John F. Harper

Texas Health Dallas

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Influence of Smoking on the Location of Acute Myocardial Infarctions

ISRN Cardiology (2011)

Rahel Alemu Eileen E. Fuller John F. Harper Mark Feldman

Objective. To determine whether there is an association between smoking and the location of acute myocardial infarctions. Methods. Using a cohort from our hospital and published cohorts from Ireland, Uruguay, and Israel, we calculated odds of having an inferior wall as opposed to an anterior wall acute myocardial infarction among smokers and nonsmokers. Results. In our cohort, there was a higher proportion of smokers than nonsmokers in patients with inferior acute myocardial infarctions than in patients with anterior infarctions. This difference was also present in each of the other cohorts. Odds ratios for an inferior versus an anterior acute myocardial infarction among smokers ranged from 1.15 to 2.00 (median odds ratio, 1.32). When the cohorts were combined (n = 3, 160), the pooled odds ratio for an inferior as opposed to an anterior acute myocardial infarction among smokers was 1.38 (95% confidence interval, 1.20 to 1.58) (P < .002). Conclusions. Cigarette smoking increases the risk of inferior wall acute myocardial infarction more than the risk of anterior wall infarction. Smoking thus appears to adversely affect the right coronary arterial circulation to a greater extent than the left coronary arterial circulation by a mechanism not yet understood.

Anterior wall

Odds

10.5402/2011/174358

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Citations (18)

Further delineation of the ear, patella, short stature syndrome (Meier-Gorlin syndrome)

Clinical Dysmorphology (1994)

Richard G. Boles Ahmad S. Teebi Deena Schwartz John F. Harper

Two daughters of phenotypically normal parents are described with severe proportional dwarfism with microcephaly, peculiar craniofacial anomalies, microtia, absent patellae, joint hyperextensibility, and other anomalies. Intrafamilial variability is minimal. This combination of anomalies has many similarities to the six cases previously described with the Ear, Patellae, Short stature syndrome (Meier-Gorlin syndrome), which is distinguished by the triad of microtia, absent patellae and growth retardation. Autosomal recessive inheritance is strongly suggested by the presence of two pairs of affected siblings and the equal sex ratio.

Deletion syndrome

10.1097/00019605-199407000-00004

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Citations (46)

Inherited skin disorders : the genodermatoses

Butterworth-Heinemann eBooks (1996)

John F. Harper Marcus Pembrey

Section 1: Introduction - Clinical perspectives in medical genetics Naturally occurring genetic skin diseases in animals The skin before birth Section 2: Specific Disease Groups - Epidermolysis bullosa The Ichthyoses Erythrokeratodermas, follicular keratoses, palmoplantar keratodermas and porokeratoses Metabolic disorders Ectodermal dysplasias Neurocutaneous syndromes Disorders of Collagen and Elastin Vascular disorders Photosensitivity diseases Pigmentary disorders Premature ageing syndromes The hair and scalp Hereditary and congenital nail disorders Disorders of DNA and chromosomal instability Primary immunodeficiency diseases Genetic diseases which predispose to malignancy Section 3: General Principles of Diagnosis and Management - Genetic counselling Prenatal diagnosis by fetal skin biopsy Pre-implantation diagnosis What future is there in gene therapy? Appendix I: The human gene map for dermatology Appendix II: Index of syndromes Appendix III: Index of differential diagnosis.

Palmoplantar keratoderma

Skin biopsy

Hereditary Diseases

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Citations (0)

Relation of Nausea and Vomiting in Acute Myocardial Infarction to Location of the Infarct

The American Journal of Cardiology (2009)

Eileen E. Fuller Rahel Alemu John F. Harper Mark Feldman

Myocardial infarction complications

10.1016/j.amjcard.2009.07.038

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Citations (19)

858 ORAL TREATMENT OF INHERITED VITAMIN B12-RESPONSIVE METHYLMALONIC ACIDEMIA (MMA)

Pediatric Research (1985)

Flemming Skovby John F. Harper Maurice J. Mahoney

Methylmalonic acidemia

Mutase

10.1203/00006450-198504000-00888

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Citations (1)

Intragenic deletions in 21 Duchenne muscular dystrophy (DMD)/Becker muscular dystrophy (BMD) families studied with the dystrophin cDNA: location of breakpoints on HindIII and BglII exon-containing fragment maps, meiotic and mitotic origin of the mutations.

PubMed (1988)

Basil T. Darras Peggy Blattner John F. Harper Alfred J. Spiro Svenja Alter

BglII

Breakpoint

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Citations (154)

Effects of systole-specific pericardial pressure increases on coronary flow

Journal of Applied Physiology (1991)

Constantine A. Hassapoyannes John F. Harper Logan Stuck Carlton A. Hornung Francis L. Abel

It has been postulated that intrathoracic pressure increases may impair cardiac function by decreasing coronary flow. To determine whether altered coronary flow causes or results from change in cardiac function, we used 14 anesthetized dogs in propranolol-induced heart failure following atrioventricular node ablation. After thoracoabdominal binding, the animals were paced and ventilated at the same frequency, and inspiration was synchronized with cardiac systole, resulting in systole-specific pericardial pressure increases (SSPPI). At SSPPI magnitudes of 15 and 30 mmHg, left atrial transmural pressure decreased and cardiac output increased, whereas decreases in left ventricular end-systolic transmural pressure and myocardial O2 consumption were directly related. Concurrent decreases in coronary sinus flow (CSF) and coronary arteriovenous O2 gradient with SSPPI 15 mmHg indicate autoregulation. However, the arteriovenous O2 gradient remained unaltered with SSPPI 30 mmHg, despite further decrease in CSF. Because the absolute diastolic aortic pressure decreased, a limit may exist for increasing SSPPI above which CSF may be directly affected.

Systole

Cardiac cycle

Aortic pressure

Ventricular pressure

10.1152/jappl.1991.71.1.104

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Citations (2)

Factors Associated with an Increase in 30-Day Readmission Rate for Congestive Heart Failure

Journal of Cardiac Failure (2013)

Michael Berk Gina Sundstrom Debby A. Rush John F. Harper Kandice Miller

10.1016/j.cardfail.2013.06.268

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