Venna Venna

Atma Jaya Catholic University of Indonesia

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Jullyanny Waty Wijaya

Atma Jaya Catholic University of Indonesia

July Kumalawati

Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo

Hendri Tanjaya

Tria Asri Widowati

Atma Jaya Catholic University of Indonesia

Helen Kristin

Atma Jaya Catholic University of Indonesia

Ivonne Martin

University Medical Center Utrecht

Soegianto Ali

Atma Jaya Catholic University of Indonesia

Billy Leoprayogo

Atma Jaya Catholic University of Indonesia

Laurentius Aswin Pramono

Atma Jaya Catholic University of Indonesia

Rahajuningsih Dharma Setiabudy

University of Indonesia

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Atma Jaya Catholic University of Indonesia

University of Indonesia

Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo

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National Brain Centre

Leiden University Medical Center

Catholic University of America

Universitas Gadjah Mada

Krida Wacana Christian University

Pancasila University

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SARS-CoV-2 in 30 Months, Indonesia’s Data Tells: Study from a Reference Laboratory in North Jakarta and Its Reflection for Regional to National COVID-19 Situation

medRxiv (Cold Spring Harbor Laboratory) (2023)

Maria Mardalena Martini Kaisar Tria Asri Widowati Helen Kristin Sheila Jonnatan Sem Samuel Surja

Abstract Atma Jaya Catholic University of Indonesia (AJCUI) COVID-19 Laboratory has become a reference testing site, which contributed to prevent the SARS-CoV-2 transmission in Indonesia. Through the LSSR and CARE, the Indonesian government has implemented moderate yet arguably successful policies to combat this pandemic. This study aims to assess and strengthen public health management while enhancing our understanding of the dynamics of COVID-19. We analyzed the correlation between policies enforced in controlling COVID-19 from July 2020–December 2022 to the positivity rate and viral intensity. AJCUI, DKI Jakarta, Indonesia demonstrated a similar trend in COVID-19 prevalence. Government policy on mobility restrictions has substantially reduced the positivity rate in Indonesia within the period of study. Our study interpreted that the Ct value in the positive case population of AJCUI data correlated positively with DKI Jakarta and Indonesia; subsequently, it has the potential to serve as an early warning for an anticipated wave. Despite the coverage of vaccines, AJCUI and DKI Jakarta positivity rates are shifting due to evolving virus variants. Altogether, the comprehensively recorded data would enable an understanding of COVID-19 dynamics, serve as a model for unprecedented disaster and public health management in general.

Pandemic

Indonesian government

2019-20 coronavirus outbreak

10.1101/2023.07.27.23293237

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Correlation Between Vitreous Advanced Glycation End Products, and D-dimer with Blood HbA1c Levels in Proliferative Diabetic Retinopathy.

DOAJ (DOAJ: Directory of Open Access Journals) (2018)

Tonny Loho Venna Venna Rahajuningsih Dharma Setiabudy Ninik Sukartini Suzanna Immanuel

proliferative diabetic retinopathy (DR) is an advanced form of DR that eventually could lead to blindness. Levels of vitreous advanced glycation end products (AGEs) and D-dimer may reflect the pathological changes in the retina, but only few studies have assessed their correlation with blood hemoglobin A1C (HbA1c) levels. This study aimed to find the association between blood HbA1c levels with vitreous AGEs and D-dimer levels in patients with proliferative DR.an analytical cross-sectional study was performed in subjects with proliferative DR who underwent vitrectomy. Subjects were divided into 2 subgroups, i.e. uncontrolled (HbA1c >7%) and controlled (HbA1c <7%) groups. Vitreous AGEs and D-dimer levels were assessed; the levels were compared between uncontrolled and controlled hyperglycemic patients. Statistic correlation tests were also performed for evaluating blood HbA1c, vitreous AGEs, and D-dimer levels.a total of 47 patients were enrolled in this study and 32 (68.1%) of them were women. Median vitreous AGEs level was 11.0 (3.0 - 48.0) µg/mL; whereas median vitreous D-dimers level was 5,446.0 (44.0 - 37,394.0 ) ng/mL. The median vitreous AGEs levels was significantly higher in patients with uncontrolled vs. controlled hyperglycemia (14.0 vs. 4.0 mg/mL; p<0.001). There was a significant positive correlation with moderate strength between blood HbA1c level and vitreous AGEs level (r=0.524; r2=0.130; p=0.0001). Blood HbA1c level could be used to predict vitreous AGEs level by using the following calculation: vitreous AGEs = -1.442+ (1.740xblood HbA1c). Vitreous D-dimer levels were not significantly different between uncontrolled and controlled hyperglycemia (median 4607.5 vs. 5701.6 ng/mL; p = 0.458). There was a positive significant correlation between blood HbA1c and vitreous D-dimer levels (r = 0.342; p = 0.019); however the correlation was weak. Vitreous AGEs level had a positive significant correlation with vitreous D-dimer levels (r = 0.292; p = 0.046) and the correlation strength was also weak.median vitreous AGEs levels were significantly higher in proliferative DR patients with uncontrolled than those with controlled hyperglycemia. Blood HbA1c level can be used to assess vitreous AGEs level in patients with proliferative DR by using the following calculation: vitreous AGEs = -1.442+(1.740 x HbA1c). However, the blood HbA1c level can not be used to predict vitreous D-dimer level in patients with proliferative DR.

D-dimer

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FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN ANEMIA PADA PASIEN DIABETES MELITUS TIPE 2: SEBUAH KAJIAN SISTEMATIS

Medika Kartika Jurnal Kedokteran dan Kesehatan (2024)

Hendri Tanjaya Regina Satya Wiraharja Laurentius Aswin Pramono Venna Venna

Diabetes melitus tipe 2 (DM2) merupakan penyakit kronik dengan mortalitas yang tinggi dan berdampak pada kesejahteraan masyarakat. Anemia merupakan salah satu komplikasi yang paling sering terjadi pada DM2. Beberapa penelitian sudah menggali mengenai faktor-faktor tersebut, tetapi sepengetahuan penulis penelitian-penelitian tersebut masih mendapatkan hasil yang bertentangan dan masih sedikit yang dilakukan di Indonesia. Kajian sistematis ini bertujuan untuk mengetahui factor-faktor yang berhubungan dengan kejadian anemia pada pasien DM2. Kepustakaan pada kajian sistematis ini ditelusuri melalui database berupa Google scholar dan Pubmed dengan kata kunci “diabetes melitus tipe 2”, “faktor risiko” dan “anemia”. Hasil pencarian kepustakaan mendapatkan 977 kepustakaan dengan 9 kepustakaan yang membahas mengenai faktor risiko kejadian anemia pada DM2. Kajian sistematis ini menemukan bahwa usia, jenis kelamin, indeks massa tubuh, durasi penyakit, jenis pengobatan, kadar HbA1c, dan tekanan darah merupakan faktor-faktor yang berkontribusi terhadap kejadian anemia pada DM2. Oleh karena itu, penting untuk memasukkan skrining anemia ke dalam penilaian rutin komplikasi terkait DM yang menargetkan jenis kelamin perempuan, usia yang lebih tua, indeks massa tubuh overweight, kontrol glikemik yang buruk, tekanan darah yang tinggi, dan durasi penyakit diabetes yang lama. Kata kunci: anemia, diabetes melitus tipe 2, faktor risiko

10.35990/mk.v7n3.p319-330

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Perbandingan pemeriksaan kadar glukosa darah mandiri dengan uji laboratorium menggunakan metode baku emas

Damianus Journal of Medicine (2023)

Venna Venna Jullyanny Waty Wijaya Gregorio Gavriel Singgih Christian Ardianto

ABSTRAK Pendahuluan: Ketersediaan point of care testing (POCT) saat ini dipakai secara luas untuk melakukan pemantauan glukosa darah mandiri (PGDM) bagi pada pasien diabetes. Berbagai pilihan alat POCT meggunakan metode glukosa dehidrogenase sudah tersedia saat ini. Penelitian ini berupaya membandingkan berbagai alat POCT dengan metode heksokinase yang merupakan baku emas dari pemeriksaan glukosa darah. Metode: Subjek penelitian merupakan subjek dewasa muda dengan rentang usia 18-21 tahun, dengan kriteria eksklusi sedang sakit berat, terdapat luka pada lokasi pengambilan darah, memiliki riwayat gangguan pembekuan darah, dan hasil pemeriksaan glukosa darah >200 mg. Pengambilan sampel dilakukan secara potong lintang. Sampel yang akan diambil berupa darah kapiler yang langsung akan diujikan pada alat POCT dan sampel darah vena yang akan diuji menggunakan metode heksokinase. Analisis statistik dilakukan dengan menggunakan STATA versi 14.0. Data yang diperoleh akan dianalisis menggunakan Bland-Altman plot. Hasil: Didapatkan hasil glukosa darah POCT alat AccuChek Performa dan AccuChek Instant memiliki rerata perbedaan yang bernilai negatif dan untuk GlucoDrAuto memiliki rerata perbedaan yang lebih mendekati angka nol dibandingkan dengan alat AccuChek Performa dan AccuChek Instant. Simpulan: Metode POCT dapat membantu dalam pemantauan glukosa darah pasien, tidak dapat menggantikan metode heksokinase.

10.25170/djm.v22i2.4235

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Correlation between Hemoglobin Concentration and Cardiorespiratory Fitness in Adolescent Sportsmen

Althea Medical Journal (2020)

Billy Leoprayogo Venna Venna Ignatio Rika Haryono Francisca Tjhay

Background: Sport is a physical activity that increases human body oxygen demand. Hemoglobin has a major role to fulfill the oxygen demand. The body capacity to fulfill the increasing oxygen demand could be seen as cardiorespiratory fitness. Sportsmen have a high cardiorespiratory fitness due to the intensity and frequency of training. This study aimed to explore how hemoglobin concentration affects the cardiorespiratory fitness of adolescence sportsmen. Method: This study used a cross-sectional approach. The sampling started in October – November 2019. Sample of this study were 15-19 years old male badminton and basketball sportsmen at Jakarta and Bogor (n=72). Hemoglobin concentration measured with a digital hemoglobinometer which used an azide-methemoglobin method. VO 2 max estimated with a beep test. FITNESSGRAM® Performance Standard was used for the classification of cardiorespiratory fitness. All measurement’s ethical issues had been approved. The result of hemoglobin concentration and cardiorespiratory fitness was processed by SPSS program with Spearman and Kruskal-Wallis analysis method. Results: There was a correlation between hemoglobin concentration and cardiorespiratory fitness (p = 0.001, p < 0.05). Spearman analysis showed there was a weak correlation (r = 0.38) between hemoglobin concentration and cardiorespiratory fitness. Kruskal-Wallis analysis showed there was a meaningful mean difference in hemoglobin concentration on cardiorespiratory fitness groups (p = 0.005, p < 0.05). Conclusion: The mean of the hemoglobin concentration on the Healthy Fitness Zone (HFZ) cardiorespiratory group was higher than on the Need Improvement (NI) group and the Need Improvement within Health Risk (NI-HR) group.

10.15850/amj.v7n2.1847

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