Sergio Fabro

Georgetown University

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Nigel A. Brown

St George's, University of London

R. T. Williams

St Mary's Hospital

S. M. Sieber

National Institutes of Health

Robert L. Smith

Diakonhjemmet Hospital

Eugenia H. Goulding

National Institute of Environmental Health Sciences

John A. McLachlan

Tulane University

Gary E. Shull

University of Cincinnati Medical Center

Herbert Schumacher

Robert Bosch (Germany)

Anthony R. Scialli

Foundation for Reproductive Medicine

Nancy M. Dames

Georgetown University

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National Institutes of Health

George Washington University

National Institute of Environmental Health Sciences

Washington University Medical Center

National Cancer Institute

University of California, Davis

University of North Carolina at Chapel Hill

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Wayne State University

Imperial College London

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On Predicting Environmentally-Induced Human Reproductive Hazards: An Overview and Historical Perspective

Toxicological Sciences (1985)

Sergio Fabro

On Predicting Environmentally-Induced Human Reproductive Hazards: An Overview and Historical Perspective. Fabro, S. (1985). Fundam. Appl. Toxicol. 5, 609–614

10.1093/toxsci/5.4.609

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Teratogenicity and lethality of hydantoin derivatives in the mouse: Structure-toxicity relationships

Toxicology and Applied Pharmacology (1982)

Nigel A. Brown Gary E. Shull John Y. Kao Eugenia H. Goulding Sergio Fabro

Lethality

Hydantoin

10.1016/0041-008x(82)90223-x

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Citations (17)

Fetal lung lamellar bodies in human amniotic fluid.

PubMed (1978)

Gary E. R. Hook Linda Gilmore E. G. Tombropoulos Sergio Fabro

Amniotic fluid from women near term contains lamellar bodies resembling those of the pulmonary alveolar Type II cell. A lamellar body-rich fraction was prepared by differential centrifugation of am...

Lamellar granule

10.1164/arrd.1978.117.3.541

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Citations (41)

Teratogenic activity of thalidomide and related compounds

Life Sciences (1964)

Sergio Fabro Herbert Schumacher Robert L. Smith R. T. Williams

Cereblon

Pomalidomide

10.1016/0024-3205(64)90109-2

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Citations (28)

Physiological disposition of pentobarbital in tumor-bearing mice.

PubMed (1975)

William T. Beck H. George Mandel Sergio Fabro

Pentobarbital depressed macromolecular synthesis in Ehrlich ascites cells in vitro, and this depression was proportional to a decrease in oxygen consumption. However, survival time of animals bearing Ehrlich ascites cells was unaffected by pentobarbital. The acute toxicity of the drug was greatly enhanced by the presence of the tumor. Sleeping time was prolonged in mice carrying the following tumors: Ehrlich ascites, Sarcoma 180 ascites, and Yancy plasma cell solid. Seven-day Ehrlich ascites tumor-bearing animals treated with pentobarbital slept about three times longer than normal mice, but both groups awoke at the same plasma levels of the unbound drug. The plasma half-life of unchanged pentobarbital was about four times as long in tumor-bearing mice as it was in controls. No qualitative difference in catabolism other than rate was detected. Renal excretion of unchanged pentobarbital in tumor-bearing animals was 50% of control animals during the first 4 hr. In tumor-bearing mice the sleeping time of the nonmetabo ble barbiturate, barbital, was identical with that in normal animals. These data suggest that the tumor affected mainly pentobarbital metabolism. Tumor-bearing mice still responded to the pharmacological challenge of phenobarbital with the apparent induction of drug metabolizing enzymes. The prolonged pentobarbital sleeping time in tumor-bearing mice required the development of some type of tumor-host relationship.

Barbiturate

Phenobarbital

Neoplasm

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Citations (14)

Evaluation of the embryotoxic activity of L-asparaginase.

PubMed (1970)

S. Lee Adamson Sergio Fabro Maiko Hahn C. E. Creech Jacqueline Whang‐Peng

Source

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Citations (6)

Ethanol Embryotoxicity

Obstetrical & Gynecological Survey (1980)

Nigel A. Brown Eugenia H. Goulding Sergio Fabro

Laboratory of Environmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Corolina, at Department of Pharmacology and Department of Obstetrics and Gynecology, George Washington University Medical Center, Washington, D. C. 20037

George (robot)

10.1097/00006254-198005000-00003

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Citations (2)

Caffeine and Nicotine penetrate the Pre-implantation Blastocyst

Nature (1969)

Sergio Fabro S. M. Sieber

10.1038/223410a0

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Citations (62)

IDENTIFICATION OF DRUGS IN THE PREIMPLANTATION BLASTOCYST AND IN THE PLASMA, UTERINE SECRETION AND URINE OF THE PREGNANT RABBIT

Journal of Pharmacology and Experimental Therapeutics (1971)

S. M. Sieber Sergio Fabro

Significant amounts of radioactivity were found in the preimplantation blastocysts and uterine secretion as well as in the endometrium and plasma of six-day pregnant rabbits receiving 1-methyl-C14-caffeine, G-H3-nicotine, 1,1-bis- p -chlorophenyl-C14-2,2,2-trichloroethane (DDT), 2-C14-barbital, 2-C14-thiopental and carbonyl-C14-isoniazid at dose levels comparable to those encountered in the human. The unchanged radioactive compounds and some of their metabolites were identified in the blastocyst, maternal plasma and urine of the treated animals with an inverse isotopic dilution technique and paper chromatography. The following radioactive metabolites have been identified in the preimplantation blastocyst as well as in the plasma: 1, 3-dimethylxanthine, 1, 7-dimethylxanthine and 1, 3-dimethyluric acid after administration of 1-methyl-C14-caffeine; cotinine and demethylcotinine after the administration of G-H3-nicotine; acetylisoniazid and isonicotinuric acid after the administration of carbonyl-C14-isoniazid. Experiments in vitro have shown that dextran of 60,000 to 90,000 molecular weight does not penetrate the six-day blastocyst, whereas 12 other compounds of smaller molecular weight, including 16,000 to 19,000 molecular weight dextran, salicylate, sulfanilamide, antipyrine and hexamethonium, enter the blastocyst at a rate which seems dependent on the lipid solubility and degree of ionization as well as molecular weight of the compound. These findings prove that a variety of drugs and other chemicals can enter the uterine secretion and the blastocyst during the preimplantation stages of gestation.

10.1016/s0022-3565(25)28761-4

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Citations (43)

Assessment of the teratogenic potential of trimethadione in the CD-1 mouse

Toxicology and Applied Pharmacology (1979)

Nigel A. Brown Gary E. Shull Sergio Fabro

Developmental toxicity

10.1016/0041-008x(79)90008-5

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Citations (31)