José Vivancos

Universidad Autónoma de Madrid

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Co-Authors

J. Egido

Hospital Clínico San Carlos

Jaime Masjuán

Instituto Ramón y Cajal de Investigación Sanitaria

ÁX

Álvaro Ximénez‐Carrillo

Hospital Universitario de La Princesa

Exuperio Díez–Tejedor

Universidad Autónoma de Madrid

José Castillo

Instituto de Investigación Sanitaria de Santiago

Joaquı́n Serena

Institut d'Investigació Biomèdica de Girona

Blanca Fuentes

Universidad Autónoma de Madrid

María Alonso de Leciñana

Universidad Autónoma de Madrid

Gustavo Zapata-Wainberg

Universidad Autónoma de Madrid

Sonia Quintas

Hospital Universitario de La Princesa

Cooperative Institutions

Inserm

306

Hospital Universitario de La Princesa

207

University College London

167

Centre National de la Recherche Scientifique

157

Universidad Autónoma de Madrid

151

Universitat Autònoma de Barcelona

150

Istituti di Ricovero e Cura a Carattere Scientifico

148

Assistance Publique – Hôpitaux de Paris

144

Sorbonne Université

138

Instituto de Salud Carlos III

137

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Underlying Causes of TIA and Minor Ischemic Stroke and Risk of Major Vascular Events

JAMA Neurology (2023)

Philippa C. Lavallée Hubert Charles Gregory W. Albers Louis R. Caplan Geoffrey A. Donnan

The coexistence of underlying causes in patients with transient ischemic attack (TIA) or minor ischemic stroke as well as their associated 5-year risks are not well known.

Stroke

10.1001/jamaneurol.2023.3344

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Citations (5)

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

Stroke (2013)

María Isabel Cuartero Iván Ballesteros Ana Moraga Florentino Nombela José Vivancos

Background and Purpose— Neutrophils have been traditionally recognized as major mediators of a deleterious inflammatory response in acute ischemic stroke, but their potential as a therapeutic target remains unexplored. Recent evidence indicates that neutrophils may acquire different phenotypes and contribute to resolution of inflammation through the release of anti-inflammatory mediators. Thus, similar to M2 macrophages, neutrophils have been proposed to shift toward an N2 phenotype, a polarization that is peroxisome proliferator-activated receptor-γ dependent in macrophages. We hypothesize that peroxisome proliferator-activated receptor-γ activation with rosiglitazone induces changes in neutrophilic mobilization and phenotype that might influence stroke outcome. Methods— Brain sections and cell suspensions were prepared from mice exposed to permanent distal middle cerebral artery occlusion. Double immunostaining with stereological counting of brain sections and flow-cytometry analysis of brain cell suspensions were performed. Results— Rosiglitazone accelerated neutrophil infiltration to the ischemic core, concomitantly to neuroprotection. Some neutrophils (≈31%) expressed M2 markers, namely Ym1 and CD206 (mannose receptor). After treatment with the peroxisome proliferator-activated receptor-γ agonist rosiglitazone, most neutrophils (≈77%) acquired an N2 phenotype. Interestingly, rosiglitazone increased neutrophil engulfment by microglia/macrophages, a clearance that preferentially affected the N2 subset. Conclusions— We present the first evidence of neutrophil reprogramming toward an N2 phenotype in brain inflammation, which can be modulated by activation of the peroxisome proliferator-activated receptor-γ nuclear receptor. We also show that N2 polarization is associated with an increased neutrophil clearance, thus suggesting that this switch is a crucial event for resolution of inflammation that may participate in neuroprotection.

Stroke

10.1161/strokeaha.113.002470

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Citations (303)

Neuroradiological worsening of brain abscess after adalimumab and methotrexate withdrawal: Do not forget Immune Reconstitution Inflammatory Syndrome

Journal of Clinical Neuroscience (2019)

Sonia Quintas Pedro Sánchez Manuel Carlos López José Vivancos

Brain abscess

10.1016/j.jocn.2018.12.018

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Citations (1)

In‐hospital stroke: a multi‐centre prospective registry

European Journal of Neurology (2010)

Rocío Vera Aída Lago Blanca Fuentes J. Gállego J. Tejada

in-hospital strokes (IHS) are relatively frequent. Avoidable delays in neurological assessment have been demonstrated. We study the clinical characteristics, neurological care and mortality of IHS.multi-centre 1-year prospective study of IHS in 13 hospitals. Demographic and clinical characteristics, admission diagnosis, quality of care, thrombolytic therapy and mortality were recorded.we included 273 IHS patients [156 men; 210 ischaemic strokes (IS), 37 transient ischaemic attacks (TIA) and 26 cerebral haemorrhages]. Mean age was 72 ± 12 years. Cardiac sources of embolism were present in 138 (50.5%), withdrawal of antithrombotic drugs in 77 (28%) and active cancers in 35 (12.8%). Cardioembolic stroke was the most common subtype of IS (50%). Reasons for admission were programmed or urgent surgery in 70 (25%), cardiac diseases in 50 (18%), TIA or stroke in 30 (11%) and other medical illnesses in 71 (26%). Fifty-two per cent of patients were evaluated by a neurologist within 3 h of stroke onset. Thirty-three patients received treatment with tPA (15.7%). Thirty-one patients (14.7%) could not be treated because of a delay in contacting the neurologist. During hospitalization, 50 patients (18.4%) died, 41 of them because of the stroke or its complications.cardioembolic IS was the most frequent subtype of stroke. Cardiac sources of embolism, active cancers and withdrawal of antithrombotic drugs constituted special risk factors for IHS. A significant proportion of patients were treated with thrombolysis. However, delays in contacting the neurologist excluded a similar proportion of patients from treatment. IHS mortality was high, mostly because of stroke.

Stroke

Fibrinolytic agent

10.1111/j.1468-1331.2010.03105.x

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Citations (62)

Endovascular treatment in acute ischaemic stroke. A Stroke Care Plan for the Region of Madrid

Neurología (English Edition) (2013)

María Alonso de Leciñana Jaime Díaz‐Guzmán J. Egido Ana García Patricia Martínez‐Sánchez

Ischaemic stroke

Stroke

Acute stroke

10.1016/j.nrleng.2013.09.005

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Citations (12)

A reversible severe gait disorder

Neurology (2016)

Gustavo Zapata-Wainberg Rocío López Ruiz Elena Fernández González Pilar Alcántara-Miranda Mercedes Gallego

A 53-year-old man was admitted for a 6-month progressive disabling gait disorder, weight loss, and increasing fatigue. Examination revealed a markedly impaired gait and flexion contractures of hips and knees, with limited extension (video 1 at [Neurology.org][1]). EMG and whole neuraxis MRI were normal. Laboratory workup proved primary adrenal insufficiency (AI) (serum cortisol 2.4 μg/dL, ACTH 513.8 pg/mL). Flexion contractures of the lower limbs1,2 (FCLL) due to AI was suspected. Prompt treatment with hydrocortisone supplementation led to a substantial clinical improvement (video 2). FCLL is a well-known but infrequent sign of AI. Prompt identification and treatment may reverse this disorder. [1]: http://neurology.org/lookup/doi/10.1212/WNL.0000000000003190

Muscle contracture

10.1212/wnl.0000000000003190

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Citations (0)

Leucoencefalopatía multifocal progresiva en paciente con lupus eritematoso sistémico: ¿podría ser la linfocitopenia-CD4+ el principal factor de riesgo?

Neurología (2019)

Laura Casado‐Fernández C. Rubio Hervás Sonia Quintas José Vivancos

10.1016/j.nrl.2019.11.001

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Citations (0)

Supplementary Material for: Epidemiology of Intracranial Haemorrhages Associated with Vitamin K Antagonist Oral Anticoagulants in Spain: TAC Registry

Gustavo Zapata-Wainberg Álvaro Ximénez‐Carrillo Lorena Benavente Jaime Masjuán Jaime Gállego Culleré

Vitamin K antagonist

10.6084/m9.figshare.4123077.v1

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Citations (0)

Inflammatory amyloid angiopathy: a series of clinical cases and a review of the literature (2507)

Neurology (2021)

Alicia González-Martínez Santiago Trillo-Senín Juan de la Vega Javier Villacieros Carmen Ramos

We present a series of probable AAIs based on clinical-radiological criteria treated in a tertiary spanish hospital.

Amyloid (mycology)

10.1212/wnl.96.15_supplement.2507

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Headache History-Taking in an Emergency Department: Impact Evaluation of a Training Session

Pain Medicine (2020)

Carlos Hervás Alba Somovilla Ana Beatriz Gago‐Veiga Jaime Alonso Carmen del Arco

Abstract Introduction Headache represents about 25% of the total neurological consultations at the emergency department (ED). Up to 80% of these consultations are represented by primary headaches, in which an accurate and directed history-taking may help reach the specific diagnosis avoiding unnecessary complementary tests and reducing diagnostic latencies. Methods We carried out a training session on headache management at the ED, focusing on history-taking and primary headaches’ diagnoses and management. We retrospectively compared the number of variables included in the medical reports and the percentage of patients who were diagnosed and/or treated for a primary headache between two months before and two months after the training session. Results A total of 369 medical histories were analyzed for this study (196 before and 173 after the training session). The number of essential variables regarding pain characteristics included in the medical reports showed a post-intervention increment from 4.34 ± 1.224 to 4.67 ± 1.079 (P = .007) and the number of total items registered also increased from 6.87 ± 1.982 to 7.53 ± 1.686 (P = 0.001). The percentage of patients that were given a specific diagnosis for primary headache showed an increment of 11.8% (P = .002) in the post-intervention group. Conclusion Educational interventions can improve history-taking in headache patients in the ED. This fact grants them as potential efficient measures to optimize patient management at Emergency Room.

Medical History

Primary headache

Past medical history

10.1093/pm/pnaa483

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Citations (0)