Fernanda Antunes

State University of Norte Fluminense

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André Lacerda de Abreu Oliveira

State University of Norte Fluminense

Jussara Peters Scheffer

Prefeitura Municipal de Campos dos Goytacazes

Gustavo J.S. Pereira

University College London

Bryan E. Strauss

Icahn School of Medicine at Mount Sinai

Soraya S. Smaili

Universidade Federal de São Paulo

Marcelo Borges dos Santos

State University of Norte Fluminense

Fabiane Azeredo Atallah

State University of Norte Fluminense

Cláudia Bincoletto

Universidade Federal de São Paulo

Mônica Jorge Luz

State University of Norte Fluminense

Priscilla Olivieri Benck de Jesus

State University of Norte Fluminense

Cooperative Institutions

Washington Center

122

University of Washington

119

State University of Norte Fluminense

110

Universidade de São Paulo

Universidade Federal de São Paulo

Prefeitura Municipal de Campos dos Goytacazes

Universidade Federal do Rio de Janeiro

Instituto do Câncer do Estado de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade do Estado do Rio de Janeiro

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Protein Disulfide Isomerase overexpression induces mitochondrial reorganization and a differentiated VSMC phenotype: role of mitofusin-2

Free Radical Biology and Medicine (2023)

João Wosniak Rafael F.G. Rodrigues Pâmela A. Kakimoto Camille C. Caldeira da Silva Fernanda Antunes

10.1016/j.freeradbiomed.2023.10.220

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CONTROLE DE DANO EXPERIMENTAL EM LOBO HEPÁTICO MEDIAL ESQUERDO DE RATOS

Brazilian Journal of Veterinary Medicine/Revista Brasileira de Medicina Veterinária (2013)

Gabriel Barbosa Botelho de Souza Edmundo Jorge Abílio Priscilla Olivieri Benck de Jesus Alexandra de Faria do Amaral Fabiane Azeredo Atallah

ABSTRACT. Souza G.B.B., Abilio E.J., Jesus P.O.B., Amaral A.F., Atallah F.A., Silva S.J.Q., Monteiro G.A.S. & Antunes F. [Control of experimental liver injury in mice left medial lobe]. Controle de dano experimental em lobo medial esquerdo hepatico de ratos. Revista Brasileira de Medicina Veterinaria, 35(Supl. 1):30-44, 2013. Curso de Pos-Graduacao em Ciencia Animal, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Avenida Alberto Lamego, 2000, Parque California, Campos dos Goytacazes, RJ 28013602, Brasil. Email: gbbsouza@gmail.com The surgery of damage control consists of maneuver that can save lives, consisting of stop the bleeding, control the output of intestinal contents, among other, avoiding the resections and reconstructions. The challenge based on maintenance of physiological stability after injury by surgical control of the hemorrhage. Even with all the efforts, the disease evolves with a cascade of events that includes the so-called triad of death: metabolic acidosis, hypothermia, and coagulopathy. Thus, the aim of this study was to evaluate the damage control in injuries caused experimentally on hepatic lobe of Wistar rats, proposing four alternatives for damage control, confronting with histopathological data of the site of the lesion after repair. A total of 24 Wistar rats of both sexes, weight ranging between 250 and 300g were disposed in four randomized blocks, all anesthetized with a combination of ketamine and xylazine by the intraperitoneal route. After anesthesia the experimental lesion was conducted by thelaser of scalpel into hepatic lobe which is the closest to the area of the incision chosen. Later, animals were separated in groups and treatments consisting in group 1, using as a method to manual compression of the injured region (digitocrasia); Group 2, where the passage of omentum through the lesion; Group 3, with the placing of compresses folded around the injury and the Group 4, in which the fulfillment of the liver with bovine pericardium glycerin distilled preserved. After lesion cavity suture was performed and the animals evaluated daily and after seven days were re-operated for the withdrawal of the repair fragment procedure and histopathological analysis in the Laboratory of Morphology and Animal Pathology (LMPA) of Veterinary Hospital UENF. The fragment was categorized macroscopically by shape, texture, consistency and color of the surfaces. The portion removed was immediately fixed in formalin neutral-buffered 10% for a minimum period of 48 hours and after the whole process of histotecnica. The tissue regeneration was scored by descriptive statistics. During the surgical procedure the data showed that all the proposed techniques were effective in hemostasis, given that the bleeding was constrained in all the groups, especially in groups 1 and 2 that was observed an immediate hemostasis, when compared with other two groups. At the time of collection of the fragment of repair, was observed discrepancy among the groups. Macroscopic observation showed that the region repaired presented significant differences, however in groups using packing the prevalence of adherence phenomena was higher than the other groups. Besides all adherence observed, group 4 presented a further discoloration, with a whitish color, in the area of hepatic lobe involved by preserved bovine pericardium. Microscopically the differences were even greater among the groups, with the extent of the lesions ranging from absent to intense, revealing degeneration and liver cirrhosis in all segments of the study. However in group 4 the severity observed was higher and comparatively more deleterious extending to adjacent lobe which also presented dysfunction based on degeneration and congestion.

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USO DE RESINA ACRILICA NA RECONSTRUÇÃO DO PALATO DURO APÓS EXÉRESE DE CARCINOMA NASAL EM CÃO - RELATO DE CASO

DOAJ (DOAJ: Directory of Open Access Journals) (2013)

Fabiane Azeredo Atallah Oscar Fernando Tirado Estupinañ Renato Moura Ramos Daniela Fantini Vale Saulo José Quina Silva

ABSTRACT. Atallah F.A., Estupinan O.F.T., Ramos R.M.., Vale F.D., Silva S.J.Q., Costa D.R.G., Antunes F. & Oliveira A.L.A. [Use of acrylic resin in the reconstruction of the hard palate after nasal carcinoma resection in a dog - a Case report]. Uso de resina acrilica na reconstrucao do palato duro apos exerese de carcinoma nasal em cao - Relato de caso. Revista Brasileira de Medicina Veterinaria, 35(Supl. 1):112-117, 2013. Curso de Pos-Graduacao em Ciencia Animal, CCTA, Sala 207-A, Universidade Estadual Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego, 2000, Parque California, Campos dos Goytacazes, RJ 28013-602, Brasil. E-mail: fabiane-vet@hotmail.com Neoplasia of the nasal cavity are uncommon in domestic animals, although they represent only 1% of all tumors affecting the dog, tumors of the nasal cavity and paranasal sinuses comprise about 59% to 82% of all tumors of the respiratory tract canine. Consequently the position adjacent to the brain and eyes, nasal neoplasms are in a critical place, however, treatment is focused on controlling the site of injury. The preferred treatment involves radical resection of the neoplasm by rhinotomy. After surgical excision of the tumor on the hard palate, anatomical changes originate, being necessary the use of a palatal prosthesis. The objective of this study is to report the use of acrylic resin as an effective alternative for the reconstruction of bone defects created by wide resection of squamous cell carcinoma of the hard palate in a dog race doberman. At physical examination, the animal showed respiratory system changes with clinical signs of a cough, rhinorrhea, and rales on auscultation. The histopathological examination and rhinoscopy revealed the presence of squamous cell carcinoma of approximately 4 cm. respectively. Two approaches were used, the ventral rhinostomy like a palliative procedure, and chemotherapy like prophylactic treatment. The denture acrylic resin was used to reduce the palate, being effective during the time of survival.

Hard palate

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PROPOSTA DO USO DE MODELO EXPERIMENTAL DE CADÁVER DE CÃO CONSERVADO COM SOLUÇÃO DE LARSSEN MODIFICADA E FORMOL EM GEL

Confict (2015)

Chris Maciel Peçanha Ana Bárbara Freitas Rodrigues Fernanda Antunes

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The impact of flexible workspace tenancy in valuation

25th Annual European Real Estate Society Conference (2022)

Fernanda Antunes

It has been documented in academic literature and grey literature that flexible workspace providers take office space in longer leases. The rationale is straightforward as one of their key profitability components relies on benefitting from the difference between their long-term rights to a space and their short-term offerings, also known as long-short space strategy. Using a dataset of 4,687 leases in New York City extracted from Compstak over the period of 2011-2022, we analyse the overall lease term structure in different economic cycles and compare it with the lease term structure of flexible workspace providers. We also investigate the effects of flexible workspace providers as tenants on effective rents, as previous studies have demonstrated a significant difference in comparison to their peers.

Work space

Lease

Leasehold estate

Economic rent

10.15396/eres2022_32

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Remoção de fragmento balístico seguido de fixação de fratura mandibular

ARCHIVES OF HEALTH INVESTIGATION (2017)

Fernanda Antunes Ciro Borges Duailibe de Deus Hiskell Francine Fernandes e Oliveira Erik Neiva Ribeiro de Carvalho Reis Pedro Henrique Silva Gomes-Ferreira

Paciente do genero feminino, 42 anos, melanoderma, reagiu a um assalto a mao armada e foi alvejada por 5 projeteis de arma de fogo, sendo dois nos membros inferiores, dois no torax e um em face. Esta paciente deu entrada no Pronto Socorro da Santa Casa de Misericordia de Aracatuba e foi inicialmente avaliada pela clinica medica e posteriormente foi encaminhada para avaliacao com a equipe de cirurgia e traumatologia buco-maxilo-facial. Durante o exame fisico foi notado que todos os projeteis tinham ferimentos de entrada e saida, sem maiores danos as estruturas nobres das regioes acometidas, com excecao do que foi disparado em face, o qual promoveu fratura de mandibula e ficou alojado em regiao de tecidos moles de ângulo mandibular. A paciente apresentava o orificio de entrada com aspecto cauterizado (o que sugere proximidade ao agressor no momento do disparo) em regiao bucal proximo a linha naso-labial, restricao de abertura bucal, pessima higiene intrabucal, elementos dentarios 16, 17, 25, 26, 27, 35, 36, 46 e 47 fraturados, dificuldade de abertura e sintomatologia dolorosa intensa. Durante o exame de imagem foi observado em uma radiografia postero anterior de face a fratura mandibular em ângulo esquerdo e fragmento balistico em regiao de tecidos moles adjacente a fratura. A paciente foi entao internada para realizacao de cirurgia sob anestesia geral para debridamento das feridas, remocao de corpo estranho, reducao e fixacao de fratura de ângulo mandibular por acesso intrabucal. A fixacao foi realizada com uma placa de titânio do sistema 2.0 pois a fratura estava contida dentro da cinta pterigomasseterica e se apresentava estavel. A cirurgia foi realizada sem intercorrencias e a paciente foi levada a sala de recuperacao pos anestesica com respiracao espontânea. Durante o acompanhamento ambulatorial de 7, 14 e 30 dias a paciente referiu melhora no quadro algico, oclusao estavel e restricao total do edema.

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New intragastric sleeve technique reduces adipose tissue in pig experimental model: tomographic study

Scientific Reports (2020)

Mariana da Silva Ribeiro Ricardo Paiva Araújo dos Scheiba Zorron Saulo José Quina Silva Silvia Marcela Ruiz Cadena Marcelo Borges dos Santos

Abstract In order to implement a new bariatric surgery technique, we verify the efficacy of intragastric sleeve to reduce weight gain and subcutaneous adipose tissue (SAT). Animals were divided into two groups: G1 (single-port intragastric sleeve) and G2 (sham group). The stomach was surgically reduced by single-port intragastric sutures to fo a gastric sleeve. Animals were submitted to computer tomography (CT) before the surgical procedure and after 18 weeks. Images were analyzed and measurements of the thickness of SAT, depth and width of the longissimus dorsi muscle and the rib eye area were made. Body weight and CT measurements were analyzed using the GLM PROC. The correlation coefficients were calculated among weight, moments and measures. There was a significant difference in weight gain, in which G1 had an average of 42.803 ± 3.206 kg, lower than G2 (45.966 ± 4.767 kg). The mean values for SAT and muscle measurements differed significantly between groups, in which G1 achieved the lowest values. All variables had significant correlations and high magnitude. Intragastric sleeve surgery induced a significant decrease of SAT. The new intragastric sleeve technique is feasible, safe and effective, mainly in reducing fat deposition, making it an important alternative in bariatric surgical treatment.

Port (circuit theory)

Gastric banding

10.1038/s41598-020-74846-8

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COMPORTAMENTO DA FREQUÊNCIA CARDÍACA E DA TEMPERATURA CORPÓREA EM COELHOS SUBMETIDOS À PARADA CIRCULATÓRIA CARDÍACA

Ciência Animal Brasileira (2010)

Felipp Silveira Ferreira Daniela Fantini Vale Renato Moran Ramos Giseli Santos Ferreira Fábio Ferreira de Queiroz

The technique of total circulatory arrest (TCA), or inflow occlusion, consists in preventing the blood entry into the heart chambers by clamping the vena cava and the cranial and caudal vena azygos. However, changes in physiological parameters of the patient can be triggered with the application of this technique. This technique can be easily used in heart intra-cavity diseases, whose correction takes a few minutes, as in pulmonary stenosis or subaortic stenosis. Because low cost and simple implementation, it may be carried out in private clinics. In this trial, the behavior of heart rate and body temperature of rabbits submitted to two periods of five minutes of TCA, by the use of inflow occlusion technique, was evaluated. A period of blood recirculation between occlusions was performed to verify the potential benefits of this practice on the behavior of heart rate and body temperature of the animals. These parameters were assessed throughout the perioperative period. There were two deaths, both in the recirculation period due to the occurrence of ventricular fibrillation. Nevertheless, with the implementation of the period of blood recirculation, we verified that this technique can be used in intra-cardiac surgery lasting up to 10 minutes. KEYWORDS: Circulatory arrest, inflow occlusion, rabbits.

Clamp

10.5216/cab.v11i4.8866

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Pancreatectomia parcial: uma opção de tratamento realizada emum cão com insulinoma maligno - relato de caso

MEDVEP. Revista Científica de Medicina Veterinária. Pequenos Animais e Animais de Estimação (2012)

Fabiane Azeredo Atallah LARISSA ISABELLE VISNHESKI LOPES Heloísa Justen Moreira de Souza Ricardo Siqueira da Silva Fernanda Antunes

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New Technique for Intrathoracic Implantation of Extraluminal Spiral Prostheses in the Trachea

ACTA SCIENTIAE VETERINARIAE (2021)

Hércules Lúcio Gomes Rodiney Pinheiro Denevitz Isabella Cristina Morales Scarlath Ohana Penna dos Santos Haroldo José Siqueira da Igreja Júnior

Background: Extraluminal surgical procedures for intrathoracic tracheal collapse in dogs are not routinely performed. The patients are normally treated with different drugs or by intraluminal stents. However, in more severe cases, drug treatment does not always have good outcomes, and intraluminal prostheses can be correlated to several postoperative problems. In order to obtain better results, we aimed to develop a surgical technique for implantation of a new extraluminal helical prosthesis in the thoracic segment of the trachea through cervical access, associated with pneumatic mediastinoscopy for certification of the technique and minimization of possible complications.Materials, Methods & Results: Seven canine corpses (CCs) from non-traumatic death, weighing between 2 and 7 kg, were used. A ventral cervical approach to the trachea was associated with blunt mediastinal dissection. Trans cervical pneumatic mediastinoscopy was used for evaluation of the dissection and location of the implant. These were compared with the necropsy findings by the exact Wilcoxon two-sample test, with P < 0.05. The results of necropsy and mediastinoscopy did not present significant differences at P < 0.05. During the examinations, the presence of some mediastinal visceral lesions caused by the prosthesis, the integrity of the mediastinum and possible lesions to RLN and blood vessels (BV) were analyzed. We also investigated the location of the distal part of the prosthesis in the thoracic segment of the trachea and its dissection. To evaluate the technique, statistical comparison was made between mediastinoscopy and necropsy findings. The data were compared by the Wilcoxon test at 5% probability. The tracheas of all CCs were efficiently dissected, but in some cases problems that can happen during the procedure were noticed. This was checked by mediastinoscopy and confirmed by necropsy. The median of the scores was 1 (good dissection and visualization), with variance of zero for mediastinoscopy and 0.14 for necropsy. In the mediastinoscopy of one CC, the prosthesis crossed the tracheal bifurcation, involving the posterior vessels of this region, which was confirmed by necropsy. However, the dissection showed no vascular lesions. The integrity of the mediastinum was assessed only by mediastinoscopy. There was no impairment caused by any of the procedures performed. This resulted in a median score of 1 (integrity) with zero variance. When the positioning of the prosthesis was evaluated in relation to the tracheal bifurcation, identical values were obtained by both methods. The median score was 1, with variance of 0.62. No statistical differences were found between the two evaluation methods for the analyzed variables. This demonstrates the strong potential of the proposed evaluation techniques.Discussion: Our results show that the execution of the technique is possible, but some complications may occur. Mediastinoscopy as an evaluation procedure can pose some complications, these considerations are important, but by using technique proposed in this study, these factors are minimized due to the ease of technical implantation of the extraluminal tracheal stent, without the need for several instruments competing in the inflated mediastinal space. We concluded that the technique is viable and a safe method with minimal invasion for investigation and treatment of mediastinal diseases, presenting low impairment of the paratracheal structures, and that mediastinoscopy can be used as a transoperative evaluation method to minimize complications.

10.22456/1679-9216.110187

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