Franco A. Bignone

Alleanza Contro il Cancro

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Co-Authors

Renata Finollo

University of Genoa

Marco Propato

Centre d'Études Scientifiques et Techniques d'Aquitaine

Carlo Avignolo

University of Genoa

Antonietta Martelli

University of Genoa

Silla Cai

National Institute of Dental and Craniofacial Research

Giovanni Brambilla

Mohammed Bin Rashid University of Medicine and Health Sciences

Pia Carlo

University of Genoa

Anna Ledda

University of Genoa

Giuseppe Pizzorno

Yale University

Riccarda Roner

Alleanza Contro il Cancro

Cooperative Institutions

University of Genoa

Istituti di Ricovero e Cura a Carattere Scientifico

Alleanza Contro il Cancro

University of Milan

University of Florence

Temple University

Istituto Giannina Gaslini

University of Cagliari

Università Cattolica del Sacro Cuore

Sapienza University of Rome

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Structural Complexity of Early Embryos: A Study on the Nematode Caenorhabditis elegans.

Journal of Biological Physics (2001)

Franco A. Bignone

Caenorhabditis

Developmental Biology

10.1023/a:1013178514397

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Citations (16)

Doxorubicin cytotoxicity to P388 lymphocytic leukemia as determined by alkaline elution and established assays.

PubMed (1986)

Patrizia Russo Favoni Re Daniela Zarcone Loredana Miglietta Marco Peluso

Very large variations exist in the response of individual tumors to antineoplastic agents, even when the tumors are apparently very similar from the point of view of stage and histological classification. It has been recognized for a long time that methods capable of revealing the specific chemosensitivity of individual tumors could be useful for an individual optimization of a chemotherapeutic protocol. The Tumor Colony Forming Assay (TCFA) and the Biochemical Antimetabolic Assay (BAA) have been proposed for this purpose. Their main limitation is a consequence of the fact that the capability of in vitro growth is required from cells of a tumor grown in vivo. This is often lacking or very poor in the first in vitro passages. In this work we have investigated the possibility of using a sensitive method for evaluating DNA damage, the Alkaline Elution technique (AE). Cells treated in vivo can be easily tested directly for DNA damage. No cell proliferation in vitro is required. It is not required that the measured effect is the specific cause of cell death. A P388 Doxorubicin sensitive line and a resistant subline were tested. Correct correlations between DNA damage and chemosensitivity were obtained working both in vivo and in vitro. This test could be useful for assessing the chemosensitivity in vivo of alkylating and intercalating agents.

Chemosensitivity assay

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Citations (4)

Cytogenetic findings in 4952 prenatal diagnoses. An Italian collaborative study

Human Genetics (1982)

Giuseppe Simoni M. Fraccaro A Arslanian Matthew Bacchetta C Baccichetti

Amniocentesis

Advanced maternal age

10.1007/bf00281266

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Citations (15)

G-Bands without pretreatment of slides, in chemically defined conditions

Human Genetics (1983)

Franco A. Bignone Claudio Panarello Giorgio Gimelli

Giemsa stain

G banding

10.1007/bf00285400

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Citations (4)

Biotinylation of double stranded DNA after transamination

Biochemical and Biophysical Research Communications (1990)

Carlo Avignolo Piera Valente Silla Cai Riccarda Roner Anna Fulle

Transamination

Cytosine

Cytidine

Bisulfite

10.1016/0006-291x(90)91266-u

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Citations (6)

Viscoelastic properties of native DNA from intact nuclei of mammalian cells

Journal of Molecular Biology (1982)

Claudio Nicolini Pia Carlo Antonietta Martelli Renata Finollo Franco A. Bignone

10.1016/0022-2836(82)90284-4

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Citations (28)

Complex evolution in genetic networks

EPL (Europhysics Letters) (1997)

Franco A. Bignone Roberto Livi Marco Propato

A simple model of diffusively coupled genetic networks on a 1d lattice is considered as a case study for characterizing complex unpredictable dynamics in Lyapunov-stable spatially extended systems. This dynamical regime, corresponding to transient evolution lasting over times that grow exponentially with the system size, is shown to be associated to the existence of a multifractal attractor in the thermodynamic limit. Space-time averages of proper observables exhibit robust statistical properties for finite, sufficiently large samples.

Multifractal system

Thermodynamic limit

Lattice (music)

Time evolution

10.1209/epl/i1997-00494-8

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Citations (3)

The relative intranuclear positions of barr bodies in XXX non-transformed human fibroblasts

Experimental Cell Research (1986)

Andrew S. Belmont Franco A. Bignone Paul O. P. Ts’o

Interphase

Human cell