Jinmin Zhang

Lanzhou Jiaotong University

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Weifeng Yu

Renji Hospital

Wei Dong

First People's Hospital of Yunnan Province

Jiankun Yu

China Medical University

Pingtian Ding

Shenzhen Technology University

Haonan Xing

National Center for Nanoscience and Technology

Weiping Zhou

Shenyang Medical College

Tianzhi Yang

Northeast Normal University

Hui Liu

Lanzhou University

Cuifang Cai

Fujian Research Institute of Light Industry

Feixiang Wu

Guangxi Medical University

Cooperative Institutions

Chinese Academy of Sciences

103

University of Chinese Academy of Sciences

Peking University

Sun Yat-sen University

Huazhong University of Science and Technology

Second Military Medical University

Zhejiang University

Shanghai Jiao Tong University

Eastern Hepatobiliary Surgery Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

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Competitive Inhibition of the Nondepolarizing Muscle Relaxant Rocuronium on Nicotinic Acetylcholine Receptor Channels in the Rat Superior Cervical Ganglia

Journal of Cardiovascular Pharmacology (2013)

Chengmi Zhang Zhenmeng Wang Jinmin Zhang Haibo Qiu Yuming Sun

A number of case reports now indicate that rocuronium can induce a number of serious side effects. We hypothesized that these side effects might be mediated by the inhibition of nicotinic acetylcholine receptors (nAChRs) at superior cervical ganglion (SCG) neurons. Conventional patch clamp recordings were used to study the effects of rocuronium on nAChR currents from enzymatically dissociated rat SCG neurons. We found that ACh induced a peak transient inward current in rat SCG neurons. Additionally, rocuronium suppressed the peak ACh-evoked currents in rat SCG neurons in a concentration-dependent and competitive manner, and it increased the extent of desensitization of nAChRs. The inhibitory rate of rocuronium on nAChR currents did not change significantly at membrane potentials between -70 and -20 mV, suggesting that this inhibition was voltage independent. Lastly, rocuronium preapplication enhanced its inhibitory effect, indicating that this drug might prefer to act on the closed state of nAChR channels. In conclusion, rocuronium, at clinically relevant concentrations, directly inhibits nAChRs at the SCG by interacting with both opened and closed states. This inhibition is competitive, dose dependent, and voltage independent. Blockade of synaptic transmission in the sympathetic ganglia by rocuronium might have potentially inhibitory effects on the cardiovascular system.

Superior cervical ganglion

Cervical ganglia

Neuromuscular transmission

10.1097/fjc.0000000000000063

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Alterations of actin cytoskeleton and arterial protein level in patients with obstructive jaundice

Figshare (2022)

Hong‐Qian Wang Xiao‐Yan Meng Jinmin Zhang Jiaying Chen Baohua Zhang

Abstract Vascular hypo-responsiveness to vasopressors in patients with obstructive jaundice (OJ) is a common anesthetic event, which leads to perioperative complications and increased mortality. The cause of this clinical issue remains unclear. In this study, we estimated the actin cytoskeleton and arterial protein level in the artery of OJ patients by proteomic analysis. Ten patients with OJ due to bile duct diseases or pancreatic head carcinoma were enrolled, while another ten non-jaundice patients with chronic cholecystitis or liver hemangioma as the control group. Vascular reactivity to noradrenaline was measured before anesthesia on the day of surgery. Artery samples in adjacent tissues of removed tumor were collected and evaluated by 2-dimensional electrophoresis. Proteins with differential expression were detected by MALDI-TOF mass spectrometry with immunoblot confirmation. The results confirmed the phenomenon of vascular hypo-reactivity in OJ patients as suppressed aortic response to noradrenaline were existed in these patients. We also found that actin cytoskeleton and several actin-binding proteins were up- or down-regulated in the artery of OJ patients. These proteins changed in OJ patents might be the basic mechanism of vascular hypo-reactivity, further studies to uncover the role of these proteins in OJ is critical for clinical treatment of these patients.

Obstructive jaundice

10.6084/m9.figshare.21087428

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The Application and Practice of Matlab in Solid State Physics Teaching

Tinghong Gao Xuechen Hu Jinmin Zhang

With the development of the education, computer technology plays an important role in modern teaching. It is helpful for students to learn better about both the crystal and amorphous structures in Solid State Physics course by introducing the Matlab software for teaching aid tool. In this paper, Matlab software is applied to show the crystal cells and the microstructural models. Based on the 3D visualization technology, crystal cells and sectional drawings can rotate around X, Y and Z axes and be cut freely and be viewed from different perspectives. The teaching practice shows that this method can stimulate students' participation, increase interests in learning and finally improve the teaching effect. The new technology is helpful for students to explore microstructures of materials and enhance the application and practice of computer technology.

Crystal (programming language)

10.1145/3134847.3134853

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Quantitative measurements of IR780 in formulations and tissues

Journal of Pharmaceutical and Biomedical Analysis (2020)

Jianmei Wang Jinmin Zhang Ngoc Thao Duyen Nguyen Yu‐An Chen Jer‐Tsong Hsieh

10.1016/j.jpba.2020.113780

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Topological and Semantic Map Generation for Mobile Robot Indoor Navigation

Lecture notes in computer science (2021)

Yujing Chen Jinmin Zhang Yunjiang Lou

Topological map

Grid reference

Semantic mapping

10.1007/978-3-030-89095-7_33

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THE EXPRESSIONS OF TS AND TP AND THEIR SIGNIFICANCE IN SQUAMOUS CELL CARCINOMA OF THE CERVIX BEFORE AND AFTER CHEMOTHERAPY

Acta Academiae Medicinae Qingdao Universitatis (2013)

Jinmin Zhang

Objective To study the expressions of TS and TP in squamous carcinoma(SC) of the cervix-before and after arterial chemoembolization-and their clinical significance.Methods Immunohistochemical method was employed to detect the expressions of TS and TP in cancer tissue of 40 patients with SC of the cervix and normal tissue of the cervix in 20 cases,the association of expressions of TS and TP with therapeutic efficacy was analyzed.Results After chemotherapy,the expressions of TS and TP decreased significantly(χ2=4.377,7.200;P0.05),which were negatively correlated with the chemotherapeutic efficacy(r=-0.500,-0.449;P0.05).Conclusion he changes of TS and TP expression are closely related with the occurrence of SC of the cervix,which is of a certain value in guiding therapy and predicting prognosis of this malignancy.

Clinical Significance

Squamous carcinoma

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SURGICAL MANAGEMENT FOR RECURRENT NASOPHARYNGEAL CARCINOMA (NPC) AFTER IRRADIATION

Chinese Journal of Cancer (1989)

Jinmin Zhang

Neck dissection

Fenestration

Cervical lymph nodes

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A study on the growth kinetics of CeO2-modified aluminide coating and its computer fitting

Materials Science and Engineering A (2008)

Jiuba Wen Yang Liu-song Limin Zhu Jinmin Zhang Quanan Li

Aluminide

Cementation (geology)

Deposition

10.1016/j.msea.2007.11.139

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Extraction and Content Measurement of Oligosaccharide from Capparis spinosa

Jinmin Zhang

Objective:To measure the content of oligosaccharide from Capparis spinosa, extraction technological parameters were studied. Method: The effects of temperature, time, solid-liquid ratio, the ethanol solution concen-tration on the extraction rate of oligosaccharide were investigated by single factor test and orthogonal experiments. The content of oligosaccharide was determined by ultraviolet spectrophotometry. Result: The four influence factors were extraction timeextraction temperaturethe ethanol solution concentrationsolid-liquid ratio in turn. The optimum technological parameters were established: 70℃ of extracting temperature, 70min of he-ating time, solid-liquid ratio 1/25, the ethanol solution concentration was 80%. Under this condition, the extraction rate of oligosacc-haride was measured about 3.70%. Conclusion: The results provided scientific foundation for the further research.

Oligosaccharide

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MOLECULAR VOLUMES OF SALTS. WITH TRIANGULAR RADICALS

Science China Chemistry (1990)

Jinmin Zhang Danian Ye

Additive function

Ionic radius

10.1360/yb1990-33-4-485

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