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Marianne A. B. van der Sande

University Medical Center Utrecht

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Christian J. P. A. Hoebe

Maastricht University

Maarten F. Schim van der Loeff

University of Amsterdam

Hilton Whittle

London School of Hygiene & Tropical Medicine

Fiona van der Klis

National Institute for Public Health and the Environment

Hannelore M Götz

GGD Rotterdam-Rijnmond

Jan van Bergen

Aidsfonds

Wim van der Hoek

National Institute for Public Health and the Environment

Henry J.C. de Vries

Amsterdam Institute for Addiction Research

Birgit van Benthem

National Institute for Public Health and the Environment

Adam Meijer

National Institute for Public Health and the Environment

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National Institute for Public Health and the Environment

MRC Unit the Gambia

University of Amsterdam

University Medical Center Utrecht

Utrecht University

Amsterdam University Medical Centers

Maastricht University

Academic Medical Center

Instituut voor Tropische Geneeskunde

Medical Research Council

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Increasing sexually transmitted infection rates in young men having sex with men in the Netherlands, 2006–2012

Emerging Themes in Epidemiology (2014)

Femke D. H. Koedijk Birgit HB van Benthem Eliane MDC Vrolings Wim Zuilhof Marianne A. B. van der Sande

Men having sex with men (MSM) remain the largest high-risk group involved in on-going transmission of sexually transmitted infections (STI), including HIV, in the Netherlands. As risk behaviour may change with age, it is important to explore potential heterogeneity in risks by age. To improve our understanding of this epidemic, we analysed the prevalence of and risk factors for selected STI in MSM attending STI clinics in the Netherlands by age group.Analysis of data from the national STI surveillance system for the period 2006-2012. Selected STI were chlamydia, gonorrhoea, infectious syphilis and/or a new HIV infection. Logistic regression was used to identify factors associated with these selected STI and with overall STI positivity. Analyses were done separately for MSM aged younger than 25 years and MSM aged 25 years and older.In young MSM a significant increase in positivity rate was seen over time (p < 0.01), mainly driven by increasing gonorrhoea diagnoses, while in MSM aged 25 and older a significant decrease was observed (p < 0.01). In multivariate analyses for young MSM, those who were involved in commercial sex were at higher risk (OR: 1.5, 95% CI: 1.2-1.9). For MSM aged 25 years and older this was not the case. Having a previous negative HIV test was protective among older MSM compared to those not tested for HIV before (OR: 0.8, 95% CI: 0.8-0.8), but not among younger MSM.MSM visiting STI clinics remain a high-risk group for STI infections and transmission, but are not a homogenous group. While in MSM aged older than 25 years, STI positivity rate is decreasing, positivity rate in young MSM increased over time. Therefore specific attention needs to be paid towards targeted counselling and reaching particular MSM sub-groups, taken into account different behavioural profiles.

10.1186/1742-7622-11-12

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Supplementary Table S1 from HPV Seroconversion Following Anal and Penile HPV Infection in HIV-Negative and HIV-Infected MSM

Sofie H. Mooij Olivia Landén Fiona van der Klis Marianne A. B. van der Sande Hester E. de Melker

<p>Supplementary Table S1. Associations between anal and penile HPV infection and type-specific seroconversion, using the stricter definition of seroconversion.</p>

Seroconversion

Anal intercourse

Anal sex

10.1158/1055-9965.22435884.v1

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Where to go to in chlamydia control? From infection control towards infectious disease control

Sexually Transmitted Infections (2021)

Jan van Bergen Bernice M Hoenderboom Silke David F. Deug Janneke C. M. Heijne

Objectives The clinical and public health relevance of widespread case finding by testing for asymptomatic chlamydia infections is under debate. We wanted to explore future directions for chlamydia control and generate insights that might guide for evidence-based strategies. In particular, we wanted to know the extent to which we should pursue testing for asymptomatic infections at both genital and extragenital sites. Methods We synthesised findings from published literature and from discussions among national and international chlamydia experts during an invitational workshop. We described changing perceptions in chlamydia control to inform the development of recommendations for future avenues for chlamydia control in the Netherlands. Results Despite implementing a range of interventions to control chlamydia, there is no practice-based evidence that population prevalence can be reduced by screening programmes or widespread opportunistic testing. There is limited evidence about the beneficial effect of testing on pelvic inflammatory disease prevention. The risk of tubal factor infertility resulting from chlamydia infection is low and evidence on the preventable fraction remains uncertain. Overdiagnosis and overtreatment with antibiotics for self-limiting and non-viable infections have contributed to antimicrobial resistance in other pathogens and may affect oral, anal and genital microbiota. These changing insights could affect the outcome of previous cost–effectiveness analysis. Conclusion The balance between benefits and harms of widespread testing to detect asymptomatic chlamydia infections is changing. The opinion of our expert group deviates from the existing paradigm of ‘test and treat’ and suggests that future strategies should reduce, rather than expand, the role of widespread testing for asymptomatic chlamydia infections.

Tubal factor infertility

Pelvic inflammatory disease

Partner notification

10.1136/sextrans-2021-054992

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Cardiovascular disease in the Gambia

Marianne A. B. van der Sande

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Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis

The Lancet Infectious Diseases (2019)

Chunqing Lin J Sláma Paula González Marc T. Goodman Ningshao Xia

10.1016/s1473-3099(19)30164-1

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Nieuwe influenza A (H1N1): geadviseerde indicatie en voorschrijfgedrag van antivirale middelen

C C Kees van den Wijngaard Jim van Steenbergen Marianne A. B. van der Sande Marion Koopmans

C.C. (Kees) van den Wijngaard, Jim E. van Steenbergen, Marianne A.B. van der Sande en Marion P.G. Koopmans Nederland heeft nog maar weinig zieken als gevolg van de nieuwe influenza A (H1N1) (ook bekend als ‘Mexicaanse griep’). Op 17 juli 2009 waren er 179 bevestigde geval- len gemeld. Bij 63 daarvan had de besmetting in Neder-land plaatsgevonden (www.rivm.nl/cib/themas/nieuwe- influenza/#index_1). Een van de voorzorgsmaatregelen van de Nederlandse overheid is de aanleg van een natio-nale voorraad antivirale neuraminidaseremmers van circa 5 miljoen kuren, bestaande uit 4,5 miljoen eenheden oseltamivir en 0,5 miljoen eenheden zanamivir. Deze virusremmers bekorten de ziekteduur met een dag en verminderen mogelijk de kans op complicaties. Bovendien wordt de kans op verspreiding van het virus kleiner.

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NHG-Standaard Influenzapandemie

Bohn Stafleu van Loghum eBooks (2009)

A G Van Essen H F Berg H J Bueving J R van der Laan C P Van Lidth de Jeude

10.1007/978-90-313-6614-9_85

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2001 Anorectal function after watch and wait-policy in rectal cancer patients

European Journal of Cancer (2015)

B. Hupkens Doenja M. J. Lambregts Marianne A. B. van der Sande Maaike Berbée M. Martens

10.1016/s0959-8049(16)30927-3

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Changes in chlamydia control activities in Europe between 2007 and 2012: a cross-national survey

European Journal of Public Health (2015)

Ingrid V. van den Broek O Sfetcu Marianne A. B. van der Sande Berit Andersen Björn Herrmann

Background: In 2012, the levels of chlamydia control activities including primary prevention, effective case management with partner management and surveillance were assessed in 2012 across countries in the European Union and European Economic Area (EU/EEA), on initiative of the European Centre for Disease Control (ECDC) survey, and the findings were compared with those from a similar survey in 2007. Methods: Experts in the 30 EU/EEA countries were invited to respond to an online questionnaire; 28 countries responded, of which 25 participated in both the 2007 and 2012 surveys. Analyses focused on 13 indicators of chlamydia prevention and control activities; countries were assigned to one of five categories of chlamydia control. Results: In 2012, more countries than in 2007 reported availability of national chlamydia case management guidelines (80% vs . 68%), opportunistic chlamydia testing (68% vs . 44%) and consistent use of nucleic acid amplification tests (64% vs . 36%). The number of countries reporting having a national sexually transmitted infection control strategy or a surveillance system for chlamydia did not change notably. In 2012, most countries (18/25, 72%) had implemented primary prevention activities and case management guidelines addressing partner management, compared with 44% (11/25) of countries in 2007. Conclusion: Overall, chlamydia control activities in EU/EEA countries strengthened between 2007 and 2012. Several countries still need to develop essential chlamydia control activities, whereas others may strengthen implementation and monitoring of existing activities.

Eu countries

10.1093/eurpub/ckv196

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50. Quality of life in rectal cancer patients: Watch-and-wait policy versus standard treatment – A matched controlled study

European Journal of Surgical Oncology (2016)

B. Hupkens Marianne A. B. van der Sande Monique Maas M. Milou Doenja M. J. Lambregts

10.1016/j.ejso.2016.06.056

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