e13079 Background: Choriocarcinoma (CCA) is a rare tumor. In men, the main site is testis. Pure CCA composes < 0.3% of testicular germ cell tumors. Other sites may represent metastatic disease (dz) or a non-testicular primary CCA. Surgery (S) is the preferred treatment as diagnosis prior to resection is difficult. We analyzed SEER data to determine demographic/clinical characteristics of male CCA patients (pts) and assess survival outcomes. Methods: Male pts with a confirmed diagnosis of CCA as their only primary tumor were included. Pts were grouped into cohorts by dz site (testis, other primary sites, all). S was defined as any type of surgery or no surgery. Stage was defined as local/regional or distant. Dz type was defined as pure or mixed. Overall survival (OS) and disease-specific survival (DSS) were analyzed with Cox proportional hazards (PH) models and Kaplan-Meier methods (5-yr landmark rates reported). Results: 1221 men were identified from 1988-2013. Median age = 28 (range 0-84). Other characteristics included: White (86.9%), mixed CCA (64.9%), local/regional (45.4%), S (78.7%) and testis (83.0%). For other primary site pts (17.0%), lung/mediastinum was most common (36.7%). Stage and S significantly impacted OS and DSS, regardless of dz site. For testis pts, OS (95% vs 56%; p < .001) and DSS (96% vs 61%; p < .001) were significantly better for pts with local/regional dz, as were OS (68% vs 27%; p = 0.032) and DSS (68% vs 29%; p = 0.042) for other primary site pts. Testis pts with S had significantly improved OS (83% vs 34%; p < .001) and DSS (85% vs 40%; p < .001), as did other primary site pts with S (OS: 54% vs. 23%; p = 0.004 and DSS: 62% vs. 34%; p = 0.002). OS for all pts was analyzed with a multivariable Cox PH model, including age, marital status, dz site and type, stage, and S. Testis pts had a reduced risk of death compared to other primary site pts (HR 0.66; 95% CI 0.47-0.92). Pure CCA pts had a 61% increased risk of death compared to mixed CCA pts (HR 1.61; 95% CI 1.24-2.08). S pts had a 48% reduced risk of death compared to pts without S (HR 0.52; 95% CI 0.40-0.67). Conclusions: Pure CCA and non-testicular primary pts have poorer outcomes. S is an important component to survival in men with CCA. This is the first descriptive analysis of male CCA utilizing SEER.
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