J. L. Benedito

Universitat Politècnica de València

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C. Castillo

Universidade de Santiago de Compostela

100

Joaquín Hernández Bermúdez

Fundación Hospital San Pedro

Marta López‐Alonso

Universidade de Santiago de Compostela

Michele Miranda

Universidade de Santiago de Compostela

Víctor Pereira

Universidade de Santiago de Compostela

J.V. García‐Pérez

Universitat Politècnica de València

ÁA

Ángel Abuelo

Michigan State University

Rodrigo Muíño

Universidade de Santiago de Compostela

Marco García‐Vaquero

University College Dublin

J. Méndez

Instituto de Investigación Marqués de Valdecilla

Cooperative Institutions

Universidade de Santiago de Compostela

Universitat Politècnica de València

Universidad Complutense de Madrid

Universidad de León

Consejo Superior de Investigaciones Científicas

Universidad de Murcia

University of Padua

Universitat de València

Universidad Autónoma de Madrid

Hospital Universitari i Politècnic La Fe

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Redox Biology in Transition Periods of Dairy Cattle: Role in the Health of Periparturient and Neonatal Animals

Antioxidants (2019)

Ángel Abuelo Joaquín Hernández Bermúdez J. L. Benedito C. Castillo

Dairy cows undergo various transition periods throughout their productive life, which are associated with periods of increased metabolic and infectious disease susceptibility. Redox balance plays a key role in ensuring a satisfactory transition. Nevertheless, oxidative stress (OS), a consequence of redox imbalance, has been associated with an increased risk of disease in these animals. In the productive cycle of dairy cows, the periparturient and neonatal periods are times of increased OS and disease susceptibility. This article reviews the relationship of redox status and OS with diseases of cows and calves, and how supplementation with antioxidants can be used to prevent OS in these animals.

10.3390/antiox8010020

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Citations (145)

The importance of the oxidative status of dairy cattle in the periparturient period: revisiting antioxidant supplementation

Journal of Animal Physiology and Animal Nutrition (2014)

Ángel Abuelo Joaquín Hernández Bermúdez J. L. Benedito C. Castillo

Summary Dairy cows are especially vulnerable to health disorders during the transition period, when they shift from late pregnancy to the onset of lactation. Diseases at this stage affect not only the animals' well‐being, but also cause a major economic impact in dairy farms, because apart from treatment costs, affected cows will not reach their peak milk‐producing capacity. The overproduction of reactive oxygen species ( ROS ) leads to oxidative stress, which has been identified as an underlying factor of dysfunctional inflammatory responses. Supplementation with vitamins and trace elements attempts to minimize the harmful consequences of excessive ROS production, thereby trying to improve animals' health status and to reduce disease incidence. However, results regarding the effects of supplementing antioxidants on dairy cows' health and performance have been inconsistent, because in most cases, the antioxidant potential of the animals was not assessed beforehand and the nutritional strategy planned accordingly. Therefore, reviewing the physiological and harmful effects of ROS production, along with the different options available for assessing the redox balance in dairy cattle and some of the key findings of different supplementation trials, could bring one step forward the on‐farm application of determinations of oxidative status for establishing nutritional strategies early enough in the dry period that could improve transition cow health.

10.1111/jpn.12273

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Citations (201)

Arsenic, cadmium, lead, copper and zinc in cattle from Galicia, NW Spain

The Science of The Total Environment (2000)

Marta López‐Alonso J. L. Benedito Michele Miranda C. Castillo Joaquín Hernández Bermúdez

10.1016/s0048-9697(99)00461-1

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Citations (148)

Toxic and essential trace element concentrations in different tissues of extensively reared sheep in northern Spain

Journal of Food Composition and Analysis (2020)

Víctor Pereira Michele Miranda Juan Felipe García Sierra J. L. Benedito Marta López‐Alonso

Mercury

Trace element

10.1016/j.jfca.2020.103709

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Citations (11)

Relationship between the essential and toxic element concentrations and the proximate composition of different commercial and internal cuts of young beef

European Food Research and Technology (2017)

Víctor Pereira Marta López‐Alonso Michele Miranda J. L. Benedito Marco García‐Vaquero

Palatability

Trace element

Proximate

Rump

10.1007/s00217-017-2888-0

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Citations (10)

Combination of supercritical CO2 and high-power ultrasound for the inactivation of fungal and bacterial spores in lipid emulsions

Ultrasonics Sonochemistry (2021)

Angela Gomez-Gomez Edmundo Brito‐de la Fuente Críspulo Gallegos J.V. García‐Pérez J. L. Benedito

For the first time, this study addresses the intensification of supercritical carbon dioxide (SC-CO2) treatments using high-power ultrasound (HPU) for the inactivation of fungal (Aspergillus niger) and bacterial (Clostridium butyricum) spores in oil-in-water emulsions. The inactivation kinetics were analyzed at different pressures (100, 350 and 550 bar) and temperatures (50, 60, 70, 80, 85 °C), depending on the microorganism, and compared to the conventional thermal treatment. The inactivation kinetics were satisfactorily described using the Weibull model. Experimental results showed that SC-CO2 enhanced the inactivation level of both spores when compared to thermal treatments. Bacterial spores (C. butyricum) were found to be more resistant to SC-CO2 + HPU, than fungal (A. niger) ones, as also observed in the thermal and SC-CO2 treatments. The application of HPU intensified the SC-CO2 inactivation of C. butyricum spores, e.g. shortening the total inactivation time from 10 to 3 min at 85 °C. However, HPU did not affect the SC-CO2 inactivation of A. niger spores. The study into the effect of a combined SC-CO2 + HPU treatment has to be necessarily extended to other fungal and bacterial spores, and future studies should elucidate the impact of HPU application on the emulsion's stability.

Aspergillus niger

Clostridium butyricum

Supercritical Carbon Dioxide

10.1016/j.ultsonch.2021.105636

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Citations (7)

Is adenosine deaminase (ADA) activity in saliva and serum a more accurate disease detection tool than traditional redox balance parameters in early-lactating dairy cows?

Veterinary Research Communications (2023)

C. Castillo Joaquín Hernández Bermúdez Juan Sotillo Rodrigo Muíño J. L. Benedito

Abstract Enzyme adenosine deaminase (ADA) is a marker of inflammation in domestic animals, but it is unclear whether it is a reliable marker of oxidative stress, especially in the transition period in dairy cows. This study aims to assess if ADA and redox status measurements in saliva provide the same utility to detect disease condition as that obtained from serum. Sixty-eight multiparous Holstein cows, between 2 and 3 weeks postpartum were selected. Five study groups were established: control (healthy), and cows with ketosis, mastitis, laminitis, and metritis. The parameters measured were ADA activity, total oxidants (TOS), antioxidants (TAC), and OSi ratio. Regarding redox status, no significant differences arise in both saliva and serum being the correlations negative and not significant. In saliva, ADA activity in healthy cows differs from those with pathological processes, having the lowest activities. In serum, ADA activity is similar in the healthy and ketosis cows, showing the lowest activities meanwhile animals with mastitis, laminitis, or metritis have significantly higher activities. In conclusion, the measurement of ADA activities and redox status in saliva does not give consistent results, being preferable to measure them in serum during the transition period.

10.1007/s11259-023-10069-2

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Citations (2)

Use of high-power ultrasound combined with supercritical fluids for microbial inactivation in dry-cured ham

Innovative Food Science & Emerging Technologies (2020)

Rosa Isela Castillo‐Zamudio I. Paniagua-Martínez Carmen Ortuño M.A. Garcı́a-Alvarado Virginia Larrea

Supercritical Carbon Dioxide

Myofibril

10.1016/j.ifset.2020.102557

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Citations (17)

Influence of grain processing in regard to serum metabolites and enzymes for finishing bull calves

Journal of Animal and Feed Sciences (2011)

C. Castillo J. L. Benedito Víctor Pereira Juan Sotillo Adriana Zamora

This study compared two grain processing methods that are widely used for beef cattle, grinding and steam pelleting, with respect to serum metabolic parameters: glucose, non-esterified fatty acids (NEFA), serum urea nitrogen (SUN), total serum protein (TSP), albumin, L-lactate, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT) and amylase.Ten Belgian Blue bull calves were allotted randomly to each of two experimental groups: PF, fed pelleted concentrate, and GF, fed ground concentrate.During the 77-day study most parameters underwent significant variation in time, increasing only numerically serum values of total protein, albumin, AST and amylase, while serum glucose, NEFA and GGT decreased numerically.Statistically significant differences were found only between groups PF and GF for creatinine (higher in group PF, in relation with its greater average body weight) and urea nitrogen, which for unknown causes fluctuated in opposite directions in the two groups throughout most of the study and attributable to changes in ruminal protein digestion.Neither serum glucose nor L-lactate were affected by treatment of grains.

10.22358/jafs/66202/2011

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Citations (1)

Acid–base status and serum l-lactate in growing/finishing bull calves fed different high-grain diets

Livestock Science (2008)

C. Castillo J. L. Benedito Víctor Pereira Patricia Vázquez Cándido Gutiérrez Panizo

Feedlot

Bicarbonate

10.1016/j.livsci.2008.04.011

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Citations (11)