K Oliveira

Johnson & Johnson (United States)

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I Nunes

Universidade Federal de São Paulo

Benedita Bianchi de Aguiar

Centro Hospitalar de Entre o Douro e Vouga E.P.E.

Miguel Costa

Universidade Federal do Paraná

Lúcia Gomes

Universidade Lusófona

Fernanda de Paula Ciribelli da Silva

Anton de Kom University of Suriname

ÃA

Ãngela Afonso

University of Lisbon

Mohamed Gabr

Brigham and Women's Hospital

Luana Izabela Azevedo de Carvalho

Universidade do Estado do Amazonas

Maria Lília Paiva Barbosa de Paula

Faculdade Brasil

Henrique Vieira Pereira

Universidade Federal do Amazonas

Cooperative Institutions

Universidade Federal do Amazonas

Centro Hospitalar de Entre o Douro e Vouga E.P.E.

Brigham and Women's Hospital

Harvard University

Universidade do Estado do Amazonas

Universidade Nilton Lins

Universidade Estadual Paulista (Unesp)

Grupo Hospitalar Conceição

Hospital Universitario de San Vicente Fundación

Universidade Federal de São Paulo

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Adenocarcinoma de Esôfago e Doença do Refluxo Gastroesofágico: Relação Patogênica e Implicações no Diagnóstico e Tratamento

Brazilian Journal of Implantology and Health Sciences (2024)

Myrella Lima Nunes Nobre Ana Paula Braga dos Santos Bárbara Mirelle de Oliveira Almeida Emanuela Caroline Moraes Holarya Germana Marques Melo

Este artigo de revisão integrativa explora a complexa relação entre a Doença do Refluxo Gastroesofágico (DRGE) e o adenocarcinoma de esôfago (AE), com ênfase nos mecanismos patogênicos, diagnóstico e estratégias de tratamento. A inflamação crônica causada pelo refluxo ácido, especialmente em casos de esôfago de Barrett, foi identificada como um fator crítico na progressão para o adenocarcinoma. Além disso, a obesidade surge como um fator de risco significativo, exacerbando os sintomas da DRGE e aumentando a predisposição ao desenvolvimento do AE. A modulação do microbioma oral e a dietoterapia são discutidas como abordagens terapêuticas emergentes e promissoras, embora necessitem de mais evidências para ampla adoção clínica. O uso de inibidores da bomba de prótons (IBPs) e o monitoramento endoscópico regular são apresentados como estratégias fundamentais para o controle da DRGE e a detecção precoce de lesões pré-malignas. Este estudo conclui que a prevenção e o tratamento do AE em pacientes com DRGE requerem uma abordagem multidisciplinar e personalizada, combinando mudanças no estilo de vida, monitoramento clínico rigoroso e intervenções terapêuticas adequadas.

10.36557/2674-8169.2024v6n8p4742-4757

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PO-0130 Campylobacter Gastroenteritis In Children

Archives of Disease in Childhood (2014)

K Oliveira Benedita Bianchi de Aguiar I Nunes Adriana Pedrosa Hilda Costa

Introduction

Acute gastroenteritis (AGE) remains, throughout Europe, a public health issue. Campylobacter is the most common enteropathogen after the age of five, particularly in Northern Europe.

Objective

Epidemiological data of the paediatric population with AGE by Campylobacter.

Methods

Retrospective data collection from clinical records of patients less than 18 years with confirmed Campylobacter positive stool cultures over a one year period.

Results

Out of 322 patients with AGE and at least one or more clinical criteria for stool culture (fever, blood or mucus stools in our case), in 83 (25.8%) Campylobacter was isolated. Although, this was the most frequently identified agent, there was, an inverse relationship with increasing age (mean age 2.8 years; range 3 weeks to 17 years). Most cases (39.8%) occurred in the spring. Serotypes isolated were C. jejuni in 83.1% and C. coli in 3.6%. Possible food items responsible included free range home produced eggs and non-potable water. In 12% there was a family history of illness and in one patient theres was a previous infection by Campylobacter. Eleven (13.3%) children required admission. Antibiotics were started prior to stool culture results in only two cases; following the stool cultures only one child was given antibiotics, having the remaining 98.8% clinically improved by then.

Discussion

AGE is a self-limited disease with most patients recovering within a weak. Rehydration and electrolyte correction is the mainstay of treatment.

10.1136/archdischild-2014-307384.794

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PO-0131 Value Of Stool Culture Of Children

Archives of Disease in Childhood (2014)

K Oliveira Benedita Bianchi de Aguiar I Nunes Ãngela Afonso Fernanda de Paula Ciribelli da Silva

Introduction

Acute gastroenteritis (AGE) remains, throughout Europe, a public health issue. Under the age of 5, some 20 to 30% of bacterial microorganisms are identified. However, cost-effectiveness of routine stool cultures yielding only 2% results preclude routine stool culturing.

Objective

Evaluation of the value of stool culture of children with AGE.

Methods

Retrospective data collection from clinical records of patients less than 18 years old submitted to stool cultures over a one year period.

Results

Out of 322 stool culture, 56.8% fulfilled the accepted ESPGHAN criteria and 74.8% had at least 1 clinical predictor of positivity (fever, blood or mucus stools, > 10 bowel actions/24 h, abdominal pain, travelling to highly epidemic countries). There were 121 positive cultures positive, 79.3% in patients obeying the defined criteria and 91.7% with clinical predictors of positivity. Campylobacter was the most frequently identified agent (68.6%), followed by Salmonella. Campylobacter decreased within an increasing age whilst Salmonella showed an inverse pattern. Campylobacter was the most frequently identified agent throughout all seasons of the year, followed by Salmonella, except in the winter when Yersinia took the second place.

Discussion

Sticking to accepted criteria for stool collection and/or to defined clinical features, increasing the yield of stool cultures.

10.1136/archdischild-2014-307384.795

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Assessment of pathological response of breast cancer in patients undergoing neoadjuvant chemotherapy in a refferal hospital in Amazonas State

Mastology (2024)

Kaiom Cesar Xavier Pacheco Guilherme Vieira Pereira Heitor Augusto de Magalhães e Silva Henrique Vieira Pereira Júlia Neves Becil

Introduction: The therapeutic options for breast cancer are diverse. Increasingly, treatments are established on an individual basis, depending on a series of variables ranging from age to the molecular profile of the tumor. When neoadjuvant chemotherapy (NAC) is necessary, adequate clinical evaluation (CE) and control examinations, such as breast ultrasound (US) and mammography (MMG), are of fundamental importance, as it is necessary to reevaluate the tumor lesion to determine an individualized surgical treatment, with the aim of performing breast-conserving surgery within the available techniques. This study sought to evaluate the pathological response of patients undergoing neoadjuvant chemotherapy, analyzing the presence or absence of tumor reduction by relating the physical examination with imaging methods (MMG and US), taking the anatomopathological examination measurements as the gold standard, thus intending to identify the best method for evaluating the pathological response. Methods: This was a prospective, observational, analytical cohort study. The study included 41 patients diagnosed with breast cancer detected by mammography and ultrasound (MMG and US) followed by biopsy, who underwent neoadjuvant chemotherapy (NAC) and surgery. The measurements of the malignant breast lesions obtained by CE, MMG and US were compared with the anatomopathological measurements on biopsy as the gold standard. Results: Pearson's correlation coefficient was the statistical method used for evaluation, finding a value of 0.49 between the anatomopathological examination and CE, 0.47 between the anatomopathological examination and MMG and 0.48 between the anatomopathological examination and US (p<0.05). Conclusions: CE, MMG and US showed a moderate correlation with anatomopathological measurement, in addition to a moderate correlation between them, demonstrating equivalence in the pre-surgical definition of the size of the breast tumor after NAC, being complementary to each other to define a measure of greater accuracy of the tumor in breast cancer.

Neoadjuvant Therapy

10.29289/2594539420230002

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Pulsed Field Ablation for Atrial Fibrillation With Persistent Left Superior Vena Cava and Heterotaxy Syndrome

JACC. Clinical electrophysiology (2025)

Jorge Romero Andrés F. Miranda‐Arboleda Mohamed Gabr K Oliveira William H. Sauer

Heterotaxy

10.1016/j.jacep.2024.10.032

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