Byung‐Yong Kim

Chong Kun Dang Bio (South Korea)

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Research Trends

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Co-Authors

Hang-Yeon Weon

Rural Development Administration

104

Moo‐Yeol Baik

Kyung Hee University

Soon-Wo Kwon

Rural Development Administration

Seung-Joo Go

National Institute of Agricultural Science and Technology

Erko Stackebrandt

Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures

Jae-Hyung Ahn

Rural Development Administration

Jaekyeong Song

Rural Development Administration

Se Won Kang

Korea Research Institute of Bioscience and Biotechnology

Byeong Seob Oh

Korea Research Institute of Bioscience and Biotechnology

Keun Chul Lee

Korea Research Institute of Bioscience and Biotechnology

Cooperative Institutions

Seoul National University

173

Kyung Hee University

142

Yonsei University

118

Rural Development Administration

103

Korea University

National Academy of Agricultural Science

Korea Research Institute of Bioscience and Biotechnology

National Institute of Agricultural Science and Technology

Sungkyunkwan University

Pusan National University

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Microbial Diversity and Community Analysis in Lettuce or Cucumber Cultivated Greenhouse Soil in Korea

Korean Journal of Soil Science and Fertilizer (2011)

Byung‐Yong Kim Hang-Yeon Weon Incheol Park Sang Yeob Lee Wan-Gyu Kim

시설재배지의 토양미생물 분포 특성을 밝히고 토양의 건전성을 평가하고자, 전국 주요 시설재배 8개 주산단지에서 각각 5포장을 선정하여 토양화학성, 미생물분포 및 생화학적 특성을 조사하였다. 토양화학성은 가용성인산, 칼륨, 칼슘의 함량이 적정범위보다 크게 상회하여 상당량의 염류 집적을 확인하였다. 토양미생물의 배양적 방법을 통해 조사한 시설재배지의 주요 우점 박테리아는 Bacillus 속, Microbacterium 속, Arthrobacter 속, Lysobacter 속 등이었으며, 형광성 Pseudomonas 속의 밀도는 상추와 오이 재배지에서 각각 $0.018-7.3{\times}10^4\;cfu\;g^{-1}$, $0.0013-9.6{\times}10^4\;cfu\;g^{-1}$으로 시료에 따라 큰 변이를 보였다. 비배양학적 방법을 통한 토양미생물 분포 조사를 위해 수행한 인지질지방산 (PLFA)의 주성분 분석 결과, 작물 및 지역별 군집구조의 큰 차이는 없었다. 따라서 토양화학성 및 미생물군집구조 측면에서 시설재배지 조사지역의 토양은 대체로 건전한 것으로 판단된다. The soil chemical properties, microbial community structures and biochemical properties of lettuce or cucumber-cultivated greenhouse soil samples were analyzed to assess soil health and characterize microbial distribution in 8 locations in Korea. Although most of chemical properties were within the soil management guidelines, the available phosphate, and the contents of exchangeable potassium and calcium were higher than those of recommended levels. In the culture-dependent analysis, 841 bacterial strains were isolated from the greenhouse soils and were identified at the genus level by 16S rRNA gene sequences analysis. The dominant bacterial genera were Bacillus (35.7%), Microbacterium (9.3%), Arthrobacter (5.7%) and Lysobacter (5.1%). The abundance of pseudomonads was highly variable depending on the soil samples. In the culture-independent analysis, soil microbial community was investigated by using phospholipid fatty acid (PLFA) method. Principal component analysis (PCA) showed that a specific grouping for microbial community structure in the greenhouse soils was not observed based on cultivated crops and investigated sites. The results revealed that the greenhouses soils examined are relatively sound managed in terms of soil chemical contents and microbial properties.

Arthrobacter

Microbacterium

Soil microbiology

Soil test

10.7745/kjssf.2011.44.6.1169

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Citations (10)

Rhizolutin directly dissociates Aβ and tau aggregates and reduces apoptosis/inflammation related to Alzheimer’s disease

Alzheimer s & Dementia (2021)

Jisu Shin Y.S. Kwon Kwangho Nam Joon Soo An Seung‐Hoon Yang

Abstract Background Alzheimer’s disease (AD) is characterized by the aggregation of amyloid‐β (Aβ) and tau, leading to neuronal cell death, neuroinflammation, and brain atrophy. As Aβ and tau aggregates are observed in the brain decades before the onset of cognitive symptoms, clearance of these aggregates has been widely accepted for AD treatments. Method Through the unbiased screening against the natural product libraries, rhizolutin was selected and its regulatory effects on Aβ and tau aggregation were validated by thioflavin T assays. Clearance of Aβ plaques was observed in APP/PS1 double transgenic AD model mice and subsequent analyses regarding apoptosis and inflammation were conducted using neuronal and glial cell lines. Result Rhizolutin‐treated AD model mice significantly decreased hippocampal Aβ plaques. Additionally, rhizolutin effectively inhibited the aggregation of Aβ and tau in vitro , more importantly, dissociated both aggregates, thereby reducing Aβ‐induced apoptosis and inflammation in neuronal and glial cells. Conclusion Our findings reveal that a unique chemical rhizolutin regulates both Aβ and tau at the same time by therapeutic and preventive approaches, representing its novel structure is attractive for AD drug discovery.

Tau Pathology

Amyloid (mycology)

10.1002/alz.049661

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Application of Amplicon Pyrosequencing in Soil Microbial Ecology

Korean Journal of Soil Science and Fertilizer (2012)

Jae-Hyung Ahn Byung‐Yong Kim Dae‐Hoon Kim Jaekyeong Song Hang-Yeon Weon

Soil microbial communities are immensely diverse and complex with respect to species richness and community size. These communities play essential roles in agricultural soil because they are responsible for most of the nutrient cycles in the soil and influence the plant diversity and productivity. However, the majority of these microbes remain uncharacterized because of poor culturability. Next-generation sequencing techniques have revolutionized many areas of biology by providing cheaper and faster alternatives to Sanger sequencing. Among them, amplicon pyrosequencing is a powerful tool developed by 454 Life Sciences for assessing the diversity of complex microbial communities by sequencing PCR products or amplicons. This review summarizes the current opinions in amplicon sequencing of soil microbial communities, and provides practical guidance and advice on sequence quality control, aligning, clustering, OTU- and taxon-based analysis. The last section of this article includes a few representative studies conducted using amplicon pyrosequencing.

Pyrosequencing

Amplicon sequencing

Amplicon

Sanger sequencing

10.7745/kjssf.2012.45.6.1073

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Niabella terrae sp. nov. isolated from greenhouse soil

The Journal of Microbiology (2013)

Jae-Hyung Ahn Eun-Hye Jo Byung‐Yong Kim Jaekyeong Song Soon-Wo Kwon

Strain (injury)

Bacterial strain

10.1007/s12275-013-3507-9

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Periodic change in coastal microbial community structure associated with submarine groundwater discharge and tidal fluctuation

Limnology and Oceanography (2016)

Eunhee Lee Doyun Shin Sung Pil Hyun Kyung‐Seok Ko Hee Sun Moon

Abstract Coastal areas where submarine groundwater discharge (SGD) occurs are active mixing zones with characteristic biogeochemical and ecological functions. In this study, we investigated the microbial community associated with the changes in groundwater discharge flux at a coastal beach site on Jeju Island, South Korea. We performed water chemistry analyses, 16S rRNA gene‐based pyrosequencing, and microbial community statistical analyses on coastal water samples systematically collected as functions of tidal stage and distance from the groundwater discharge point. We also carried out groundwater level monitoring and numerical simulation of the coastal aquifer to reproduce tidally induced variations in the SGD rates of the study site. Pyrosequencing and statistical analyses revealed a periodic shift in the microbial communities in the coastal waters as functions of tidal stage and SGD rates. Interestingly, the community structures in the samples collected at flood and ebb tide were markedly different, despite the similarities in their water chemistry. Groundwater simulation and canonical correspondence analyses suggest that groundwater discharging at higher velocities at ebb tide can detach and transport subsurface bacteria from the aquifer to the coastal water body, resulting in an increase in facultative anaerobes in the ebb tide samples. In addition, release of the sand‐attached bacteria as a result of particle resuspension and flushing of shallow subsurface bacteria in the intertidal zone could contribute to shaping the relative abundance of the coastal microbial community. We conclude that SGD rate is an important factor influencing the dynamics of the bacterial community structure at the coastal zone of the study site.

Submarine groundwater discharge

Biogeochemical Cycle

Groundwater discharge

10.1002/lno.10433

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Citations (44)

Enhancement of Minor Ginsenosides Contents and Antioxidant Capacity of American and Canadian Ginsengs (Panax quinquefolius) by Puffing

Antioxidants (2019)

Min‐Soo Kim Sung-Joon Jeon So Jung Youn Hyungjae Lee Young‐Joon Park

The effects of puffing on ginsenosides content and antioxidant activities of American and Canadian ginsengs, Panax quinquefolius, were investigated. American and Canadian ginsengs puffed at different pressures were extracted using 70% ethanol. Puffing formed a porous structure, inducing the efficient elution of internal compounds that resulted in significant increases in extraction yields and crude saponin content. The content of minor ginsenosides (Rg2, Rg3, compound K) increased with increasing puffing pressure, whereas that of major ginsenosides (Rg1, Re, Rf, Rb1, Rc, Rd) decreased, possibly due to their deglycosylation and pyrolysis. Furthermore, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging activity, total phenolic content, total flavonoid content, amount of Maillard reaction products, and acidic polysaccharides content increased with increasing puffing pressure, but 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity did not. There was no substantial difference in the results between puffed American and Canadian ginsengs. Consequently, these results suggest that puffing can be a promising novel technology for processing P. quinquefolius to achieve higher levels of minor ginsenosides and obtain value-added products.

ABTS

10.3390/antiox8110527

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Citations (18)

Physicochemical Properties of Mucin Extracted from <i>Misgurnus mizolepis</i> Epidermal Mucus

Food Engineering Progress (2020)

Sooyoun Kim Moo‐Yeol Baik Byung‐Yong Kim

The purpose of this study was to investigate the extraction yield and physicochemical characteristics of mucin from the epidermal mucus of Misgurnus mizolepis. Ninety percent ethanol produced the highest yield of mucin. At higher concentrations, mucin had more elastic properties, as revealed by dynamic viscoelasticity measurements. Differential scanning calorimetry (DSC) demonstrated that mucin is a thermostable glycoprotein. Denaturation enthalpy increased as mucin concentration increased. Mucin inhibited the growth of both Escherichia coli and Bacillus cereus, but had better antimicrobial activity in the former. Mucin also exhibited antioxidant activity, equivalent to 66.64% of that of L-cysteine. Mucin inhibited elastase activity and MMP-1 & MMP-2 expression activity, and induced hyaluronic acid expression. It is indicating that mucin is effective in moisturizing and anti-aging the skin. Thus, mucin from the epidermal mucus of Misgurnus mizolepis could have great potential as a non-food material in various industries.

10.13050/foodengprog.2020.24.3.178

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Isolation and characterization of starches from chestnuts cultivated in three regions of Korea

Starch - Stärke (2015)

Jae-Wook Lee Hyun‐Wook Choi Dong‐Ho Seo Jong-Dae Park Jun-Seok Kum

Chestnut starches were isolated from chestnuts cultivated in three different regions of Korea (Gongju-si (GJ), Gwangyang-si (GY), and Hadong-gun (HD)), and their physicochemical properties were investigated to assess further potential commercial uses of chestnuts. GJ and HD had higher protein and fat content than GY. GJ had the highest amylose content (20.37%). Chestnut starch granules were shaped as rounded triangles or irregular ovals, 2–10 µm in size, with B-type X-ray diffraction patterns. HD showed the highest solubility and swelling power at 90°C. DSC analysis revealed that the thermal properties of the three starches were not significantly different (p < 0.05). In RVA, chestnut starches displayed relatively lower pasting temperatures and higher peak viscosity and breakdown values than corn starch. It is very interesting to note that chestnut starches formed gels at relatively low concentrations (5%), and their gels had much higher freeze-thaw stability than corn starch.

Corn starch

10.1002/star.201500034

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Citations (17)

Draft genome sequence of Blautia sp. KGMB01111 isolated from a healthy Korean human faeces

The Microbiological Society of Korea (2020)

Jam Eon Park Jisun Kim Seung Hyeon Choi Kook Il Han Se Won Kang

Sequence (biology)

Human feces

10.7845/kjm.2020.9159

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Citations (3)