Herberto José Chong‐Neto

Hospital de Clínicas Universidade Federal do Paraná

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Co-Authors

Nelson Augusto Rosário Filho

Universidade Federal do Paraná

148

Dirceu Solé

Universidade Federal de São Paulo

Carlos Antônio Riedi

Hospital de Clínicas Universidade Federal do Paraná

Marilyn Urrutia‐Pereira

Universidade Federal do Pampa

Débora Carla Chong‐Silva

Universidade Federal do Paraná

Cristine Secco Rosário

Universidade Federal do Paraná

Anete Sevciovic Grumach

Universidade de São Paulo

Solange Oliveira Rodrigues Valle

Hospital Universitário Clementino Fraga Filho

Faradiba Sarquis Serpa

Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória

Nelson Augusto Rosário

Universidade do Porto

Cooperative Institutions

Universidade Federal do Paraná

164

Universidade de São Paulo

136

Charité - Universitätsmedizin Berlin

128

University of Mississippi Medical Center

128

State Street (United States)

124

American College of Allergy, Asthma and Immunology

122

Universidade Federal de São Paulo

Humboldt-Universität zu Berlin

Associação Brasileira de Alergia e Imunologia

ENT and Allergy

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Pediatric allergy and immunology in Brazil

Pediatric Allergy and Immunology (2013)

Nelson Augusto Rosário Filho C.M.A. Jacob Dirceu Solé Antônio Condino‐Neto L. Karla Arruda

Abstract The subspecialty of pediatric allergy and immunology in B razil is in its early years and progressing steadily. This review highlights the research developed in the past years aiming to show the characteristics of allergic and immunologic diseases in this vast country. Epidemiologic studies demonstrated the high prevalence of asthma in infants, children, and adolescents. Mortality rates and average annual variation of asthma hospitalization have reduced in all pediatric age groups. Indoor aeroallergen exposure is excessively high and contributes to the high rates of allergy sensitization. Prevalence of food allergy has increased to epidemic levels. Foods (35%), insect stings (30%), and drugs (23%) are the main etiological agents of anaphylaxis in children and adolescents. Molecular diagnosis of primary immunodeficiencies ( PID ) showed a high incidence of fungal infections including paracoccidioidomycosis in X ‐linked hyper‐ I g M syndrome, and the occurrence of BCG adverse reactions or other mycobacterial infections in patients with chronic granulomatous disease. Education in pediatric allergy and immunology is deficient for medical students, but residency programs are effective in training internists and pediatricians for the practice of allergy. The field of PID requires further training. Last, this review is a tribute to P rof. D r. C harles N aspitz, one of the pioneers of our specialty in B razil.

Subspecialty

Atopy

Etiology

Aeroallergen

Clinical immunology

Egg allergy

10.1111/pai.12069

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Citations (16)

RAST, Inmunoblot, Inmunocap e ISAC en alergia alimentaria

Deleted Journal (2023)

Herberto José Chong‐Neto

Después del descubrimiento de la IgE, los avances tecnológicos han proporcionado nuevas herramientas de laboratorio para la cuantificación de anticuerpos IgE específicos de alérgenos en suero y en la superficie de basófilos-mastocitos. Las pruebas in vitro ofrecen numerosas ventajas: cuantificación precisa, falta de interferencia de fármacos, seguridad y almacenamiento a largo plazo de las muestras. Los inmunoensayos cuantitativos para anticuerpos IgE pueden ser un complemento de las pruebas cutáneas. El reactivo de alergeno en fase sólida (alergosorbente) o líquida es el componente principal del ensayo que confiere especificidad a la prueba de anticuerpos IgE. Es el reactivo más complejo y altamente variable en los ensayos de anticuerpos IgE. La elección de utilizar recombinantes de diagnóstico en una única plataforma en lugar de múltiples se realiza caso por caso (considerando el historial previo y el perfil clínico) y de manera dependiente de los alérgenos. Aunque la mayor parte de las alergias alimentarias se limitan a una pequeña cantidad de posibles desencadenantes, estos alimentos son muy complejos al momento de evaluar su potencial alergénico. La posibilidad de fraccionar el alérgeno y entender algunos de sus componentes como potencialmente importantes para definir el riesgo de reacción clínica, reactividad cruzada o persistencia de la alergia, abrió una nueva era en el campo de la alergia, denominada alergia molecular. La identificación del componente alergénico responsable de las reacciones supone una herramienta importante para confirmar la información y gravedad de los síntomas, historia natural de la enfermedad, posibilidad de reactividad cruzada y clínica (marcadores de alergia).

10.29262/ram.v70i4.1335

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Expanding the application of a standardized questionnaire on recurrent wheezing in infancy Expandindo a aplicação de questionário padronizado para sibilância recorrente no lactente

Herberto José Chong‐Neto Nelson Augusto Rosário Filho

Objective: To verify the possibility of extending the application of an instrument to investigate the prevalence and clinical characteristics of wheezing in infants. Methods: A cross-sectional study conducted as part of the International Study on Wheezing in Infants (EISL, Estudio Internacional de Sibilancias en Lactantes). A questionnaire was administered to parents of infants aged 12 to 15 months (group I) and 16 to 24 months (group II) infants. Results: One thousand, three hundred and sixty-four infants (45.4%) in group I and 250 (46.7%) in group II had had at least one episode (p = 0.58). The numbers of patients on inhaled β2-agonists, inhaled or oral steroids and/or leukotriene modifiers were similar in both groups (p = 0.52, 0.12, 0.06, and 0.75). There were no differences between the groups in terms of night-time symptoms, shortness of breath, emergency room visits, asthma hospitalization or asthma diagnosed by a doctor (p = 0.09, 0.28, 0.54, and 0.45). Conclusion: The application of the questionnaire can be extended to include infants up to 24 months of age.

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Latin American Guideline on the Diagnosis and Treatment of Ocular Allergy - On behalf of the Latin American Society of Allergy, Asthma and Immunology (SLAAI)

Arquivos de Asmas Alergia e Imunologia (2022)

Herberto José Chong‐Neto Alfonso Cepeda Ana Sofia Moreira Andrea Leonardi Cristine S. Rosário

A alergia ocular, também conhecida como conjuntivite alérgica (CA), é uma reação de hipersensibilidade mediada por imunoglobulina E (IgE) do olho desencadeada por aeroalérgenos, principalmente ácaros da poeira doméstica e pólen de gramíneas.Os sintomas geralmente consistem em prurido ocular ou periocular, lacrimejamento e olhos vermelhos que podem estar presentes durante todo o ano ou sazonalmente.A alergia ocular tem frequência elevada, é subdiagnosticada e pode ser debilitante para o paciente.É potencialmente danosa para a visão, nos casos em que ocasiona cicatrização corneana grave, e na maioria dos pacientes associa-se a outros quadros alérgicos, principalmente rinite, asma e dermatite atópica.É classificada em conjuntivite alérgica perene, conjuntivite alérgica sazonal, ceratoconjuntivite atópica e ceratoconjuntivite vernal.O diagnóstico procura evidenciar o agente etiológico e a confirmação se dá pela realização do teste de provocação conjuntival.O tratamento baseia-se em evitar o contato com os desencadeantes, lubrificação, anti-histamínicos tópicos, estabilizadores de mastócitos, imunossupressores e imunoterapia específica com o objetivo de obter o controle e prevenir as

Guideline

10.5935/2526-5393.20220002

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Citations (1)

Fatal and Unresponsive Cytomegalovirus Infection in a New Homozygous FOXN1 Gene Variation Causing Nude SCID

Journal of Clinical Immunology (2022)

Herberto José Chong‐Neto Gesmar Rodrigues Silva Segundo Nelson Augusto Rosário Filho Carlos Antônio Riedi Débora Carla Chong‐Silva

Medical microbiology

Cytomegalovirus

10.1007/s10875-021-01192-3

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Citations (1)

Relatório sobre o controle do tabagismo nas Américas: qual é a realidade no Brasil?

Brazilian Journal of Allergy and Immunology (BJAI) (2019)

Marilyn Urrutia‐Pereira Herberto José Chong‐Neto Dirceu Solé

10.5935/2526-5393.20190037

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Phadiatop, Phadiatop Infant and total IgE evaluated in allergic Brazilian children and adolescents

Allergologia et Immunopathologia (2019)

Felipe Faria Pierotti Carolina Sánchez Aranda Renata Rodrigues Cocco Emanuel Sarinho Flávio Sano

Concordance

Anamnesis

Population study

10.1016/j.aller.2019.06.013

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Citations (3)

Síndrome de Enterocolite Induzida por Proteína Alimentar (FPIES): um novo diagnóstico diferencial para alergia alimentar

Brazilian Journal of Allergy and Immunology (BJAI) (2019)

Yara Henrique Martins Costa Lúcia Gutheil-Gonçalves Denise Tiemi-Miyakawa Cristine Secco Rosário Débora Carla Chong‐Silva

10.5935/2526-5393.20190036

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Homozygous Splice ADA2 Gene Mutation Causing ADA-2 Deficiency

Journal of Clinical Immunology (2019)

Herberto José Chong‐Neto Gesmar Rodrigues Silva Segundo Márcia Bandeira Débora Carla Chong‐Silva Cristine Secco Rosário

Medical microbiology

splice

Splice site mutation

10.1007/s10875-019-00697-2

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Citations (11)

Association between exposure to pesticides and allergic diseases in children and adolescents: a systematic review with meta-analysis

Jornal de Pediatria (2022)

Marina de Barros Rodrigues Denise Siqueira de Carvalho Débora Carla Chong‐Silva Marilyn Urrutia‐Pereira Guilherme Souza Cavalcanti de Albuquerque

The study aimed to conduct a systematic review of the literature to verify the association between exposure to pesticides and allergic diseases (asthma, allergic rhinitis, and atopic dermatitis) in children and adolescents.

10.1016/j.jped.2021.10.007

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Citations (25)