Louise S. Acheson

Airedale NHS Foundation Trust

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Georgia L. Wiesner

Vanderbilt University Medical Center

Wendy S. Rubinstein

National Cancer Institute

Mack T. Ruffin

Penn State Milton S. Hershey Medical Center

Catharine Wang

Guangxi Medical University

Suzanne M. O’Neill

Northwestern University

James V. Davis

Kaiser Permanente Center for Health Research

Susan K. Peterson

The University of Texas MD Anderson Cancer Center

Kristin R. Muessig

Kaiser Permanente Center for Health Research

Katrina A.B. Goddard

Kaiser Permanente Center for Health Research

Sapna Syngal

Brigham and Women's Hospital

Cooperative Institutions

Case Western Reserve University

University of East Anglia

Kaiser Permanente Center for Health Research

University School

Kaiser Permanente

University Hospitals of Cleveland

National Institutes of Health

University of Washington

University of Michigan–Ann Arbor

University of Colorado Denver

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Association of common genetic variants in SMAD7 and risk of colon cancer

Carcinogenesis (2009)

Cheryl L. Thompson Sarah J. Plummer Louise S. Acheson T. C. Tucker Graham Casey

Two recent genome-wide association studies (GWAS) identified three common variants in SMAD7 (rs4464148, rs4939827 and rs12953717) that confer modest susceptibility to colorectal cancer. Here, we replicated the association of rs4464148 with colon cancer in a population-based case–control study (561 cases and 721 controls). Compared with the TT genotype, those with CT and CC had an adjusted odds ratio (OR) and 95% confidence interval of 1.06 (0.82–1.38) and 1.86 (1.17–2.96), respectively ( Ptrend = 0.04). However, stratified analyses revealed that this association was limited to women only [OR = 1.25 (0.88–1.78) for CT and OR = 2.76 (1.53–4.98) for CC, Ptrend = 0.002, Pinteraction = 0.08], which was not noted in any GWAS. Similarly, we found evidence for association with both rs4939827 and rs12953717 in women only ( P = 0.007 in dominant rs4939827 model and P = 0.015 in recessive rs12953717 model), but not in men ( P > 0.05) and evidence of an interaction with gender ( P = 0.015 for rs4939827 and P = 0.061 for rs12953717). Similar effect modification was found in haplotype analyses. Our data add evidence supporting these genetic variants as markers predisposing to colon cancer, specifically in women.

Genome-wide Association Study

Genetic Association

Genetic predisposition

10.1093/carcin/bgp086

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Citations (50)

Clinical utility of family history for cancer screening and referral in primary care: A report from the Family Healthware Impact Trial

Genetics in Medicine (2011)

Wendy S. Rubinstein Louise S. Acheson Suzanne M. O’Neill Mack T. Ruffin Catharine Wang

Cancer screening

Cancer Prevention

10.1097/gim.0b013e3182241d88

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Citations (82)

Family history-taking in community family practice: Implications for genetic screening

Genetics in Medicine (2000)

Louise S. Acheson Georgia L. Wiesner Stephen J. Zyzanski Meredith A. Goodwin Kurt C. Stange

Medical History

Medical record

Family doctors

10.1097/00125817-200005000-00004

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Citations (232)

Comparison of three prenatal risk scores in a series of low-risk pregnancies.

PubMed (1988)

Rod Kelly Louise S. Acheson S J Zyzanski

Three prepartum obstetrical risk-scoring methods (Goodwin, Halliday, Hobel) were retrospectively applied to a consecutive series of 795 singleton pregnancies. The study population was low risk overall, with a perinatal mortality rate of 11 per 1000 and a primary cesarean section rate of 9.7%. The predictive ability of the scores was tested for individual outcomes as well as for a "combined measure" designed to group outcomes of clinical interest. Outcome variables examined included labor arrests, need for augmentation of labor, fetal heartrate abnormalities during labor, selection of or transfer to a more intensive level of care, indicated forceps delivery, cesarean section, resuscitation, Apgar scores, permanent injury, and perinatal deaths. Along with expected differences in sensitivity and specificity, there were differences among the three scores in performance as measured by positive and negative predictive value. Goodwin's system performed somewhat better overall. All three systems performed better in multiparous than in primiparous patients, but primiparas experienced more adverse outcomes.

Singleton

Apgar score

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Citations (6)

Pregnancy and childbirth among the amish

Social Science & Medicine (1993)

Karla Campanella Jill E. Korbin Louise S. Acheson

Prenatal Care

10.1016/0277-9536(93)90017-x

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Citations (27)

Components of family history associated with women's disease perceptions for cancer: A report from the Family Healthware™ Impact Trial

Genetics in Medicine (2010)

Wendy S. Rubinstein Suzanne M. O’Neill Nan Rothrock Erin J. Starzyk Jennifer L. Beaumont

To determine the specific components of family history and personal characteristics related to disease perceptions about breast, colon, and ovarian cancers.

Worry

Risk Perception

10.1097/gim.0b013e3181fbe485

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Citations (18)

Contents

Diabetes Research and Clinical Practice (2012)

Alexander Nagrebetsky Simon J Griffi A Kinmonth Steven K. Sutton Anthea Craven

10.1016/s0168-8227(12)00146-5

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Citations (0)

Identifying and Testing for Hereditary Susceptibility to Common Cancers

CA A Cancer Journal for Clinicians (2004)

Randa Sifri S. Gangadharappa Louise S. Acheson

Hereditary cancer syndromes account for an estimated 5% of breast, ovarian, and colon cancers. The rapid discovery of cancer-related genes in the last 15 years has propelled the field of cancer genetic risk assessment forward. With patients becoming increasingly aware of available genetic testing options, it is important that various health professionals become knowledgeable in identifying and advising patients at increased risk for a hereditary cancer syndrome. This article will outline the components of providing a hereditary cancer risk assessment with a focus on hereditary breast and ovarian cancer syndrome and hereditary colon cancer.

Hereditary Cancer

Lynch Syndrome

Hereditary Diseases

10.3322/canjclin.54.6.309

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Citations (55)

Focus on the family, Part I: What is your family focus style?

PubMed (2001)

Robin S. Gotler Jack H. Medalie Stephen J. Zyzanski George E. Kikano Louise S. Acheson

The article, part of a series based on research from the Direct Observation of Primary Care Study, will explore how prevalent a is in family practice and how that focus can affect patient outcomes.

Affect

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Citations (3)

Fostering applications of genetics in primary care: What will it take?

Genetics in Medicine (2003)

Louise S. Acheson

Medical genetics

Primary (astronomy)

Cancer genetics

10.1097/01.gim.0000056946.67707.67

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Citations (21)