and out-of-school practice base resources, builds course system and teaching system which are centered on the new media application.

Course (navigation)

10.2991/saeme-18.2018.103

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Investigation of Chrysin Inhibition on Free Radical Photopolymerization During the Preparation of Nanogels Under Green Led Irradiation

SSRN Electronic Journal (2022)

Hongxiang Li Chunyue Zhao Zhen Wang Jinfeng Xing

The application of drug-loaded nanogels in the treatment of cancer has attracted much attention. Here, the nanogels loaded with chrysin in situ were prepared and the effect of chrysin in the polymerization reaction was investigated. The morphology, chemical structure, and drug-polymer interactions of the nanogels loaded with chrysin (NG-C) were studied. Meanwhile, the time of gel point appearance, Uv-absorbance of eosin as a function of reaction time, double bond conversion, and monomer conversion of the system as a function of time were also evaluated.

Chrysin

Green-light

10.2139/ssrn.4255054

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Temperature/pH-responsive carmofur-loaded nanogels rapidly prepared via one-pot laser-induced emulsion polymerization

Colloids and Surfaces B Biointerfaces (2022)

Xinjing Du Yuanyuan Peng Chunyue Zhao Jinfeng Xing

Nanogel

Dispersity

Emulsion polymerization

Biocompatibility