Maryam Khodamian

Zahedan University of Medical Sciences

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Saeedeh Salimi

Zahedan University of Medical Sciences

Azam Hajizadeh

National Institute of Genetic Engineering and Biotechnology

Kimia Fazeli

Zahedan University of Medical Sciences

Minoo Yaghmaei

Shahid Beheshti University of Medical Sciences

Atefeh Pejman

Zahedan University of Medical Sciences

Atefeh Yazdi

Zahedan University of Medical Sciences

Lida Namazi

Zahedan University of Medical Sciences

Mojgan Mokhtari

Iran University of Medical Sciences

Soodabeh Rezaee

Zahedan University of Medical Sciences

Mojtaba Sajadian

Rafsanjan University of Medical Sciences

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Zahedan University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Iran University of Medical Sciences

National Institute of Genetic Engineering and Biotechnology

Milad Hospital

Cellular Research (United States)

Shaheed Rajaei Cardiovascular Medical and Research Center

Sydney South West Area Health Service

Islamic Azad University North Tehran Branch

K.N.Toosi University of Technology

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Association of polymorphisms and haplotypes in the cytochrome P450 1B1 gene with uterine leiomyoma: A case control study

Biomedical Reports (2014)

Saeedeh Salimi Maryam Khodamian Mehrnaz Narooie-Nejad Azam Hajizadeh Kimia Fazeli

Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus and estrogen metabolizing enzymes affect its promotion and progression. The aim of the present study was to evaluate the association between four single-nucleotide polymorphisms (SNPs) of the cytochrome P450 1B1 (CYP1B1) gene and UL risk. Four SNPs of the CYP1B1 gene in 105 UL patients and 112 unrelated healthy controls were genotyped using a direct sequencing method. Haplotype analyses were performed with UNPHASED software and linkage disequilibrium (LD) was assessed by Haploview software. There were no associations between Leu432Val (rs1056836), Asp449Asp (rs1056837) and Asn453Ser (rs1800440) polymorphisms of the CYP1B1 gene and UL. Although the genotypic frequencies of the Arg368His (rs79204362) polymorphism did not differ between the two groups, the frequency of A (His) allele was significantly higher in UL females (P=0.02). In addition, the frequency of GTAA haplotype was significantly higher in the controls and played a protective role in UL susceptibility. A strong LD between the three common SNPs (rs1056836, rs1056837 and rs1800440) in the CYP1B1 gene was observed in the population. In conclusion, a higher frequency of the CYP1B1 368His (A) allele was observed in UL females. The frequency of the GTAA haplotype was significantly higher in healthy females and this haplotype played a protective role in UL susceptibility.

Linkage Disequilibrium

CYP1B1

Genetic Association

Minor allele frequency

SNP

10.3892/br.2014.413

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Citations (8)

Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study

Bosnian Journal of Basic Medical Sciences (2016)

Saeedeh Salimi Mojtaba Sajadian Maryam Khodamian Atefeh Yazdi Soodabeh Rezaee

Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus, and estrogen metabolizing enzymes affect its progression. This study aimed to evaluate the association between two single-nucleotide polymorphisms of cytochrome P450 1A1 (CYP1A1) gene and UL risk. The study consisted of 105 patients with UL and 112 healthy women as controls. Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene were analyzed by DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism methods, respectively. The findings indicated no association between Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene and UL (p < 0.05). However, the combination effect of TT/AG genotypes of the Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms was associated with 4.3-fold higher risk of UL. In addition, haplotype analysis revealed that TG haplotype of the Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms could increase the UL risk nearly 4.9-fold. Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms of CYP1A1 gene were not associated with UL susceptibility; however, the combination of the TT/AG genotypes and TG haplotype could increase the UL risk.

Uterine Leiomyoma

10.17305/bjbms.2016.1245

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Age-dependent association of MDM2 promoter polymorphisms and uterine leiomyoma in South-East Iran: A preliminary report

Journal of Obstetrics and Gynaecology Research (2014)

Saeedeh Salimi Azam Hajizadeh Maryam Khodamian Atefeh Pejman Kimia Fazeli

Abstract Aim Murine double minute clone 2 ( MDM2 ) is an important regulator of p53 tumor suppressor protein. Because increased MDM2 expression has been observed in different tumors, its polymorphisms are proposed to be associated with accelerated tumor formation. The aim of this study was to examine the association between T309G (rs2279744) and 40‐bp Insertion/deletion (rs3730485) polymorphisms of the MDM2 gene and risk of uterine leiomyoma ( UL ). Methods We analyzed the MDM2 gene polymorphisms of 154 UL patients and 197 healthy controls by polymerase chain reaction ( PCR ) or PCR restriction fragment length polymorphism ( RFLP ) methods. Results The frequency of MDM2 T309G polymorphism genotypes was not different between UL women and controls. Although there was an association between MDM2 40‐bp del/del genotype and UL before and after adjustment for age, the association between Insertion/deletion (Indel) genotype and UL was significant after adjustment for age. Conclusion MDM2 T309G polymorphism was not associated with UL and MDM2 40‐bp Indel polymorphism could be an age‐related risk factor for UL .

Uterine Leiomyoma

Association (psychology)

10.1111/jog.12625

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Citations (16)