Ewa Widy‐Tyszkiewicz

Medical University of Warsaw

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Agnieszka Piechal

Institute of Psychiatry and Neurology

Kamilla Blecharz‐Klin

Medical University of Warsaw

Justyna Pyrzanowska

Medical University of Warsaw

Ilona Joniec‐Maciejak

Medical University of Warsaw

Dagmara Mirowska-Guzeł

Medical University of Warsaw

Adriana Wawer

Medical University of Warsaw

Andrzej Członkowski

Medical University of Warsaw

Katarzyna Jawna‐Zboińska

Medical University of Warsaw

İC

İoanna Chinou

National and Kapodistrian University of Athens

Kinga Krzysztoforska

Medical University of Warsaw

Cooperative Institutions

Medical University of Warsaw

Polish Academy of Sciences

Institute of Psychiatry and Neurology

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego

University of Warsaw

University of Zurich

Poznan University of Medical Sciences

Warsaw University of Technology

Mossakowski Medical Research Institute, Polish Academy of Sciences

Wojskowy Instytut Higieny i Epidemiologii

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Interakcje lekow roslinnych stosowanych w chorobach ukladu pokarmowego

Justyna Pyrzanowska Agnieszka Piechal Kamilla Blecharz‐Klin Ewa Widy‐Tyszkiewicz

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Citations (2)

Cerebellar level of neurotransmitters in rats exposed to paracetamol during development

Pharmacological Reports (2016)

Kamilla Blecharz‐Klin Ilona Joniec‐Maciejak Katarzyna Jawna‐Zboińska Justyna Pyrzanowska Agnieszka Piechal

Pharmacotherapy

10.1016/j.pharep.2016.06.005

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Citations (20)

Aspalathus linearis infusion affects hole-board test behaviour and amino acid concentration in the brain

Neuroscience Letters (2021)

Justyna Pyrzanowska Ilona Joniec‐Maciejak Kamilla Blecharz‐Klin Agnieszka Piechal Dagmara Mirowska-Guzeł

Neurochemical

Elevated plus maze

10.1016/j.neulet.2021.135680

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Citations (7)

Maternal Zinc Supplementation Improves Spatial Memory in Rat Pups

Biological Trace Element Research (2012)

Agnieszka Piechal Kamilla Blecharz‐Klin Justyna Pyrzanowska Ewa Widy‐Tyszkiewicz

A large body of evidence supports an opinion that adequate dietary zinc is essential for prenatal and postnatal brain development. Behavioural effects of maternal supplementation with ZnSO4 were analysed in rat pups with the Morris water task performance, a hole board and a T-maze. Wistar females during pregnancy and lactation received a drinking water solution of ZnSO4 at doses of 16 mg/kg (group Zn16) or 32 mg/kg (group Zn32). Behavioural tests were conducted on the 4-week-old male rat pups. Zinc concentration in the serum, hippocampus and prefrontal cortex of offsprings was determined by means of atomic absorption techniques. The Newman–Keuls multiple comparison test revealed an increase of climbing in the Zn16 group in comparison to the control group (Con) and the Zn32 group during the hole board test. ANOVA for repeated measures showed a significant memory improvement in both supplemented groups compared to the control in the probe trial on day 5 of the water maze test. ZnSO4 treatment significantly elevated zinc levels in the rat serum. Follow-up data on brain content of zinc in the hippocampus revealed significant differences between the groups and in supplemented groups correlated with crossings above the original platform position. These findings suggest that pre- and postnatal zinc supplementation may improve cognitive development in rats.

Water maze

10.1007/s12011-012-9323-y

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Citations (33)

Effect of aliphatic monoamines on motor activity of mice: no direct interaction with dopaminergic D2 receptor.

PubMed (1983)

Ewa Widy‐Tyszkiewicz Andrzej Członkowski

The effect of butylamine, pentylamine and hexylamine on spontaneous locomotor activity of mice was evaluated in the presence or absence of drugs affecting monoaminergic neurons. Pentylamine and hexylamine produced similar effects (stimulation after low, inhibition after high doses), while butylamine action was weak. Depression of locomotor activity produced by combined treatment with alpha-methyl-tyrosine, reserpine and dopa was counteracted by pentylamine and hexylamine; they did not produce such an effect in the absence of dopa. The amines did not displace 3H-spiperone specifically bound to striatal membranes.

Monoaminergic

Reserpine

Butylamine

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Determination of Mechanical Properties of Rat Aorta Using Ring-Shaped Specimen

Diffusion and defect data, solid state data. Part B, Solid state phenomena/Solid state phenomena (2015)

Michał Kowalik Justyna Pyrzanowska Agnieszka Piechal Kamilla Blecharz‐Klin Ewa Widy‐Tyszkiewicz

Ring-shaped specimen is commonly used in tests for determination of mechanical properties for arteries in hoop direction, especially for small mammals such as rats or mice. Although ring test is a lot more convenient than the tests concerning strip specimens, interpretation of the experimental data might be inconclusive – it is difficult distinguish whether it's still straightening up or the actual tension begins. The basic problem is to properly define initial length of specimen, which is essential for strain calculation. The purpose of this study was to evaluate various methods for strain evaluation. Ten Wistar Albino Glaxo male rats (3 months old, body weight about 200g) were sacrificed by decapitation and arteries were immediately removed. Three specimens, each approximately 2–3mm long, from each rat were excised adjacent to the aortic arch. Couple different initial lengths, as well as Digital Image Correlation based extensometer results were used for strain-stress response calculations. In addition a 3D Finite Element model, with an Ogden constitutive model based material, was made for deeper investigation of specimen behavior. This study has shown that the testing procedure for determination of mechanical properties of arteries, based on ring-shaped specimen, is prone to errors. Stiffness calculations are very sensitive to the choice of initial length of the specimen. As the use of DIC proved to give very good correlation with experimental data this method will be used in further studies.

Extensometer

Ogden

Digital image correlation

Strain (injury)

Tension (geology)

Uniaxial tension

10.4028/www.scientific.net/ssp.240.255

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Current Evidence for Disease Prevention and Treatment by Protocatechuic Acid (PCA) and Its Precursor Protocatechuic Aldehyde (PCAL) in Animals and Humans

Reference series in phytochemistry (2021)

Ewa Widy‐Tyszkiewicz

Protocatechuic acid

10.1007/978-3-030-45299-5_36-1

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Long-term consumption of rooibos herbal tea affects hypothalamic neurotransmission and social behavior of adult Sprague–Dawley male rats

European Food Research and Technology (2024)

Justyna Pyrzanowska Ilona Joniec‐Maciejak Adriana Wawer Ewa Machaj Kamilla Blecharz‐Klin

Abstract Abundant in phenolic compounds, “fermented” rooibos herbal tea (FRHT) improves the cognitive performance and exploration of rats, as well as alters the content of monoamines and amino acids in some brain structures. Here, we aim to extend knowledge about the neurochemical and behavioral outcomes of long-term oral FRHT consumption by examining its impact on hypothalamus functions. FRHTs of different leaf-to-water ratios were given to adult male SD rats for 3 months. Their behavior was evaluated in social interaction test. The concentration of hypothalamic monoamines and amino acids was analyzed by HPLC-ECD whereas BDNF/TrkB by Elisa method. It was shown that sustained FRHT consumption did not affect aggression of the rats but was able to increase social deficits, expressed as diminished total time of contact and shorter active social interaction. Upon biochemical investigation, the changes were primarily linked to serotonergic, glutaminergic, and BDNF/TrkB pathway. Decreased 5-HT and TrkB content in the hypothalamus could be linked with social deficits and suggested positive effect on central energy balance, yet the main body mass of animals in the experiment remained unaffected. On the other hand, the reduced hypothalamic serotonin signaling anticipated the influence on hypothalamic–pituitary–adrenal axis and possible diminution of plasma corticosterone level with subsequent behavioral aftermath and lower obesity risk. Our research contributes toward better understanding of the mechanism of action of rooibos tea and its effects within the central nervous system. Graphical abstract

Neurochemical

10.1007/s00217-023-04434-3

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Citations (2)

NORMOTENSIVE WISTAR RATS DIFFER FROM SPONTANEOUSLY HYPERTENSIVE AND RENAL HYPERTENSIVE RATS IN THEIR CARDIOVASCULAR RESPONSES TO OPIOID AGONISTS

Clinical and Experimental Pharmacology and Physiology (1991)

Ewa Widy‐Tyszkiewicz Andrzej Członkowski

SUMMARY 1. The effects of three opioid receptor agonists on the blood pressure and heart rate of anaesthetized normotensive, spontaneously hypertensive and renal hypertensive rats were measured. 2. Mu agonist morphiceptin i.c.v. induced a pressor response and increase in heart rate in hypertensive rats, but hypotension in normotensive rats. After intravenous (i.v.) injection, morphiceptin produced a hypotensive response in all three groups of rats. 3. In contrast, the delta agonist DTLET i.c.v. decreased blood pressure and heart rate in hypertensive rats, but increased both pressure and beat rate in normotensive rats. After i.v. injections DTLET produced a hypertensive response and increase in heart rate in all groups of rats. 4. Kappa agonist U‐50, 488H given i.c.v. induced effects similar to morphiceptin: an increase in blood pressure and heart rate in hypertensive and a decrease in normotensive rats. After i.v. injections U‐50, 488H produced decreases in blood pressure and heart rate in all treated groups of rats. 5. Pretreatment with naloxone antagonized the activity of morphiceptin but prevented only the stimulating effect of DTLET in normotensive rats. Cardiovascular actions of U‐50, 488H were not blocked by naloxone. 6. The results suggest that opioid agonists exert similar changes in cardiovascular function at central and peripheral sites in both models of experimental hypertension and these effects are different in normotensive rats.

Spontaneously hypertensive rat

10.1111/j.1440-1681.1991.tb01398.x

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Citations (9)

Pharmacological and biochemical effects of Ginkgo biloba extract on learning, memory consolidation and motor activity in old rats

Acta Neurobiologiae Experimentalis (2009)

Kamilla Blecharz‐Klin Agnieszka Piechal Ilona Joniec‐Maciejak Justyna Pyrzanowska Ewa Widy‐Tyszkiewicz

Effect of administration of the standardized extract of Ginkgo biloba leaves (EGb 761) on learning, memory and exploratory behavior was estimated in water maze and hole-board tests. Rats (18-month old) received for three months EGb 761 at doses: 50, 100 and 150 mg/kg b.w. per day. After completion of the behavioral experiment, concentrations of neurotransmitters were estimated in selected brain regions. ANOVA demonstrated significant differences in the content of monoamines and metabolites between the treatment groups compared to the control. The increased level of 5-hydroxytryptamine (5-HT) in the hippocampus and 5-HIAA (5-HT metabolite) in the prefrontal cortex correlated positively with the retention of spatial memory. Positive correlation between platform crossings in SE during the probe trial and neurotransmitter turnover suggest improvement of spatial memory. Long-term administration of Ginkgo biloba extract can improve spatial memory and motivation with significant changes in the content and metabolism of monoamines in several brain regions.

Memory improvement

Ginkgoales

10.55782/ane-2009-1747

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Citations (60)