Jianxiang Huang

Shanghai Jiao Tong University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Ruhong Zhou

Zhejiang University

Fuhua Wang

Guangdong Academy of Agricultural Sciences

Shouwei Jian

Wuhan University of Technology

Baodong Li

Chalmers University of Technology

Youqing Shen

Zhejiang University

Farong Huang

East China University of Science and Technology

Zhuxian Zhou

Zhejiang University

Lei Du

Xuzhou Medical College

Kai Wan

Guangdong Academy of Agricultural Sciences

Ying Su

Hubei University of Technology

Cooperative Institutions

Zhejiang University

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Shanghai Jiao Tong University

Sun Yat-sen University

Wuhan University of Technology

East China University of Science and Technology

Sichuan University

Sir Run Run Shaw Hospital

Kunming University of Science and Technology

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Compressive strength and permeability of steam-cured mortar incorporating high volume fly ash with different activation degrees by wet milling

Journal of Building Engineering (2022)

Jianxiang Huang Xingyang He Shouwei Jian Ying Su Hongbo Tan

Cementitious

10.1016/j.jobe.2022.104767

Cite

Citations (3)

Molecular level precision and high molecular weight peptide dendrimers for drug-specific delivery

Journal of Materials Chemistry B (2021)

Xinhao Fang Kai Gao Jianxiang Huang Kexin Liu Linying Chen

Here we report the liquid-phase synthesis of molecular level precision and amino-acids built-in polylysine dendrimers with high molecular weights. The strategy can produce tailor-made functional peptide dendrimers for diverse biomedical applications.

Polylysine

Molecular mass

10.1039/d1tb01157j

Cite

Citations (11)

Novel Inhibitory Role of Fenofibric Acid by Targeting Cryptic Site on the RBD of SARS-CoV-2

Biomolecules (2023)

Jianxiang Huang Chun Chan Ruhong Zhou

The emergence of the recent pandemic causing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created an alarming situation worldwide. It also prompted extensive research on drug repurposing to find a potential treatment for SARS-CoV-2 infection. An active metabolite of the hyperlipidemic drug fenofibrate (also called fenofibric acid or FA) was found to destabilize the receptor-binding domain (RBD) of the viral spike protein and therefore inhibit its binding to human angiotensin-converting enzyme 2 (hACE2) receptor. Despite being considered as a potential drug candidate for SARS-CoV-2, FA’s inhibitory mechanism remains to be elucidated. We used molecular dynamics (MD) simulations to investigate the binding of FA to the RBD of the SARS-CoV-2 spike protein and revealed a potential cryptic FA binding site. Free energy calculations were performed for different FA-bound RBD complexes. The results suggest that the interaction of FA with the cryptic binding site of RBD alters the conformation of the binding loop of RBD and effectively reduces its binding affinity towards ACE2. Our study provides new insights for the design of SARS-CoV-2 inhibitors targeting cryptic sites on the RBD of SARS-CoV-2.

Drug repositioning

Repurposing

10.3390/biom13020359

Cite

Citations (3)

CCDC 2079394: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Jianxiang Huang He Zhao Shu‐Qin Liu Jian‐Jun Zhang

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc27ss72

Cite

Citations (0)

Experimental Synthesis of Polyacrylic-Type Superabsorbent Polymer and Analysis of Its Internal Curing Performances

Fluid dynamics & materials processing (2021)

Jin Yang Wen Liang Xingyang He Ying Su Fulong Wang

A solution polymerization method has been used to synthesize a polyacrylic-type superabsorbent polymer (SAP). The influence of various influential factors, such as the temperature, neutralization degree, cross-linking agent, and initiator, on the water absorption capacity of SAP has been investigated. The results show that the absorption can display a non-monotonic behavior depending on the synthesis conditions. The absorption can also change according to the pH, ion types and ion concentration. As the pH value increases, the water absorption capacity decreases significantly. It also decreases if the Na+ concentration becomes higher and becomes particularly low in solutions containing Mg2+. With the addition of SAP, the compressive strength of cement mortar decreases; the internal relative humidity can be maintained at 96% within 200 hours; and autogenous shrinkage can be reduced by nearly 69%.

Superabsorbent polymer

Polyacrylic acid

Shrinkage

10.32604/fdmp.2022.018135

Cite

Citations (3)

Three-Layer Nested Wrf-Cfd-Based Downscaling Method for Accurately Modeling Pedestrian Wind in an Urban Context

SSRN Electronic Journal (2022)

Chenyu Huang Jiawei Yao Bin Fu John Kaiser Calautit Cairong Zhao

Computational fluid dynamics (CFD) techniques have received widespread acceptance in predicting pedestrian wind. The primary impediment to establishing a reliable inflow wind profile is the lack of on-site measurement data. We propose a downscaling method for accurately modeling pedestrian wind in the absence of on-site measurement data. The downscaling method consists of three layers of nested WRF (Weather Research and Forecasting)-CFD numerical simulations. The WRF model in layer one was used to acquire mesoscale data across the study site and to define the boundary conditions for the nested microscale domains. Another two layers of CFD calculations were performed at microscales via parametric modeling and full-information modeling to ensure a smooth transition of the downscaled information. To eliminate the effects of high-rise buildings, three potential mesoscale data heights were examined as CFD inputs. The accuracy of the downscaling method was validated using long-term on-site measurement data. The microscale simulation results using mesoscale and measurement data as the inlet boundary conditions were compared, and recommended to employ mesoscale data at a height of 200 m as an input to the CFD model for pedestrian wind modeling in complicated urban contexts.

10.2139/ssrn.4053648

Cite

Citations (0)

A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ via enhancement of tumor hypoxia levels

Nanoscale (2022)

Panli Han Lianxue Zhang Yaqi Fu FU You-yu Jianxiang Huang

The selective anti-tumor activity and less toxic nature of hypoxia-activated prodrugs including tirapazamine (TPZ) are harbored by hypoxia levels in tumors, the inadequacy of which leads to failure in clinical trials. Thus, the development of effective clinical applications of TPZ requires advanced strategies to intensify hypoxia levels in tumors effectively and safely. In this study, we designed and fabricated a paclitaxel (PTX)-loaded dual-response delivery system with a low dose (e.g., 2 Gy) of X-ray and reactive oxygen species on the basis of diselenide block copolymers. Upon the external X-ray stimulus, the system accurately released encapsulated PTX at tumor sites and remarkably improved tumor hypoxia levels by causing severe damage to tumor blood vessels. Subsequently, these enhanced tumor hypoxia levels effectively activated the reduction of TPZ into benzotriazinyl free radicals, which significantly improved the antitumor efficacy of our system against 4T1 breast cancer cells with an initial tumor volume of 500 mm3. Moreover, the dual-stimulus coordinated and controlled release of PTX was found to largely avoid the off-target effects of PTX on normal cells while exhibiting very limited side effects in experimental mice. The current novel strategy for regulating tumor hypoxia levels offers an effective and safe way to activate TPZ for the treatment of large solid tumors.

Tirapazamine

Tumor Hypoxia

Hypoxia

10.1039/d2nr04021b

Cite

Citations (6)

Eco-friendly treatment of low-calcium coal fly ash for high pozzolanic reactivity: A step towards waste utilization in sustainable building material

Journal of Cleaner Production (2019)

Jin Yang Jianxiang Huang Ying Su Xingyang He Hongbo Tan

Pozzolanic activity

Ettringite

Pozzolanic reaction

Bituminous coal

Environmentally Friendly

Wet-milling

10.1016/j.jclepro.2019.117962

Cite

Citations (205)

Fluorine Ion Contained Polyionic Liquid Membranes with Improved Anion Selectivity and Co2/N2 Separation Property

Dongyun Wei Yongli Shen Jianxiang Huang Yanli Chen Qibo Deng

Fluorine

10.2139/ssrn.5149174

Cite

Citations (0)

Probing the electrostatic aggregation of nanoparticles with oppositely charged molecular ions

Aggregate (2023)

Jianxiang Huang Damiano Buratto Ruhong Zhou

Abstract The co‐assembly of charged nanoparticles with oppositely charged molecular ions has emerged as a promising technique in the fabrication of nanoparticle superstructures. However, the underlying mechanism behind these molecular ions in mediating the repulsion between these charged nanoparticles remains elusive. Herein, coarse‐grained molecular dynamics simulations are used to elucidate the effects of valency, shape, and size of molecular anions on their co‐assembly with gold nanoparticles coated with positively charged ligands. The findings suggest that the valency, shape, and size of molecular anions significantly influence the repulsion and aggregating dynamics among these positively charged nanoparticles. Moreover, the free energy calculations reveal that ring‐shaped molecular anions with higher valences and larger sizes are more effective at reducing the repulsion between these gold nanoparticles and thus enhance the stability of the aggregate. This study contributes to a better understanding of the critical roles of valence, shape, and size of ions in mediating the electrostatic co‐assembly of nanoparticles with oppositely charged ions, and it also guides the future design of DNA templates and DNA origami in co‐assembly with oppositely charged nanoparticles.

Valency

Electrostatics

Electrostatic interaction

10.1002/agt2.324

Cite

Citations (2)