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Н. Ф. Тимченко

Central Research Institute of Epidemiology

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L Somova

Central Research Institute of Epidemiology

Svetlana A. Ermolaeva

Gamalei Institute of Epidemiology and Microbiology

Е. К. Псарева

Gamalei Institute of Epidemiology and Microbiology

Ruslan Adgamov

Ministry of Health of the Russian Federation

Л. С. Долматова

V.I. Il'ichev Pacific Oceanological Institute

О. А. Уланова

V.I. Il'ichev Pacific Oceanological Institute

Е. И. Дробот

Central Research Institute of Epidemiology

B. G. Andryukov

Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

E. P. Nedashkovskaya

Russian Academy of Sciences

Е П Недашковская

Cooperative Institutions

Russian Academy of Sciences

Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences

Far Eastern Federal University

Far Eastern Branch of the Russian Academy of Sciences

Academy of Medical Sciences

Central Research Institute of Epidemiology

Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences

Vladivostok State Medical University

Ministry of Health of the Russian Federation

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Generation of reactive oxygen species in different fractions of the coelomocytes of holothurianEupentacta fraudatrix in response to the thermostable toxin ofYersinia pseudotuberculosis in vitro

Chinese Journal of Oceanology and Limnology (2003)

Л. С. Долматова M. G. Eliseykina Н. Ф. Тимченко А. Л. Ковалева О. А. Шиткова

Incubation period

10.1007/bf02860423

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Citations (19)

STUDY OF PATHOGENICITY FACTORS OF YERSINIA PSEUDOTUBERCULOSIS STRAINS ISOLATED FROM MAMMALS

N. V. Rybkina Е. К. Псарева Н. Ф. Тимченко

Yersinia pseudotuberculosis

10.36233/978-5-9900432-9-9-67

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The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis

Molecular Genetics Microbiology and Virology (2019)

Н. Ф. Тимченко Е. К. Псарева Svetlana A. Ermolaeva

Yersinia pseudotuberculosis

Thermolabile

10.3103/s0891416819040104

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Effect of Thermolabile Toxin from Yersinia pseudotuberculosis on Functions of Innate Immunity Cells

Bulletin of Experimental Biology and Medicine (2014)

Н. Г. Плехова Е. И. Дробот Н. Ф. Тимченко L Somova E. V. Persiyanova

Thermolabile

Yersinia pseudotuberculosis

Yersinia

10.1007/s10517-014-2597-7

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Citations (1)

Nonenzymatic test system for noninstrumental determination of antibodies to species-specific fibers of Yersinia pseudotuberculosis on the basis of nanosized carbon particles

Doklady Biochemistry and Biophysics (2013)

Mikhail Rayev Н. Ф. Тимченко М. С. Бочкова E. P. Nedashkovskaya B. G. Andrukov

Yersinia pseudotuberculosis

Yersinia

10.1134/s1607672913040169

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Pathomorphological characteristics of experimental toxemia induced by thermostableYersinia pseudotuberculosis toxin

Bulletin of Experimental Biology and Medicine (2000)

L. M. Isachkova Н. Ф. Тимченко E. P. Nedashkovskaya S. D. Raznik

10.1007/bf02688197

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Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of Yersinia pseudotuberculosis Infection in Russia

Pathogens (2020)

L Somova F. F. Antonenko Н. Ф. Тимченко I. N. Lyapun

Pseudotuberculosis in humans until the 1950s was found in different countries of the world as a rare sporadic disease that occurred in the form of acute appendicitis and mesenteric lymphadenitis. In Russia and Japan, the Yersinia pseudotuberculosis (Y. pseudotuberculosis) infection often causes outbreaks of the disease with serious systemic inflammatory symptoms, and this variant of the disease has been known since 1959 as Far Eastern Scarlet-like Fever (FESLF). Russian researchers have proven that the FESLF pathogen is associated with a concrete clonal line of Y. pseudotuberculosis, characterized by a specific plasmid profile (pVM82, pYV 48 MDa), sequence (2ST) and yadA gene allele (1st allele). This review summarized the most important achievements in the study of FESLF since its discovery in the Far East. It has been established that the FESLF causative agent is characterized by a unique phenomenon of psychrophilicity, which consists of its ability to reproduce in the environment with its biologically low and variable temperature (4-12 °C), at which the pathogen multiplies and accumulates while maintaining or increasing its virulence, which ensures the emergence and development of the epidemic process. The key genetic and biochemical mechanisms of Y. pseudotuberculosis adaptation to changing environmental conditions were characterized, and the morphological manifestations of the adaptive variability of these bacteria in different conditions of their habitat were revealed. The main features of the pathogenesis and morphogenesis of FESLF, including those associated with the Y. pseudotuberculosis toxigenicity, were presented. The pathogenetic value of the plasmid PVM82, found only in the FESLF pathogen, was shown.

Yersinia pseudotuberculosis

Scarlet fever

10.3390/pathogens9060436

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Yersinia pseudotuberculosis, Its Toxins and Plant Cells

Kluwer Academic Publishers eBooks (2006)

Н. Ф. Тимченко М. Г. Елисейкина Viktor Bulgakov Elena Bulakh Elena Yasnetskaya

Yersinia pseudotuberculosis

Plant cell

Yersinia

10.1007/0-306-48416-1_34

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Molecular and Genetic Characteristics of Cell Death in Prokaryotes

Molecular Genetics Microbiology and Virology (2018)

B. G. Andryukov L Somova Н. Ф. Тимченко

10.3103/s0891416818020039

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Термостабильный токсин бактерии Yersinia pseudotuberculosis дизрегулирует функциональную активность двух типов фагоцитов голотурии Eupentacta fraudatrix

Известия Российской академии наук Серия биологическая (2019)

Л. С. Долматова О. А. Уланова Н. Ф. Тимченко

Yersinia pseudotuberculosis

Yersinia

10.1134/s0002332919020048

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