Julie Bailey

Waltham Centre for Pet Nutrition

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Peter J. Markwell

MaRS

Adrian Watson

Bouygues (France)

Tim R. Fray

Waltham Centre for Pet Nutrition

Claire D. Baker

Waltham Centre for Pet Nutrition

Julie Croft

University of Leeds

Leonard J. Cole

Kettering General Hospital

Timothy R. Fray

Waltham Centre for Pet Nutrition

Nicola Sirel

Waltham Centre for Pet Nutrition

W. W. Reenstra

University of California, Berkeley

Karl F. Swingle

University of California, Irvine

Cooperative Institutions

Waltham Centre for Pet Nutrition

University of Richmond

University of Leeds

United States Army Aeromedical Research Lab

University of Pennsylvania

National Institutes of Health

University of California, Berkeley

University of California, San Francisco

Royal Veterinary College

Ayuntamiento de Bilbao

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AHR-9294: a novel inhibitor of H,K-ATPase antagonizes gastric HCl secretion in vivo.

Journal of Pharmacology and Experimental Therapeutics (1992)

W. W. Reenstra Lawrence M. Pinkus Julie Bailey William L. Smith David A. Droppleman

8-Methoxy-4-[(2-isopropylphenyl)amino]-3-quinolinecarboxylate ethyl ester (AHR-9294) inhibited acid secretion stimulated by histamine, pentagastrin or carbachol in rats, and by histamine or feeding in dogs. AHR-9294 was about half as potent as omeprazole and exhibited a shorter duration of action. Based on its inhibition of acid secretion induced by different secretagogues and its lack of effect on histamine-stimulated adenylate cyclase activity, AHR-9294 does not appear to operate at the histamine receptor or adenylate cyclase. Rather, studies on enriched oxyntic microsomal preparations showed AHR-9294 to be an effective inhibitor of the H+ pump enzyme, H,K-ATPase, suggesting this might be the site of antisecretory activity. Kinetic studies revealed that inhibition of both K(+)-activated ATPase and p-nitrophenylphosphatase by AHR-9294 was purely competitive with K+ and its congeners, indicating that AHR-9294 and its analogs belong to the class of compounds known as "K+)-site" inhibitors. On the other hand, inhibition by AHR-9294 was noncompetitive with both ATP and p-nitrophenylphosphatase on their respective rates of hydrolysis (i.e., both Vmax and the apparent Km were reduced, but Vmax/Km was unchanged). Studies on partial reactions of the H,K-ATPase showed that the rate of ATP/ADP exchange was unaffected by AHR-9294 and the steady-state level of phosphoenzyme was only partially reduced (thus ATP/enzyme interaction was not affected); however, the rate of K(+)-catalyzed dephosphorylation of phosphoenzyme was markedly decreased.(ABSTRACT TRUNCATED AT 250 WORDS)

Dephosphorylation

10.1016/s0022-3565(25)11099-9

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Citations (4)

Association of neutral deoxyribonuclease with chromatin isolated from mammalian cells

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis (1967)

Karl F. Swingle Leonard J. Cole Julie Bailey

Deoxyribonucleases

Nucleoprotein

Divalent

Nuclear DNA

10.1016/0005-2787(67)90174-8

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Citations (24)

A Combination of Aloe Vera, Curcumin, Vitamin C, and Taurine Increases Canine Fibroblast Migration and Decreases Tritiated Water Diffusion across Canine Keratinocytes In Vitro

Journal of Nutrition (2004)

Timothy R. Fray Adrian Watson Julie Croft Claire D. Baker Julie Bailey

Aloe Vera

10.1093/jn/134.8.2117s

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Dietary constituents are able to play a beneficial role in canine epidermal barrier function

Experimental Dermatology (2005)

Adrian Watson Tim R. Fray Julie Bailey Claire B. Baker Sally A. Beyer

Epidermal barrier function is a critical attribute of mammalian skin. The barrier is responsible for preventing skin-associated pathologies through controlling egress of water and preventing ingress of environmental agents. Maintaining the quality and integrity of the epidermal barrier is therefore of considerable importance. Structurally, the barrier is composed of two main parts, the corneocytes and the intercellular lamellar lipid. The epidermal lamellar lipid comprises mainly ceramides, sterols and fatty acids. Twenty-seven nutritional components were screened for their ability to upregulate epidermal lipid synthesis. Seven of the 27 nutritional components (pantothenate, choline, nicotinamide, histidine, proline, pyridoxine and inositol) were subsequently retested using an in vitro transepidermal diffusion experimental model, providing a functional assessment of barrier properties. Ultimately, the best performing five nutrients were fed to dogs at supplemented concentrations in a 12-week feeding study. Barrier function was measured using transepidermal water loss (TEWL). It was found that a combination of pantothenate, choline, nicotinamide, histidine and inositol, when fed at supplemented concentrations, was able to significantly reduce TEWL in dogs after 9 weeks.

Transepidermal water loss

Barrier function

Lamellar granule

Corneocyte

Niacin

10.1111/j.0906-6705.2005.00385.x

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Citations (37)

A high yield method for growing primary canine keratinocytes

The Veterinary Journal (2003)

Adrian Watson Claire D. Baker Julie Bailey Tim R. Fray Peter J. Markwell

Clonogenic assay

Cholera toxin

10.1016/s1090-0233(03)00117-5

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Citations (7)