Andreas Kourelis

Aristotle University of Thessaloniki

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Minas Yiangou

Aristotle University of Thessaloniki

Dimitrios Pilalas

AHEPA University Hospital

Charalampos Kotzamanidis

Centre for Research and Technology Hellas

E. Litopoulou‐Tzanetaki

Aristotle University of Thessaloniki

Ioanna Sakellari

G. Papanikolaou General Hospital

Isaia Symeonidou

Aristotle University of Thessaloniki

ΟT

Οlga Tsachouridou

Aristotle University of Thessaloniki

Maria Hatzistilianou

Aristotle University of Thessaloniki

Tasoula Touloumenidou

G. Papanikolaou General Hospital

Apostolia Papalexandri

G. Papanikolaou General Hospital

Cooperative Institutions

Aristotle University of Thessaloniki

AHEPA University Hospital

G. Papanikolaou General Hospital

National and Kapodistrian University of Athens

Democritus University of Thrace

University of Thessaly

Hippocration General Hospital

Alexion Pharma (Switzerland)

European Hematology Association

Centre National de la Recherche Scientifique

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Promoter Polymorphisms of the Canine SCL11A1 Gene are Correlated with Susceptibility to Canine Leishmaniosis

Acta veterinaria (2020)

Isaia Symeonidou Styliani Pappa Elias Papadopoulos Chrysostomos Ι. Dovas Andreas Kourelis

Abstract In enzootic areas the prevalence estimates of canine leishmaniosis are high whereas only a proportion of dogs exhibit the clinical disease, thus implying a role of host genetics. The type of the triggered immune response remains a crucial determining factor for the diverse outcome of this parasitosis. The Solute Carrier Family 11 member 1 (SLC11A1) is a protein, which plays a central role in macrophage function and is implicated in the regulation of the immune response. An extended study with 73 resistant and 75 susceptible to Leishmania dogs was conducted. A fragment of the promoter region of the canine SLC11A1 gene was amplified and digested providing the different genotypes for three previously recorded single-nucleotide polymorphisms (SNPs) (SNP1 T151C, SNP2 Α180G, SNP3 G318A) for each animal. Statistical analyses revealed that SNP2 Α180G in heterozygosity (AG) as well as SNP3 G318A in homozygosity (AA) are correlated with susceptibility to canine leishmaniosis.

10.2478/acve-2020-0023

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Comparing Abbott m2000 RealTime HIV test and Roche COBAS Ampliprep/COBAS Taqman HIV test, v2.0 in treated HIV‐1 B and non‐B subjects with low viraemia

Journal of Medical Virology (2015)

Apostolia Margariti Dimitrios Chatzidimitriou Symeon Metallidis Dimitrios Pilalas Andreas Kourelis

Viral load testing is a valuable tool in HIV clinical care and research. Discrepancies among diverse viral load assays, especially with regard to non-B HIV-1 subtypes have been reported. Our study aimed to explore the impact of HIV subtype (B versus non-B) on the agreement between CAP/CTM, v2.0 and m2000 RealTime in treated HIV patients, focusing on low viral loads (<200 copies/ml). Our findings indicate that there is a significant difference in the performance of the compared assays in the low-viremic range and non-B subtypes, suggesting that a single assay should be used for follow-up.

TaqMan

10.1002/jmv.24369

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Preliminary probiotic selection of dairy and human yeast strains.

Journal of Biological Research (2010)

Andreas Kourelis Charalampos Kotzamanidis E. Litopoulou‐Tzanetaki Zacharias G. Scouras Nikolaos Tzanetakis

Probiotics are bacteria or yeast cells that, after delivery into the gastrointestinal tract, exert beneficial effects to the host. Despite the occurrence of yeasts in many dairy related products and in the human gastrointestinal tract, their potential role as probiotics has been overlooked. In this study we evaluated the in vitro probiotic properties of yeast strains isolated from feta cheese or infants’ gastrointestinal tract. All strains tested (except one strain) contained no plasmid DNA and exhibited in vitro probiotic properties such as acid and bile tolerance, adhesion to Caco-2 cells, cholesterol removal ability and immunostimulatory activity. Thus, these are potential candidate strains to be used as gene delivery and expression systems for therapeutic or vaccination purposes as well as probiotics with the ability to decrease cholesterol levels. Moreover, we showed that besides the strains of the Saccharomyces genus other yeast species such as Kluyveromyces lactis may also be considered as presumptive probiotics. However, despite the above promising results, additional experimentation is required to examine the effects of these yeast strains in the gastrointestinal tract after their oral administration.

Human gastrointestinal tract

Saccharomyces boulardii

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High rates of transmitted drug resistance among newly-diagnosed antiretroviral naïve HIV patients in Northern Greece, data from 2009–2011

Clinical Microbiology and Infection (2012)

Lemonia Skoura Simeon Metallidis Dimitrios Pilalas Andreas Kourelis Antigoni Margariti

Antiretroviral drug

HIV drug resistance

Antiretroviral treatment

10.1111/1469-0691.12124

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West Nile Virus Seroprevalence and Behavioral Risks in HIV-1 Infected Individuals, Northern Greece, 2011

International Journal of Infectious Diseases (2014)

Dimitrios Pilalas Lemonia Skoura Symeon Metallidis Andreas Kourelis Οlga Tsachouridou

This study sought to assess the West Nile Virus (WNV) seroprevalence and behavioral risk factors for WNV infection in HIV-1 infected individuals in Northern Greece in 2011.We prospectively enrolled 91 HIV-1 consecutive patients followed up in the HIV clinic of the AHEPA University Hospital in the period from November to December 2011. Serum samples were tested for the presence of WNV IgG antibodies. All subjects were administered a standardized questionnaire to evaluate for risk factors for WNV infection.WNV IgG antibodies were detected in three subjects (3.3%, 95% CI 0.7-9.3%), two of whom were of African origin. The prevalence of WNV antibodies in HIV patients of Greek origin was 1.2% (95% CI: 0.03% - 6.3%). In the sample surveyed, 53.6% (95% CI: 42.4% to 64.5%) were aware of WNV prevention measures; 2.2% reported no implementation of prevention measures, whereas 46.1% implemented at least three measures. Approximately one half of the patients reported outdoor activities for more than two hours from dusk to dawn. None of the IgG-positive patients reported any symptoms compatible with WNV disease during the season at risk.Among native Greek HIV patients, the WNV seroprevalence is 1.2%. A considerable proportion of patients was aware of WNV prevention measures and implemented some of these. HIV patients and other categories of immunocompromised patients are at increased risk of neuroinvasive disease, and widespread implementation of prevention measures should be strongly encouraged in this patient population.

Seroprevalence

West Nile virus

10.1016/j.ijid.2014.10.010

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Evaluation of adhesion capacity, cell surface traits and immunomodulatory activity of presumptive probiotic Lactobacillus strains

International Journal of Food Microbiology (2010)

Charalampos Kotzamanidis Andreas Kourelis E. Litopoulou‐Tzanetaki Nikolaos Tzanetakis Minas Yiangou

10.1016/j.ijfoodmicro.2010.04.004

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Citations (153)

Humoral and T Cell Immune Responses to Sars-Cov-2 Vaccination in Hematopoietic Cell Transplant Recipients

Blood (2021)

Eleni Gavriilaki Αναστασία Παπαδοπούλου Tasoula Touloumenidou Fani Stavridou Evdoxia Koravou

ELISPOT

Immunosuppression

10.1182/blood-2021-149399

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Susceptibility and Resistance to Canine Leishmaniose is Associated to Polymorphisms of the Canine TNF-α Gene

European Journal of Inflammation (2011)

Isaia Symeonidou Maria Hatzistilianou Elias Papadopoulos Chrysostomos Ι. Dovas Evdokia Karagouni

The prevalence of canine leishmaniosis (CanL) infection in an enzootic area is considerably higher than the overall prevalence of the disease, suggesting a role of host genetics related to the outcome of the disease. It is accepted that one determining factor for the outcome of CanL is the type of the triggered immune response, which seems to be genetically determined. TNF-α is a cytokine which plays a crucial role during the immune response against Leishmania parasites. In the present study a case-control study with 20 resistant and 20 susceptible dogs was performed. The distribution of breeds was equal in both groups. By Sanger method the nucleotide sequence upstream the Open Reading Frame of the canine TNF-α gene was determined and four polymorphisms were identified (−40 C/A, −1134 T/G, −1150 T/C κα −1243 C/G). Statistical analysis showed that the polymorphism TNF-α −40 C/A is correlated with susceptibility to CanL, while the polymorphism TNF-α −1243 C/G is correlated with resistance to CanL. Further statistical analysis, regarding the possible correlation of gender as well as clinical manifestations of the disease with the above-mentioned polymorphisms of the TNF-α gene, showed no significant findings. Further analysis of the above polymorphisms, as well as identification of more polymorphisms in candidate genes, is required to provide a better understanding of the complex underlying immune response in CanL.

Canine leishmaniasis

10.1177/1721727x1100900104

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Citations (6)

Celiac-like disease induction by gluten in sensitised mice involves IgA, TfR1 and translutaminase 2 interactions

Christina Papista Renato C. Monteiro Laureline Berthelot Minas Yiangou Ivan Cruz Moura

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Microarray Analysis of NF-κB Signaling Pathways in PBMC of Mice Infected by Trichinella Spiralis

International Journal of Immunopathology and Pharmacology (2010)

Isaia Symeonidou Styliani Pappa Andreas Kourelis A. Anogeianaki Ilias Frydas

The NF-κB pathway gene expression profiles were compared between 10, 20 and 39 days after Trichinella spiralis experimental infection in BALB/c mice. Out of 128 genes, 19 (14.8%) genes were present in non-infected and post-infected mice. The expression of 7 (36.8%) genes was downregulated 10 and 20 days post-infection while 3 (15.8%) genes were upregulated 39 days post-infection. The present study lists the candidate genes of the NF-κB signaling pathway that were commonly and differentially expressed between the specific points of T. spiralis infection, thus suggesting that these genes need to be further investigated to reveal the mechanism of the T. spiralis modulation of the NF-κB signaling pathways.

Trichinella spiralis

10.1177/039463201002300317

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Citations (2)