F. O. Eschbach

Motorola (United States)

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Samuel J. Huang

Marshfield Clinic

Luigi Ambrosio

Institute of Polymers, Composites and Biomaterials

Mariarosa Anna Beatrice Melone

University of Campania "Luigi Vanvitelli"

L. Nicolais

University of Naples Federico II

A. Anani

Motorola (United States)

Vernon Meadows

Motorola (United States)

Orsolina Petillo

National Research Council

Shengjie Huang

Hunan University

Gianfranco Peluso

Saint Camillus International University of Health and Medical Sciences

Jason N. Howard

University College Dublin

Cooperative Institutions

National Research Council

Motorola (United States)

University of Naples Federico II

Institute of Biosciences and Bioresources

University of Connecticut

Institute of Polymers, Composites and Biomaterials

Case Western Reserve University

Cornell University

National Academies of Sciences, Engineering, and Medicine

University of Campania "Luigi Vanvitelli"

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Hydrophilic—Hydrophobic Interpenetrating Polymer Networks and Semi-interpenetrating Polymer Networks

Advances in chemistry series (1994)

F. O. Eschbach Shengjie Huang

Poly(2-hydroxyethyl methacrylate) (PHEMA) in the water-swollen state is a very soft hydrogel with high water content. Therefore, it is similar to natural tissues and is widely used as a biomaterial. Unfortunately, PHEMA hydrogels have low mechanical strength and tear resistance. The incorporation of hydrophobic polycaprolactone (PCL) improves the mechanical properties of the swollen networks and preserves their biocompatibility. Three ways to combine PHEMA and PCL were investigated. Semi-interpenetrating polymer networks of PHEMA and low molecular weight PCL diol were prepared. Interpenetrating polymer networks of PHEMA and high molecular weight PCL were synthesized using two different methods depending upon the relative composition (PHEMA:PCL). Mechanical, thermal, and swelling properties were investigated.

Polycaprolactone

Interpenetrating polymer network

Biocompatibility

Biomaterial

10.1021/ba-1994-0239.ch009

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Citations (18)

Impedance effects of rechargeable batteries on digital communication devices

Electrochimica Acta (1995)

A. Anani F. O. Eschbach Jason N. Howard F. Malaspina Vernon Meadows

Output impedance

10.1016/0013-4686(95)00165-b

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Citations (5)

The differential effects of poly(2-hydroxyethyl methacrylate) and poly(2-hydroxyethyl methacrylate)/ poly(caprolactone) polymers on cell proliferation and collagen synthesis by human lung fibroblasts

Journal of Biomedical Materials Research (1997)

Gianfranco Peluso Orsolina Petillo J. M. Anderson Luigi Ambrosio L. Nicolais

Because of its chemical versatility and demonstrated biocompatibility, poly(2-hydroxyethyl methacrylate) (pHEMA) has been widely used as a polymer for biomedical applications. Since this hydrophilic material shows a poor interface with cells, blendings with other polymers were done to improve cytocompatibility. In our polymer, the presence of hydrophobic dominions on the material surface, due to the interpenetrating polymerization of pHEMA with poly(caprolactone) (PCL), seems to ameliorate the cytocompatibility in terms of cell adhesion and metabolism. For our experiments, we used IMR-90 human fibroblasts, as these cells strongly regulate DNA, RNA, and protein synthesis as anchorage-dependent variables. Cell attachment on a pHEMA/PCL interpenetrating polymer network was optimal, suggesting a strong adhesion between the cells and the polymer surface. Cell adhesion was weaker on pHEMA, as a significant fraction of the fibroblasts revealed a lack of spreading, with most cells remaining spherical. Moreover, only fibroblasts seeded on pHEMA significantly decreased mRNA synthesis; collagen production and cell shapes ranged from fully flat and proliferating, to minimally spread and nonproliferating. Finally, DNA synthesis, as a measure of cell proliferation, was markedly inhibited in cells cultured on pHEMA but not on pHEMA/PCL. In conclusion, our results suggest that control of cell growth and metabolism by biomedical polymers is based on physicochemical mechanism(s) in which the hydrophilicity/hydrophobicity ratio of the material surfaces may play an important role. © 1997 John Wiley & Sons, Inc.

Biocompatibility

2-Hydroxyethyl Methacrylate

Caprolactone

Biomaterial

10.1002/(sici)1097-4636(19970305)34:3<327::aid-jbm7>3.0.co;2-m

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Citations (43)