Chenjiao Zhang

Bengbu Medical College

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Jingchao Hu

Capital Medical University

Jianrong Du

Hunan Institute of Science and Technology

Li Zhao

The First Hospital of Kunming

Hanxue Zhao

Capital Medical University

Huanqin Gao

Beijing HuiLongGuan Hospital

Jing Chen

Peking University

Zhixiang Peng

Education University of Hong Kong

Yanhong Luo

Bengbu Medical College

Jun-Hui Feng

Beijing HuiLongGuan Hospital

Zhao Han

Lanzhou University

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Beijing HuiLongGuan Hospital

Peking University

Capital Medical University

Harbin Medical University

Guangdong Provincial People's Hospital

First Affiliated Hospital of Harbin Medical University

Nanjing University of Aeronautics and Astronautics

Peking University Sixth Hospital

Sun Yat-sen University

Shanghai Jiao Tong University

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A large-scale study on uric acid-related biomarkers in patients with bipolar disorder

Psychiatry Research (2024)

Huanqin Gao Chenjiao Zhang Jun-Hui Feng Yanhong Luo Tingting Wang

10.1016/j.psychres.2024.116089

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Citations (1)

Chitosan Hydrogel-Delivered ABE8e Corrects PAX9 Mutant in Dental Pulp Stem Cells

Gels (2023)

Bowen Liu Chenjiao Zhang Hanxue Zhao Jian Gao Jingchao Hu

Hypodontia (dental agenesis) is a genetic disorder, and it has been identified that the mutation C175T in PAX9 could lead to hypodontia. Cas9 nickase (nCas9)-mediated homology-directed repair (HDR) and base editing were used for the correction of this mutated point. This study aimed to investigate the effect of HDR and the base editor ABE8e in editing PAX9 mutant. It was found that the chitosan hydrogel was efficient in delivering naked DNA into dental pulp stem cells (DPSCs). To explore the influence of the C175T mutation in PAX9 on the proliferation of DPSCs, hydrogel was employed to deliver PAX9 mutant vector into DPSCs, finding that the PAX9-containing C175T mutation failed to promote the proliferation of DPSCs. Firstly, DPSCs stably carrying PAX9 mutant were constructed. Either an HDR or ABE8e system was delivered into the above-mentioned stable DPSCs, and then the correction efficiency using Sanger sequencing and Western blotting was determined. Meanwhile, the ABE8e presented significantly higher efficiency in correcting C175T compared with HDR. Furthermore, the corrected PAX9 presented enhanced viability and differentiation capacity for osteogenic and neurogenic lineages; the corrected PAX9 even possessed extremely enhanced transcriptional activation ability. In summary, this study has powerful implications for studies into base editors, chitosan hydrogel, and DPSCs in treating hypodontia.

10.3390/gels9060436

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The Effect of Local Application of Tea Tree Oil Adjunctive to Daily Oral Maintenance and Nonsurgical Periodontal Treatment: A Systematic Review and Meta-Analysis of Randomised Controlled Studies.

PubMed (2024)

Chenjiao Zhang Bowen Liu Jingchao Hu Li Zhao Zhao Han

To evaluate the efficacy of the adjunctive use of tea tree oil (TTO) for dental plaque control and nonsurgical periodontal treatment (NSPT).

Adjunctive treatment

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10.3290/j.ohpd.b5458585

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