Bettina Rosner

Robert Koch Institute

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Klaus Stark

Robert Koch Institute

Dirk Werber

Austrian Agency for Health and Food Safety

Helen Bernard

Centre Hospitalier Universitaire de Sherbrooke

Hendrik Wilking

Robert Koch Institute

Rita Prager

Robert Koch Institute

Anika Schielke

Robert Koch Institute

Antje Flieger

Robert Koch Institute

Christina Frank

Robert Koch Institute

Michael Höhle

Robert Koch Institute

Luise Müller

Statens Serum Institut

Cooperative Institutions

HealthPartners

Public Health Laboratory

Robert Koch Institute

Federal Institute for Risk Assessment

European Centre for Disease Prevention and Control

Harvard University

Freie Universität Berlin

National Institute for Public Health and the Environment

Charité - Universitätsmedizin Berlin

Federal Office of Consumer Protection and Food Safety

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The genetics of the Alport syndrome.

PubMed (1974)

Tishler Pv Bettina Rosner

Analysis of the age at death of males with the Alport syndrome points out two distinct populations: one in which males die between ages 16 and 28 years, and the other in which males die between ages 33.5 and 52.2 years. Evidence suggests that these result from different genes of large effect. The segregation ratios of children of parents with Alport syndrome of either variety are generally consistent with an autosomal dominant mode of transmission, but the anomalous segregation from affected fathers remains to be explained.

Alport syndrome

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Citations (25)

Backtracking and forward checking of human listeriosis clusters identified a multiclonal outbreak linked to Listeria monocytogenes in meat products of a single producer

Figshare (2023)

Stefanie Lüth Sven Halbedel Bettina Rosner Hendrik Wilking Alexandra Holzer

Due to its high case fatality rate, foodborne listeriosis is considered a major public health concern worldwide. We describe one of the largest listeriosis outbreaks in Germany with 83 cases of invasive listeriosis between 2013 and 2018. As part of the outbreak investigation, we identified a highly diverse Listeria monocytogenes population at a single producer of ready-to-eat meat products. Strikingly, the extensive sampling after identification of a first match between a cluster of clinical isolates and a food isolate allowed for a linkage between this producer and a second, previously unmatched cluster of clinical isolates. Bacterial persistence in the processing plant and indications of cross-contamination events explained long-term contamination of food that led to the protracted outbreak. Based on screening for virulence factors, a pathogenic phenotype could not be ruled out for other strains circulating in the plant, suggesting that the outbreak could have been even larger. As most isolates were sensitive to common biocides used in the plant, hard to clean niches in the production line may have played a major role in the consolidation of the contamination. Our study demonstrates how important it is to search for the origin of infection when cases of illness have occurred (backtracking), but also clearly highlights that it is equally important to check whether a contamination at food or production level has caused disease (forward checking). Only through this two-sided control strategy, foodborne disease outbreaks such as listeriosis can be minimized, which could be a real improvement for public health.

Backtracking

10.6084/m9.figshare.12853694

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Ergebnisbericht der Task Force EHEC zur Aufklärung des EHEC O104:H4 Krankheitsausbruchs in Deutschland

Journal of Consumer Protection and Food Safety (2011)

Helen Bernard Martin Bisping Bernd Broschewitz Michael Bucher Alexandra Fetsch

Task force

10.1007/s00003-011-0710-7

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Citations (9)

Clinical aspects and self-reported symptoms of sequelae of Yersinia enterocolitica infections in a population-based study, Germany 2009–2010

BMC Infectious Diseases (2013)

Bettina Rosner Dirk Werber Michael Höhle Klaus Stark

Foodborne Yersinia enterocolitica infections continue to be a public health problem in many countries. Consumption of raw or undercooked pork is the main risk factor for yersiniosis in Germany. Small children are most frequently affected by yersiniosis. In older children and young adults, symptoms of disease may resemble those of appendicitis and may lead to hospitalization and potentially unnecessary appendectomies. Y. enterocolitica infections may also cause sequelae such as reactive arthritis (ReA), erythema nodosum (EN), and conjunctivitis. We studied clinical aspects of yersiniosis, antimicrobial use, and self-reported occurrence of appendectomies, reactive arthritis, erythema nodosum and conjunctivitis. To assess post-infectious sequelae participants of a large population-based case–control study on laboratory-confirmed Y. enterocolitica infections conducted in Germany in 2009–2010 were followed for 4 weeks. Diarrhea occurred most frequently in children ≤4 years (95%); abdominal pain in the lower right quadrant was most common in children 5–14 years of age (63%). Twenty-seven per cent of patients were hospitalized, 37% were treated with antimicrobials. In 6% of yersiniosis patients ≥5 years of age, appendectomies were performed. Self-reported symptoms consistent with ReA were reported by 12% of yersiniosis patients compared to 5% in a reference group not exposed to yersiniosis. Symptoms consistent with EN were reported by 3% of yersiniosis patients compared to 0.1% in the reference group. Symptoms of conjunctivitis occurred with the same frequency in yersiniosis patients and the reference group. Acute Y. enterocolitica infections cause considerable burden of illness with symptoms lasting for about 10 days and hospitalizations in more than a quarter of patients. The proportion of yersiniosis patients treated with antimicrobial drugs appears to be relatively high despite guidelines recommending their use only in severe cases. Appendectomies and post-infectious complications (ReA and EN) are more frequently reported in yersiniosis patients than in the reference group suggesting that they can be attributed to infections with Y. enterocolitica. Physicians should keep recent Y. enterocolitica infection in mind in patients with symptoms resembling appendicitis as well as in patients with symptoms of unclear arthritis.

Yersiniosis

Yersinia enterocolitica

Reactive arthritis

Erythema Nodosum

10.1186/1471-2334-13-236

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Citations (59)

Recruiting controls from an online panel for a case-control study enabled a timely and reliable foodborne Salmonella outbreak investigation, Germany 2021

Zenodo (CERN European Organization for Nuclear Research) (2022)

A Luczynska Johannes Dreesman Elke Mertens Mareike Wollenweber Delphine Perriat

10.5281/zenodo.7333295

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Multinational collaboration in solving a European Salmonella Braenderup outbreak linked to imported melons, 2021

Eurosurveillance (2024)

Hannah Moore Martine G. Aabye Ann Hoban Bettina Rosner Stine Kjær Lefèvre

A genomic cluster of Salmonella Braenderup ST22, a serovar of Salmonella enterica subsp. enterica which causes symptoms of gastrointestinal illness, was notified by Danish authorities to the European Centre for Disease Prevention and Control (ECDC) on 3 May 2021. By 6 July 2021, S. Braenderup outbreak cases (n = 348) had been reported from 12 countries in the European Union/European Economic Area (EU/EEA) and the United Kingdom (UK), including 68 hospitalised cases. With support from affected EU/EEA countries, and in partnership with the European Food Safety Authority (EFSA), ECDC established an international outbreak investigation team to rapidly identify the source and prevent outbreak spread. Consumption information was shared with affected countries through a standard line list, revealing that 124 of 197 cases (63%) reported having eaten (any) melons within 7 days prior to disease onset. The speed and completeness of the investigation, which identified the outbreak vehicle as galia melons imported from Honduras in June 2021, was a direct result of extensive collaboration and information sharing between countries’ national food safety and public health authorities. This article describes the outbreak and the benefits, successes, and challenges of multi-country collaboration for consideration in future large foodborne outbreaks across Europe.

10.2807/1560-7917.es.2024.29.1.2300273

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Citations (2)

Einfluss von oralen Kontrazeptivaauf kardiovaskuläre Risikofaktorenbei 14- bis 17-jährigen Mädchen in Deutschland

Bettina Rosner

10.25646/5274

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Anaerobic metabolism of primary and secondary forms of Photorhabdus luminescens

FEMS Microbiology Letters (1996)

Bettina Rosner Jerald C. Ensign Bernhard Schink

An oxygen electrode inserted into a dead Manduca sexta larva infected with Heterorhabditis nematodes carrying the bacterium Photorhabdus luminescens showed barely detectable levels of oxygen in a 1 to 2 mm zone below the cuticle, and virtual anaerobiosis deeper in the carcass. This observation indicates that the bacteria in this habitat, where they are actively growing, are probably carrying out a fermentative metabolism. Therefore, the anaerobic metabolism of the primary and secondary form variants of P. luminescens Hm and NC1 was compared. Amino acids were not fermented by either strain, either singly or in mixtures. Glucose was fermented by both forms of both organisms, forming products typical of mixed acid fermentation by Enterobacteriaceae. The fermentation patterns were the same in the primary and secondary forms. Growth rates of the secondary form cells were higher in defined medium with glucose as energy and carbon source. Growth yields of the primary and secondary forms of strain Hm were nearly identical, whereas the growth yield of secondary form cells of strain NC1 was slightly higher than that of the primary form. The results of this study indicate that the observed predominance of primary form cells in infected insect larvae cannot be explained by an advantage over the secondary form cells related to the efficiency of anaerobic growth or fermentative metabolism.

Photorhabdus luminescens

Secondary metabolism

Photorhabdus

Strain (injury)

10.1111/j.1574-6968.1996.tb08341.x

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Citations (9)

Impact of climate change on foodborne infections and intoxications.

PubMed (2023)

Jessica Dietrich Jens A. Hammerl Annette Johne Oliver Kappenstein Christopher R. Loeffler

Temperature, precipitation, and humidity are important factors that can influence the spread, reproduction, and survival of pathogens. Climate change affects these factors, resulting in higher air and water temperatures, increased precipitation, or water scarcity. Climate change may thus have an increasing impact on many infectious diseases.The present review considers those foodborne pathogens and toxins in animal and plant foods that are most relevant in Germany, on the basis of a selective literature review: the bacterial pathogens of the genera Salmonella, Campylobacter and Vibrio, parasites of the genera Cryptosporidium and Giardia, and marine biotoxins.As climate change continues to progress, all infections and intoxications discussed here can be expected to increase in Germany.The expected increase in foodborne infections and intoxications presents a growing public health risk in Germany.

Waterborne diseases

Giardia

10.25646/11403

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Citations (25)

Does regular intake of salicylate influence mortality after 20 years? Swiss epidemiologic study 1968–87

Pain (1990)

U. C. Dubach Bettina Rosner Til Stürmer‎

The aim of this study was to examine whether mean data from categorical pain intensity and visual analogue scales for both pain intensity and relief could be used reliably to derive dichotomous outcome measures for meta-analysis. Individual patient data from randomised controlled trials of single-dose analgesics in acute postoperative pain were used. The methods used were as follows: data from 132 treatments with over 4700 patients were used to calculate mean %maxSPID (categorical pain intensity), %maxVAS-SPID (visual analogue pain intensity) and %maxVAS-TOTPAR (visual analogue pain relief); these were used to derive relationships with the number of patients who achieved at least 50% pain relief (%maxTOTPAR). Good agreement was obtained between the actual number of patients with >50%maxTOTPAR and the number calculated for all three measures. For SPID, verification included independent data sets. For calculations involving each measure, summing the positive and negative differences between actual and calculated numbers of patients with >50%maxTOTPAR gave an average difference of less than 0.25 patients per treatment arm. Reports of randomised trials of analgesics frequently describe results of studies in the form of mean derived indices, rather than using discontinuous events, such as number or proportion of patients obtaining at least 50% pain relief. Because mean data inadequately describe information with a non-normal distribution, combining such mean data in systematic reviews may compromise the results. Showing that dichotomous data can reliably be derived from mean SPID, VAS-SPID and VAS-TOTPAR as well as TOTPAR data in previously published acute pain studies makes much more information accessible for meta-analysis.

Categorical variable

Intensity

10.1016/0304-3959(90)92453-w

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