Katsumasa Sato

Fukuyama Cardiovascular Hospital

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Antonio Colombo

EMO GVM Centro Cuore Columbus

Haruaki Tomioka

Shimane University

Azeem Latib

Montefiore Medical Center

Hajime Saito

Iwate Medical University

Tadashi Miyazaki

Juntendo University

Toru Naganuma

New Tokyo Hospital

Vasileios F. Panoulas

Guy's and St Thomas' NHS Foundation Trust

Hiromi Tomioka

Kobe City Medical Center West Hospital

Toshiaki Shimizu

Juntendo University

Chiaki Sano

Shimane University

Cooperative Institutions

Shimane University

Fukuyama Cardiovascular Hospital

Okayama University

The University of Tokyo

Kumamoto University

San Raffaele University of Rome

Istituti di Ricovero e Cura a Carattere Scientifico

Fukushima Medical University

Kyoto University

Nagoya University

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Evaluation of BACTEC 460 TB System for Measurement of In Vitro Anti-Mycobacterium leprae Activity of Various Antimicrobials

Nihon Raigakkai zasshi/Nihon Rai Gakkai zasshi (1992)

Haruaki Tomioka Hajime Saito Katsumasa Sato

諸種抗菌剤のin vitro抗M. leprae活性をBACTEC460 TB Systemを用いて測定した。本システムは,7H12B液体培地中に含まれる[14C]パルミチン酸から菌の増殖あるいは代謝によって産生される14CO2を測定し,被検菌のGrowth Index (0～999)を求めるものであるが,この培地中へのclofazimine, KRM-1648, rifabutin, clarithromycin及びrifampicinの添加により薬剤非添加対照におけるGrowth Indexに比べ85～98%と高度の抑制がみられた。また,sparfloxacin, minocycline, ofloxacin, ciprofloxacin, fleroxacin及びDDSでは21～48%と中程度の阻害作用が認められたが,他方amikacin, pipemidic acid, piromidic acid, enoxacin及びnorfloxacinにはそのような抗菌活性はみられなかった。BACTEC法で測定されたこれら薬剤のin vitro抗M. leprae活性は,マウスfoot pad感染モデル系を用いて判定されたin vivo抗らい活性と極めてよく相関することから,本システムは,諸種抗菌剤の抗M. leprae活性のスクリーニングに有用であると思われる。

Clofazimine

Rifabutin

Pefloxacin

Fleroxacin

Mycobacterium leprae

Sparfloxacin

Enoxacin

Amikacin

10.5025/hansen1977.61.157

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Citations (3)

[Effects of the Chinese traditional medicines "mao-bushi-saishin-to" and "yokuinin" on the antimycobacterial activity of murine macrophages against Mycobacterium avium complex infection].

PubMed (1999)

Toshiaki Shimizu Chiaki Sano Tatsuya Akaki K. Ogasawara Katsumasa Sato

We previously examined the effects of two Chinese traditional medicines "Mao-Bushi-Saishin-To" (MBST) and "Yokuinin", on the therapeutic efficacies of a benzoxazinorifamycin, KRM-1648, against Mycobacterium avium complex (MAC) infection induced in mice. MBST but not Yokuinin potentiated the therapeutic activity of KRM-1648 against MAC infection. In the present study, we examined the effects of these traditional medicines on some M phi cell functions. First, MBST significantly potentiated M phi anti-MAC antimicrobial activity, while Yokuinin did so to a much lesser extent. Secondly, MBST and Yokuinin each strongly inhibited production of nitric oxide (NO) in MAC-infected M phi s. Thirdly, treatment of M phi s with MBST or Yokuinin caused reductions in the accumulation of IL-10 in culture fluids by MAC-infected M phi s during the first 2-days cultivation. On the other hand, in the separate experiment, treatment of M phi s with these drugs caused no significant change in the accumulation of TGF-beta by MAC-infected M phi s at day 7. These findings suggest that these Chinese traditional medicines, particularly MBST, potentiate M phi anti-MAC antimicrobial activity, however, NO do not appear to be crucial effectors in the anti-MAC activity of MBST- or Yokuinin-treated M phi s. Moreover, MBST- and Yokuinin-mediated down-regulation of the production of IL-10 in MAC-infected M phi s may be related to their potentiating effects on M phi anti-MAC activity.

Antimycobacterial

Mycobacterium avium complex

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Citations (2)

In vitro susceptibility of Mycobacterium fortuitum complex to cephem antibiotics.

PubMed (1985)

Hajime Saito Katsumasa Sato

Mycobacterium fortuitum

Cephem

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Citations (1)

The diagnosis of intermediate coronary artery stenosis by myocardial perfusion imaging using an ultrafast cardiac gamma camera: Comparison with fractional flow reserve

International Journal of Cardiology (2016)

Kenji Goto Hideo Takebayashi Hiroki Yamane Arata Hagikura K Kobayashi

Cadmium zinc telluride

Fractional Flow Reserve

Gamma camera

Coronary flow reserve

10.1016/j.ijcard.2016.02.114

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Citations (2)

Clinical outcomes following bioresorbable scaffold implantation in small vessels

International Journal of Cardiology (2016)

Akihito Tanaka Neil Ruparelia Hiroyoshi Kawamoto Alessandro Sticchi Katsumasa Sato

Bioresorbable scaffold

10.1016/j.ijcard.2016.01.005

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Citations (2)

TCT-694 Early Outcomes With Direct Flow Medical Versus 1°-Generation Transcatheter Aortic Valve Devices: A Single-Center Propensity-Matched Analysis

Journal of the American College of Cardiology (2014)

Gennaro Giustino Azeem Latib Vasileios F. Panoulas Matteo Montorfano Alaide Chieffo

Single Center

10.1016/j.jacc.2014.07.766

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TCT-250 A Comparison of Cobalt-Chromium Alloy Stents: Zotarolimus-eluting and Everolimus-eluting in Patients with Diabetes

Journal of the American College of Cardiology (2014)

Tadashi Miyazaki Azeem Latib Vasileios F. Panoulas Katsumasa Sato Hiroyoshi Kawamoto

Zotarolimus

Everolimus

10.1016/j.jacc.2014.07.290

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[Identification of Mycobacterium avium and Mycobacterium intracellulare using three DNA probe tests, and their distributions in Japan].

PubMed (1991)

Haruaki Tomioka Katsumasa Sato Hajime Saito H Tasaka

Identification of Mycobacterium avium complex (MAC) was made using three DNA probe tests for MAC: Gen-Probe Rapid Diagnostic System for the MAC (Gen-Probe Inc., San Diego, U.S.A.), AccuProbe MAC Culture Identification or Confirmation Test (Gen-Probe Inc.); and SNAP Culture Identification Diagnostic Kit (MAC) (Syngene Inc., San Diego, U.S.A.). Various strains of MAC belonging to serovars 21 to 28 were identified by the DNA probe tests and showed the following. First, Serovar 21 and 25 belonged to M. avium and M. intracellulare, respectively. Each of them reacted with species-specific probes used in the three DNA probe tests [i.e., either M. avium-probe (in SNAP test; Probe A) or M. intracellulare-probe (in SNAP test; Probe I)]. Second, serovars 22-24 and 26-28 consisted of M. intracellulare, MAC strains that reacted with Probe X of SNAP test but lacked the reactivity with M. avium- and M. intracellulare probes of all the DNA probe tests, M. scrofulaceum that showed no reactivity with M. avium- or M. intracellulare-probe or Probe X, and M. scrofulaceum that had only the reactivity with Probe X. When the disease-associated MAC strains (35 strains), isolated in the Kanto to Kyushu areas in Japan, were identified using AccuProbe test, both the M. avium and M. intracellulare strains identified by the Gen-Probe test reacted with the MAC-probe but not with the M. tuberculosis complex (MTC)-probe.(ABSTRACT TRUNCATED AT 250 WORDS)

Hybridization probe

Molecular probe

Mycobacterium avium-intracellulare infection

Mycobacterium avium complex

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Citations (4)

Two cases of idiopathic pulmonary fibrosis evaluated by dynamic digital radiography for diaphragmatic motion and disease progression

Respirology Case Reports (2024)

Takefumi Nikaido Yoshinori Tanino Yuki Sato Ryuichi Togawa Takaya Kawamata

Abstract Forced vital capacity has been utilized as a parameter of disease progression in idiopathic pulmonary fibrosis (IPF); however, its measurement is difficult when patients do not understand or cooperate. Dynamic digital radiography (DDR) enables sequential chest X‐ray imaging during breathing, with lower radiation doses compared to conventional fluoroscopy or computed tomography. There is accumulating evidence showing that parameters obtained from DDR, particularly those related to diaphragmatic dynamics, are correlated with pulmonary function parameters, and are useful for pathophysiological evaluation. We herein present two cases that suggest parameters obtained from DDR during supine normal tidal breathing may predict disease progression of IPF.

Supine position

10.1002/rcr2.1301

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Citations (1)

THE EFFECT OF MACROPHAGE ACCUMULATIONS ON BARE–METAL STENT NEOINTIMA IN PATIENTS WITH ACUTE CORONARY SYNDROME: EVALUATION USING OPTICAL COHERENCE TOMOGRAPHY

Journal of the American College of Cardiology (2013)

Yuetsu Kikuta Hideo Takebayashi Shigeki Hiramatsu Manabu Taniguchi Kenji Goto

Neointima

Bare-metal stent

10.1016/s0735-1097(13)61786-6

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Citations (0)