Aiguo Ni

University of North Texas

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i-10 index

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Co-Authors

Sai H. Chavala

University of North Texas

Victor J. Dzau

Duke Medical Center

Husheng Yan

Nankai University

Ming Jing Wu

Air Force Engineering University

Lee Chao

Medical University of South Carolina

Julie Chao

Medical University of South Carolina

Julie Chao

Medical University of South Carolina

Arjun Deb

University of California, Los Angeles

Binglin He

ShanghaiTech University

Biraj Mahato

University of Southern California

Cooperative Institutions

University of North Texas

University of North Texas Health Science Center

Duke Medical Center

Medical University of South Carolina

Duke University

Duke University Hospital

University of North Carolina at Chapel Hill

Tianjin Medical University

Capital Medical University

Huazhong University of Science and Technology

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Pharmacologic fibroblast reprogramming into photoreceptors restores vision

Nature (2020)

Biraj Mahato Koray Dogan Kaya Yan Fan Nathalie Sumien Ritu A. Shetty

Reprogramming

10.1038/s41586-020-2201-4

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Citations (89)

SFRP2 Regulates Cardiomyogenic Differentiation by Inhibiting a Positive Transcriptional Autofeedback Loop of Wnt3a

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2008)

Arjun Deb Bryce H. Davis Jian Guo Aiguo Ni Jing Huang

WNT3A

10.17615/jm55-rc70

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Citations (0)

Aggregation of a calmodulin-binding peptide

Kluwer Academic Publishers eBooks (2005)

Husheng Yan Xiaohui Cheng Aiguo Ni Binglin He

10.1007/0-306-46880-8_16

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Citations (0)

Synthesis of the fragments of melittin and their interaction with calmodulin

Liping Liu Husheng Yan Aiguo Ni Xiaohui Cheng Bing-Lin He

Four fragments of melittin were manually synthesized by standard solid-phase method: Mel 12, Mel 13, Mel 14 and Mel 15. Their interaction with calmodulin was studied by electrophoresis method, inhibited activity of Ca~(2+)-dependent 3^,5^-cAMP phosphodiesterase and flurescence technique. The results show that these peptides form 1:1 complex with calmodulin and inhibit the activity of phosphodiesterase. Among these peptides, Mel 14 and Mel 15 have almost the same binding activity with calmodulin as the intact peptide Melittin.

Melittin

Cyclic nucleotide phosphodiesterase

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Facile and Efficient Reprogramming of Ciliary Body Epithelial Cells into Induced Pluripotent Stem Cells

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2013)

Aiguo Ni Ming Jing Wu Yuka Nakanishi Sai H. Chavala

Reprogramming

10.17615/1khv-vy26

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Citations (1)

Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy

Circulation Research (2008)

Massimiliano Gnecchi Zhiping Zhang Aiguo Ni Victor J. Dzau

Animal and preliminary human studies of adult cell therapy following acute myocardial infarction have shown an overall improvement of cardiac function. Myocardial and vascular regeneration have been initially proposed as mechanisms of stem cell action. However, in many cases, the frequency of stem cell engraftment and the number of newly generated cardiomyocytes and vascular cells, either by transdifferentiation or cell fusion, appear too low to explain the significant cardiac improvement described. Accordingly, we and others have advanced an alternative hypothesis: the transplanted stem cells release soluble factors that, acting in a paracrine fashion, contribute to cardiac repair and regeneration. Indeed, cytokines and growth factors can induce cytoprotection and neovascularization. It has also been postulated that paracrine factors may mediate endogenous regeneration via activation of resident cardiac stem cells. Furthermore, cardiac remodeling, contractility, and metabolism may also be influenced in a paracrine fashion. This article reviews the potential paracrine mechanisms involved in adult stem cell signaling and therapy.

Stem Cell Therapy

Transdifferentiation

Cell therapy

10.1161/circresaha.108.176826

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Citations (1,923)

Abstract 707: Genetically Modified Mesenchymal stem cells (MSCs) Overexpressing Chemokine Receptor CCR1 Improves Cellular Engraftment and Tissue Repair of Ischemic myocardium

Circulation (2007)

Jing Huang Jian Guo Aiguo Ni Ajun Deb Lunan Zhang

Bone marrow-derived mesenchymal stem cells (BM-MSCs) may promote structural and functional repair in the myocardium following acute myocardial infarction (MI). However, the cytotactic factors/receptors responsible for MSC engraftment to the injured myocardial tissue have not been fully elucidated. Chemokines, important agents controlling cell locomotion and trafficking, are upregulated in the heart following MI and have been implicated in regulating engraftment and homing of MSCs to infarcted tissue. We hypothesized that over expression of certain chemokine receptors in MSCs will augment cell engraftment of injected MSCs in infarcted tissue. Our previous experiments indicated that CCL7(/MCP3) and SDF-1 expression was upregulated in infarcted myocardium. However, the level of expression of receptors corresponding to these chemokines in MSCs is low. In this study, we retrovirally transduced murine BM-MSCs with CCR1 or CXCR4 (receptors for CCL7 and SDF-1, respectively) genes under the control of the constitu...

CCL7

Homing (biology)

CCR1

CXC chemokine receptors

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Citations (1)

Studies on Inhibition of Antisense Phosphorothioate Oligodeoxynucleotides on Expression of HBsAg and HBeAg in Cell Culture System

Virologica Sinica (1993)

Hua Shang Lin Zhong-Yuan Hao Zhang Zong Jian-Chao Aiguo Ni

Oligomer

HBeAg

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Citations (0)

Facile and Efficient Reprogramming of Ciliary Body Epithelial Cells into Induced Pluripotent Stem Cells

Stem Cells and Development (2013)

Aiguo Ni Ming Jing Wu Yuka Nakanishi Sai H. Chavala

Induced pluripotent stem (iPS) cells are attractive for cell replacement therapy, because they overcome ethical and immune rejection issues that are associated with embryonic stem cells. iPS cells have been derived from autonomous fibroblasts at low efficiency using multiple ectopic transcription factors. Recent evidence suggests that the epigenome of donor cell sources plays an important role in the reprogramming and differentiation characteristics of iPS cells. Thus, identification of somatic cell types that are easily accessible and are more amenable for cellular reprogramming is critical for regenerative medicine applications. Here, we identify ciliary body epithelial cells (CECs) as a new cell type for iPS cell generation that has higher reprogramming efficiency compared with fibroblasts. The ciliary body is composed of epithelial cells that are located in the anterior portion of the eye at the level of the lens and is readily surgically accessible. CECs also have a reduced reprogramming requirement, as we demonstrate that ectopic Sox2 and c-Myc are dispensable. Enhanced reprogramming efficiency may be due to increased basal levels of Sox2 in CECs. In addition, we are the first to report a cellular reprogramming haploinsufficiency observed when reprogramming with fewer factors (Oct4 and Klf4) in Sox2 hemizygous cells. Taken together, endogenous Sox2 levels are critical for the enhanced efficiency and reduced exogenous requirement that permit facile cellular reprogramming of CECs.

Reprogramming

KLF4

Regenerative Medicine

Cell type

10.1089/scd.2012.0600

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Citations (9)

Inhibition of Noncanonical Murine Double Minute 2 Homolog Abrogates Ocular Inflammation through NF-κB Suppression

American Journal Of Pathology (2018)

Yan Fan Wei Zhang Aiguo Ni Biraj Mahato Sai H. Chavala

10.1016/j.ajpath.2018.05.017

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Citations (8)