Sina M. Hopff

University Hospital Cologne

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Jörg Janne Vehreschild

University Hospital Cologne

Peter U. Heuschmann

Universitätsklinikum Würzburg

Thomas Bahmer

German Center for Lung Research

Olga Miljukov

University of Würzburg

Michael Krawczak

Kiel University

Dagmar Krefting

Universitätsmedizin Göttingen

Katharina S. Appel

Goethe University Frankfurt

Lazar Mitrov

University Hospital Cologne

Jens‐Peter Reese

University of Würzburg

Lilian Krist

Charité - Universitätsmedizin Berlin

Cooperative Institutions

Jena University Hospital

139

Friedrich Schiller University Jena

137

Charité - Universitätsmedizin Berlin

101

German Center for Infection Research

University of Cologne

Freie Universität Berlin

Ludwig-Maximilians-Universität München

Heinrich Heine University Düsseldorf

Humboldt-Universität zu Berlin

University of Würzburg

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Post-COVID Syndrome and health-related quality of life (HrQoL): A prospective, population-based study

Authorea (Authorea) (2024)

Christian Neumann Tim J. Hartung Klara Boje Thomas Bahmer Julian Keil

Long-term changes in health-related quality of life (HrQoL) after SARS-CoV-2 infection are common, but the causes and consequences of these changes are not well understood. HrQoL was assessed using the European Quality-of-Life-5-Dimensions-5-Level-Version (EQ-5D-5L) in 2,618 participants (56% female; aged 18–88 years) approximately 9 months (baseline) and 26 months (follow-up) after their first infection. The results were compared to 40 different demographic and clinical variables. A clinically important improvement in HrQoL was noted during the observation period. At baseline, the number of remaining symptoms from the infection (RS), fatigue (FACIT-Fatigue Scale), depressive symptoms (PHQ-8), muscle pain, age, and anxiety (GAD-7) explained 43% of the variance in HrQoL. At follow-up, fatigue, RS, depressive symptoms, anxiety, and muscle pain explained 50% of the variance. Although changes in fatigue, depressive symptoms, anxiety, and RS were associated with a change in HrQoL, the predictive value of the variables was virtually zero. The study suggests that HrQoL improves statistically significantly during the observation period. However, the extent of recovery is difficult to predict from concurrent changes in demographic and clinical variables. Besides a high RS number, fatigue is the main predictor of poor HrQoL after infection, followed by the presence of depressive and anxiety symptoms.

Depression

10.22541/au.172464977.75584057/v1

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Occurrence and clinical correlates of SARS-CoV-2 viremia in two German patient cohorts

Emerging Microbes & Infections (2025)

Katharina Grikscheit Annemarie Berger Holger F. Rabenau Niko Kohmer Katharina S. Appel

Viremia defined as detectable SARS-CoV-2 RNA in the blood is a potential marker of disease severity and prognosis in COVID-19 patients. Here, we determined the frequency of viremia in serum of two independent COVID-19 patient cohorts within the German National Pandemic Cohort Network (German: Nationales Pandemie Kohorten Netzwerk, NAPKON) with diagnostic RT-PCR against SARS-CoV-2. A cross-sectional cohort with 1,122 COVID-19 patients (German: Sektorenuebergreifende Platform, SUEP) and 299 patients recruited in a high-resolution platform with patients at high risk to develop severe courses (German: Hochaufloesende Plattform, HAP) were tested for viremia. Our study also involved a comprehensive analysis and association of serological, diagnostic and clinical parameters of the NAPKON medical dataset. Prevalence of viremia at the recruitment visit was 12,8% (SUEP) and 13% (HAP) respectively. Serological analysis revealed that viremic patients had lower levels of SARS-CoV-2 specific antibodies as well as lower neutralizing antibodies compared to aviremic patients. Viremia was associated with severity (<0.0001 SUEP; 0.002 HAP) and mortality of COVID-19 (both cohorts <0.0001) compared to aviremic patients. While rare, viremia was also detected in patients with mild disease (0.7%). In patients of the SUEP cohort with acute kidney disease (p = 0.0099) and hematooncological conditions (p = 0.0091), viremia was detected more frequently. Compared to the aviremic group, treatment with immunomodulating drugs as well as elevated levels of inflammatory markers in the blood was more frequent in the viremic group. In conclusion, our analysis revealed that detectable viremia correlates with hyperinflammatory conditions and higher risk for severe COVID-19 disease.

Viremia

2019-20 coronavirus outbreak

10.1080/22221751.2025.2459137

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B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner

ACS Omega (2022)

Andreas Stein Persefoni Hilken née Thomopoulou Corazon Frias Sina M. Hopff Paloma F. Varela

Colchicine, the main active alkaloid from Colchicum autumnale L., is a potent tubulin binder and represents an interesting lead structure for the development of potential anticancer chemotherapeutics. We report on the synthesis and investigation of potentially reactive colchicinoids and their surprising biological activities. In particular, the previously undescribed colchicinoid PT-100, a B-ring contracted 6-exo-methylene colchicinoid, exhibits extraordinarily high antiproliferative and apoptosis-inducing effects on various types of cancer cell lines like acute lymphoblastic leukemia (Nalm6), acute myeloid leukemia (HL-60), Burkitt-like lymphoma (BJAB), human melanoma (MelHO), and human breast adenocarcinoma (MCF7) cells at low nanomolar concentrations. Apoptosis induction proved to be especially high in multidrug-resistant Nalm6-derived cancer cell lines, while healthy human leukocytes and hepatocytes were not affected by the concentration range studied. Furthermore, caspase-independent initiation of apoptosis via an intrinsic pathway was observed. PT-100 also shows strong synergistic effects in combination with vincristine on BJAB and Nalm6 cells. Cocrystallization of PT-100 with tubulin dimers revealed its (noncovalent) binding to the colchicine-binding site of β-tubulin at the interface to the α-subunit. A pronounced effect of PT-100 on the cytoskeleton morphology was shown by fluorescence microscopy. While the reactivity of PT-100 as a weak Michael acceptor toward thiols was chemically proven, it remains unclear whether this contributes to the remarkable biological properties of this unusual colchicinoid.

Colchicine

10.1021/acsomega.1c04659

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Predictors of non-recovery from fatigue and cognitive deficits after COVID-19: a prospective, longitudinal, population-based study

EClinicalMedicine (2024)

Tim J. Hartung Thomas Bahmer Irina Chaplinskaya-Sobol Jürgen Deckert Matthias Endres

Despite the high prevalence and major disability associated with fatigue and cognitive deficits after SARS-CoV-2 infection, little is known about long-term trajectories of these sequelae. We aimed to assess long-term trajectories of these conditions and to identify risk factors for non-recovery.

Montreal Cognitive Assessment

Longitudinal Study

10.1016/j.eclinm.2024.102456

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Citations (24)

Fatigue and cognitive impairment after COVID-19: A prospective multicentre study

EClinicalMedicine (2022)

Tim J. Hartung Christian Neumann Thomas Bahmer Irina Chaplinskaya-Sobol Matthias Endres

Depression

Montreal Cognitive Assessment

myalgia

10.1016/j.eclinm.2022.101651

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Citations (133)

The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics

European Journal of Epidemiology (2022)

Maximilian Schons Lisa Pilgram Jens‐Peter Reese Melanie Stecher Gabriele Anton

The German government initiated the Network University Medicine (NUM) in early 2020 to improve national research activities on the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic. To this end, 36 German Academic Medical Centers started to collaborate on 13 projects, with the largest being the National Pandemic Cohort Network (NAPKON). The NAPKON's goal is creating the most comprehensive Coronavirus Disease 2019 (COVID-19) cohort in Germany. Within NAPKON, adult and pediatric patients are observed in three complementary cohort platforms (Cross-Sectoral, High-Resolution and Population-Based) from the initial infection until up to three years of follow-up. Study procedures comprise comprehensive clinical and imaging diagnostics, quality-of-life assessment, patient-reported outcomes and biosampling. The three cohort platforms build on four infrastructure core units (Interaction, Biosampling, Epidemiology, and Integration) and collaborations with NUM projects. Key components of the data capture, regulatory, and data privacy are based on the German Centre for Cardiovascular Research. By April 01, 2022, 34 university and 40 non-university hospitals have enrolled 5298 patients with local data quality reviews performed on 4727 (89%). 47% were female, the median age was 52 (IQR 36-62-) and 50 pediatric cases were included. 44% of patients were hospitalized, 15% admitted to an intensive care unit, and 12% of patients deceased while enrolled. 8845 visits with biosampling in 4349 patients were conducted by April 03, 2022. In this overview article, we summarize NAPKON's design, relevant milestones including first study population characteristics, and outline the potential of NAPKON for German and international research activities.Trial registration https://clinicaltrials.gov/ct2/show/NCT04768998 . https://clinicaltrials.gov/ct2/show/NCT04747366 . https://clinicaltrials.gov/ct2/show/NCT04679584.

Pandemic

10.1007/s10654-022-00896-z

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Citations (41)

Onkologische Versorgungsforschung in Deutschland

Forum (2021)

Daniel Medenwald Andrea Schmidt‐Pokrzywniak Lorenz A. Kapsner Nina Buttmann-Schweiger Sina M. Hopff

2019-20 coronavirus outbreak

10.1007/s12312-021-00996-z

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Citations (1)

Sensitizing multidrug-resistant leukemia cells to common cytostatics by an aluminium-salen complex that has high-apoptotic effects in leukemia, lymphoma and mamma carcinoma cells

BioMetals (2021)

Sina M. Hopff Liliane A. Onambele M. Brandenburg Albrecht Berkessel Aram Prokop

Daunorubicin

10.1007/s10534-020-00273-x

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Citations (1)

Clostridioides difficile infection (CDI): A pan-European multi-center cost and resource utilization study, results from the Combatting Bacterial Resistance in Europe CDI (COMBACTE-CDI)

Clinical Microbiology and Infection (2022)

Sebastian Wingen‐Heimann Kerrie Davies Virginie Viprey Georgina Davis Mark H. Wilcox

Clostridioides

10.1016/j.cmi.2022.12.019

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Citations (27)

NAPKON Public Use File

Zenodo (CERN European Organization for Nuclear Research) (2022)

NAPKON Study Group Carolin E. M. Jakob Sina M. Hopff Thierry Meurers Chin Huang Lee

Anonymized Public Use File of the National Pandemic Cohort Network (NAPKON), a German cohort studying the epidemiology and clinical course of SARS-CoV-2 infected patients. For more information see https://napkon.de/

10.5281/zenodo.6576177

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Citations (1)