Edita Jašinskienė

Lithuanian University of Health Sciences

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Dalia Marčiulionytė

Lithuanian University of Health Sciences

Rimantė Dobrovolskienė

Lithuanian University of Health Sciences

Rasa Verkauskienė

Lithuanian University of Health Sciences

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Žilvinas Padaiga

Lithuanian University of Health Sciences

Ingrida Stankutė

Lithuanian University of Health Sciences

Giedrė Mockevičienė

Hospital of Lithuanian University of Health Sciences Kaunas Clinics

Evalda Danytė

Lithuanian University of Health Sciences

Vaiva Sadauskaitė‐Kuehne

Lithuanian University of Health Sciences

Valérie Schwitzgebel

University of Geneva

Johnny Ludvigsson

Linköping University

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Lithuanian University of Health Sciences

Hospital of Lithuanian University of Health Sciences Kaunas Clinics

Institute of Endocrinology

Kaunas University of Technology

Vilnius University

Vilnius University Hospital Santariskiu Klinikos

University Hospital of Geneva

University of Geneva

Diabetes Australia

Hôpital Beau-Séjour

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Feeding in infancy and risk of childhood pre-diabetes in Lithuania

Erika Skrodenienė Edita Jašinskienė Dalia Marčiulionytė Margarita Valūnienė

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Factors Affecting Cardiovascular Risk in Children, Adolescents, and Young Adults with Type 1 Diabetes

Journal of Diabetes Research (2019)

Ingrida Stankutė Rimantė Dobrovolskienė Evalda Danytė Dovilė Ražanskaitė-Virbickienė Edita Jašinskienė

Cardiovascular risk and obesity are becoming major health issues among individuals with type 1 diabetes (T1D). The aim of this study was to evaluate cardiovascular risk factors and obesity in youth with T1D in Lithuania. Methods . 883 patients under 25 years of age with T1D for at least 6 months were investigated. Anthropometric parameters, blood pressure, and microvascular complications were evaluated, and the lipid profile and HbA1c were determined for all patients. Results . Study subjects’ mean HbA1c was 8.5±2%; 19.5% were overweight and 3.6% obese. Hypertension and dyslipidemia were diagnosed in 29.8% and 62.6% of participants, respectively. HbA1c concentration was directly related to levels of total cholesterol (r=0.274, p<0.001), LDL (r=0.271, p<0.001), and triglycerides (r=0.407, p<0.001) and inversely associated with levels of HDL (r=0.117, p=0.001). Prevalence of dyslipidemia increased with duration of diabetes (p<0.05). Hypertension was more prevalent in overweight and obese compared to normal-weight patients (40.6 and 65.6 vs. 25.6%, respectively, p<0.001). Frequency of microvascular complications was higher among patients with dyslipidemia (27.2 vs. 18.8%, p=0.005) and among those with hypertension (25.9 vs. 23.2%, p<0.001). Conclusion . The frequency of cardiovascular risk factors is high in youth with T1D and associated with diabetes duration, obesity, and metabolic control.

Dyslipidemia

10.1155/2019/9134280

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Endokrininių ligų diagnostikos ir gydymo algoritmai : mokomoji knyga

Agnė Abraitienė Dalia Adukauskienė Stasys Auškalnis Lina Barsienė Inga Arūnė Bumblytė

Aprobavo Lietuvos sveikatos mokslų universiteto Medicinos akademijos Medicinos fakulteto taryba 2019-10-23 Protokolo Nr. 72/2019 ir LSMU Leidybos komisija 2019-11-06 Protokolo Nr. 22/2019

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Vaikų cukrinio diabeto diagnostika

Edita Jašinskienė

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Longer breastfeeding is an independent protective factor against development of type 1 diabetes mellitus in childhood

Diabetes/Metabolism Research and Reviews (2004)

Vaiva Sadauskaitė‐Kuehne Johnny Ludvigsson Žilvinas Padaiga Edita Jašinskienė Ulf Samuelsson

Abstract Background Early weaning diet, early introduction of breast milk substitution and cow's milk have been shown to increase the risk of type 1 diabetes later in life. It is also shown that older maternal age, maternal education, preeclampsia, prematurity, neonatal illness and neonatal icterus caused by blood group incompatibility, infections and stress might be risk factors for type 1 diabetes. We aimed to determine whether early nutrition is an independent risk factor for diabetes despite other life events. Methods Data from 517 children (268 boys and 249 girls) in south‐east of Sweden and 286 children (133 boys and 153 girls) in Lithuania in the age group of 0 to 15 years with newly diagnosed type 1 diabetes mellitus were included into analysis. Three age‐ and sex‐matched healthy controls were randomly selected. Response rate in control families in Sweden was 72.9% and in Lithuania 94.8%. Information was collected via questionnaires. Results Exclusive breastfeeding longer than five months (odds ratio 0.54, 95% confidence interval 0.36–0.81) and total breastfeeding longer than 7 (0.56, 0.38–0.84) or 9 months (0.61, 0.38–0.84), breastfeeding substitution that started later than the third month (0.57, 0.33–0.98) among Swedish children 5 to 9 years old and later than the seventh month (0.24, 0.07–0.84) among all Swedish children is protective against diabetes when adjusted for all other above‐listed risk factors. In Lithuania, exclusive breastfeeding longer than two months in the age group of 5 to 9 years is protective (0.58, 0.34–0.99) when adjusted for other factors. Conclusions Longer exclusive and total breastfeeding appears as an independent protective factor against type 1 diabetes. Copyright © 2004 John Wiley & Sons, Ltd.

Protective factor

10.1002/dmrr.425

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Evaluation of β-cell Function in Young MODY Patients using a Mixed Meal Tolerance Test

58th Annual ESPE Meeting (ESPE 2019) (2019)

Ingrida Stankutė Aušra Morkūnaitė Rimantė Dobrovolskienė Evalda Danytė Dovilė Ražanskaitė-Virbickienė

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Thirty-Five Years of Thyroid Cancer Experience in a Paediatric Population: Incidence Trends in Lithuania between 1980 and 2014

European Thyroid Journal (2016)

Rima Bėrontienė Edita Jašinskienė Rosita Kiudelienė Gintaras Kuprionis Jurgita Makštienė

Thyroid cancer (TC) is a rare condition in children. It may be associated with radiation, iodine deficiency or familial inheritance.The objectives of this study were to analyse the prevalence and incidence trends over 3 decades and clinical features of TC in the paediatric population in Lithuania.We reviewed all TC cases diagnosed in children aged less than 18 years during the period 1980-2014 using medical records from 3 main hospitals in Lithuania where such TC cases are managed.During the 35-year period (1980-2014) there were 57 cases (45 females) of TC in children in Lithuania. The mean age at the time of diagnosis was 14.51 ± 0.52 years. The crude incidence rate of TC ranged from 0 to 0.93 cases per 100,000 children per year and the mean annual increase was 5.26% (p < 0.001). Papillary carcinoma was the most common histological type (73.7%). No association was found between the incidence of TC and the reported areas of radioactive contamination after the Chernobyl accident. In total, 8.8% of patients had secondary TC after initial radiotherapy of a primary oncologic disease.The incidence of TC in the Lithuanian paediatric population between 1980 and 2014 ranged from 0 to 0.93 cases per 100,000 children per year and there was a 5.26% annual increase (p < 0.001), most probably related to the increased use of ultrasound testing.

10.1159/000450921

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Lietuvos vaikų, sergančių 1 tipo cukriniu diabetu, pirmos ir antros eilės giminaičių sergamumas diabetu (1 ir 2 tipo) ir kai kuriomis autoimuninėmis ligomis (1996-2000 metų duomenimis)

Edita Jašinskienė Vaiva Sadauskaitė‐Kuehne Žilvinas Padaiga Bronislava Urbonaitė Johnny Ludvigsson

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First case of Hajdu-Cheney syndrome in Lithuania caused by novel NOTCH2 gene likely pathogenic variant

European Journal of Medical Genetics (2024)

Ieva Tėvelytė Paulius Bertašius Kristina Aleknavičienė Rimvydas Jonikas Justina Klimaitė

Hajdu-Cheney syndrome (HCS) is an extremely rare autosomal dominant skeletal disorder. The prevalence rate of less than 1 case per 1,000,000 newborns and only 50 cases were reported in the medical literature. HCS is characterized by progressive bone resorption in the distal phalanges (acro-osteolysis), progressive osteoporosis, distinct craniofacial changes, dental anomalies, and occasional association with renal abnormalities. HCS is caused by pathogenic variants in the NOTCH2 gene, 34th exon. We report first familial case of HCS caused by likely pathogenic variant of NOTCH2 gene c.6449delC, p.(Pro2150LeufsTer5).

Craniofacial abnormality

10.1016/j.ejmg.2024.104938

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Glucose tolerance, insulin resistance and lipid profile in adolescents born either small or appropriate for gestational age

Indrė Petraitienė Edita Jašinskienė Audronė Šeibokaitė Kerstin Albertsson Wikland Rasa Verkauskienė

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