I.V. Silva

Polytechnic Institute of Viseu

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A.G. Lopes

Universidade Federal do Rio de Janeiro

L.B.A. Rangel

Universidade Federal do Rio de Janeiro

Lucienne S. Lara

Universidade Federal do Rio de Janeiro

Celso Caruso‐Neves

Universidade Federal do Rio de Janeiro

Rafaela Salgado Ferreira

Universidade Federal de Minas Gerais

Cláudia Elias Duarte

Polytechnic Institute of Viseu

M.M. Oliveira

Universidade Federal de Mato Grosso do Sul

Francisco Graça

Polytechnic Institute of Viseu

Marcelo Einicker‐Lamas

Universidade Federal do Rio de Janeiro

Maria Escudeiro

Universidade do Porto

Cooperative Institutions

Universidade Federal do Rio de Janeiro

Polytechnic Institute of Viseu

Instituto de Biofísica Carlos Chagas Filho

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

National Institute of Science and Technology for Structural Biology and Bioimaging

Czech Academy of Sciences, Institute of Biophysics

National Institute of Science and Technology in Regenerative Medicine

Fundação Carlos Chagas

University of Lisbon

Universidade de São Paulo

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Nanopartículas no tratamento da doença de alzheimer

DOAJ (DOAJ: Directory of Open Access Journals) (2022)

Luísa Cruz‐Lopes Ana Isabel Lopes Maria Escudeiro Cláudia Elias Duarte Rafaela Salgado Ferreira

10.29352/mill0210e.26245

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ClC-5 chloride channel and kidney stones: what is the link?

Brazilian Journal of Medical and Biological Research (2001)

I.V. Silva Marcelo M. Morales A.G. Lopes

Nephrolithiasis is one of the most common diseases in the Western world. The disease manifests itself with intensive pain, sporadic infections, and, sometimes, renal failure. The symptoms are due to the appearance of urinary stones (calculi) which are formed mainly by calcium salts. These calcium salts precipitate in the renal papillae and/or within the collecting ducts. Inherited forms of nephrolithiasis related to chromosome X (X-linked hypercalciuric nephrolithiasis or XLN) have been recently described. Hypercalciuria, nephrocalcinosis, and male predominance are the major characteristics of these diseases. The gene responsible for the XLN forms of kidney stones was cloned and characterized as a chloride channel called ClC-5. The ClC-5 chloride channel belongs to a superfamily of voltage-gated chloride channels, whose physiological roles are not completely understood. The objective of the present review is to identify recent advances in the molecular pathology of nephrolithiasis, with emphasis on XLN. We also try to establish a link between a chloride channel like ClC-5, hypercalciuria, failure in urine acidification and protein endocytosis, which could explain the symptoms exhibited by XLN patients.

Nephrocalcinosis

Chloride channel

10.1590/s0100-879x2001000300004

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PI-PLCβ is involved in the modulation of the proximal tubule Na+-ATPase by angiotensin II

Regulatory Peptides (2004)

L.B.A. Rangel A.G. Lopes Lucienne S. Lara Thaís Louise Gurjão de Carvalho I.V. Silva

Tubule

10.1016/j.regpep.2004.12.007

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Citations (37)