Fabrice Favret

Université de Strasbourg

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Jean‐Paul Richalet

Université Sorbonne Paris Nord

Stéphane Dufour

Université de Strasbourg

Bernard Gény

Université de Strasbourg

Thomas J. Hureau

Université de Strasbourg

Aurélien Pichon

Université de Poitiers

Marie-Ève Isner-Horobeti

Mitochondrie, stress oxydant et protection musculaire

Evelyne Lonsdorfer

Université de Strasbourg

Anne‐Laure Charles

Université de Strasbourg

Dominique Marchant

Université Sorbonne Paris Nord

Joris Mallard

Université de Strasbourg

Cooperative Institutions

Université de Strasbourg

Inserm

Mitochondrie, stress oxydant et protection musculaire

Université Paris Cité

Hôpitaux Universitaires de Strasbourg

Université Sorbonne Paris Nord

Hôpital Civil, Strasbourg

Centre National de la Recherche Scientifique

Sorbonne Paris Cité

Universidade de São Paulo

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Use of botulinum toxin type A in symptomatic accessory soleus muscle: first five cases

Scandinavian Journal of Medicine and Science in Sports (2015)

Marie-Ève Isner-Horobeti G. Muff Evelyne Lonsdorfer‐Wolf C. Deffinis J. Masat

Symptomatic accessory soleus muscle ( ASM ) can cause exercise‐induced leg pain due to local nerve/vascular compression, muscle spasm, or local compartment syndrome. As intramuscular injections of botulinum toxin type A ( BTX ‐A) can reduce muscle tone and mass, we investigated whether local BTX ‐A injections relieve the pain associated with symptomatic ASM . We describe five patients presenting peri/retromalleolar exertional pain and a contractile muscle mass in the painful region. Com‐pression neuropathy was ruled out by electromyo‐graphic analysis of the lower limb muscles. Doppler ultrasonography was normal, excluding a local vascular compression. ASM was confirmed by magnetic resonance imaging. After a treadmill stress test, abnormal intramuscular pressure values in the ASM , confirmed the diagnosis of compartment syndrome only in one patient. All five patients received BTX ‐A injections in two points of the ASM . The treatment efficacy was evaluated based on the disappearance of exercise‐induced pain and the resumption of normal physical and sports activities. After BTX ‐A injection, exertional pain disappeared and all five patients resumed their normal level of physical and sports performances. Neither side effects nor motor deficits were observed. BTX ‐A is well tolerated in patients with ASM and could be used as a new conservative therapeutic strategy for the treatment of symptomatic ASM before surgery.

muscle spasm

10.1111/sms.12616

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Citations (11)

Évaluation de l’intérêt du réentraînement à l’effort dans la sclérose en plaques et accompagnement des patients dans leur pratique sportive

Annals of Physical and Rehabilitation Medicine (2014)

Marie-Ève Isner-Horobeti P. Zaencker Evelyne Lonsdorfer P. Vautravers Fabrice Favret

10.1016/j.rehab.2014.03.1138

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Characterisation of the ventilatory response to hypoxia in a model of transgenic anemic mice

Respiratory Physiology & Neurobiology (2005)

José Luis Macarlupú A. Buvry O.E. Morel Fabiola Lèon‐Velarde Jean‐Paul Richalet

Hypoxic ventilatory response

Hypoxia

Hyperoxia

10.1016/j.resp.2005.03.011

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Pressure overload-induced mild cardiac hypertrophy reduces left ventricular transmural differences in mitochondrial respiratory chain activity and increases oxidative stress

Frontiers in Physiology (2012)

Michel Kindo Sébastien Gerelli Jamal Bouitbir Anne‐Laure Charles Joffrey Zoll

Increased mechanical stress and contractility characterizes normal left ventricular (LV) subendocardium (Endo) but whether Endo mitochondrial respiratory chain complex activities is reduced as compared to subepicardium (Epi) and whether pressure overload-induced LV hypertrophy (LVH) might modulate transmural gradients through increased reactive oxygen species (ROS) production is unknown.LVH was induced by 6 weeks abdominal aortic banding and cardiac structure and function were determined with echocardiography and catheterization in sham-operated and LVH rats (n = 10 for each group). Mitochondrial respiration rates, coupling, content and ROS production were measured in LV Endo and Epi, using saponin-permeabilized fibers, Amplex Red fluorescence and citrate synthase activity.In sham, a transmural respiratory gradient was observed with decreases in endo maximal oxidative capacity (-36.7%, P < 0.01) and complex IV activity (-57.4%, P < 0.05). Mitochondrial hydrogen peroxide (H(2)O(2)) production was similar in both LV layers. Aortic banding induced mild LVH (+31.7% LV mass), associated with normal LV fractional shortening and end diastolic pressure. LVH reduced maximal oxidative capacity (-23.6 and -33.3%), increased mitochondrial H(2)O(2) production (+86.9 and +73.1%), free radical leak (+27.2% and +36.3%) and citrate synthase activity (+27.2% and +36.3%) in Endo and Epi, respectively. Transmural mitochondrial respiratory chain complex IV activity was reduced in LVH (-57.4 vs. -12.2%; P = 0.02).Endo mitochondrial respiratory chain complexes activities are reduced compared to LV Epi. Mild LVH impairs mitochondrial oxidative capacity, increases oxidative stress and reduces transmural complex IV activity. Further studies will be helpful to determine whether reduced LV transmural gradient in mitochondrial respiration might be a new marker of a transition from uncomplicated toward complicated LVH.

Pressure overload

Contractility

Ventricular pressure

10.3389/fphys.2012.00332

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Cardiorespiratory Responses to Downhill Versus Uphill Running in Endurance Athletes

Research Quarterly for Exercise and Sport (2018)

Marcel Lemire Evelyne Lonsdorfer‐Wolf Marie-Ève Isner-Horobeti Blah Y.L. Kouassi Bernard Gény

Mountain running races are becoming increasingly popular, although our understanding of the particular physiology associated with downhill running (DR) in trained athletes remains scarce. This study explored the cardiorespiratory responses to high-slope constant velocity uphill running (UR) and DR.Eight endurance athletes performed a maximal incremental test and 2 15-min running bouts (UR, +15%, or DR, -15%) at the same running velocity (8.5 ± 0.4 km·h-1). Oxygen uptake ([Formula: see text]O2), heart rate (HR), and ventilation rates ([Formula: see text]E) were continuously recorded, and blood lactate (bLa) was measured before and after each trial.Downhill running induced a more superficial [Formula: see text]E pattern featuring reduced tidal volume (p < .05, ES = 6.05) but similar respiratory frequency (p > .05, ES = 0.68) despite lower [Formula: see text]E (p < .05, ES = 5.46), [Formula: see text]O2 (p < .05, ES = 12.68), HR (p < .05, ES = 6.42), and bLa (p < .05, ES = 1.70). A negative slow component was observed during DR for [Formula: see text]O2 (p < .05, ES = 1.72) and HR (p < .05, ES = 0.80).These results emphasize the cardiorespiratory responses to DR and highlight the need for cautious interpretation of [Formula: see text]O2, HR, and [Formula: see text]E patterns as markers of exercise intensity for training load prescription and management.

Respiratory minute volume

Exercise prescription

Incremental exercise

10.1080/02701367.2018.1510172

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Erythropoietin and the use of a transgenic model of erythropoietin-deficient mice

Hypoxia (2016)

Jean‐Paul Richalet Aurélien Pichon Florine Jeton Raja El Hasnaoui-Saadani Luciana Hagström

Abstract: Despite its well-known role in red blood cell production, it is now accepted that erythropoietin (Epo) has other physiological functions. Epo and its receptors are expressed in many tissues, such as the brain and heart. The presence of Epo/Epo receptors in these organs suggests other roles than those usually assigned to this protein. Thus, the aim of this review is to describe the effects of Epo deficiency on adaptation to normoxic and hypoxic environments and to suggest a key role of Epo on main physiological adaptive functions. Our original model of Epo-deficient (Epo-TAg h ) mice allowed us to improve our knowledge of the possible role of Epo in O 2 homeostasis. The use of anemic transgenic mice revealed Epo as a crucial component of adaptation to hypoxia. Epo-TAg h mice survive well in hypoxic conditions despite low hematocrit. Furthermore, Epo plays a key role in neural control of ventilatory acclimatization and response to hypoxia, in deformability of red blood cells, in cerebral and cardiac angiogenesis, and in neuro- and cardioprotection. Keywords: Epo-TAg h mice, mouse model, physiological functions, hypoxia

Hypoxia

Cardioprotection

Erythropoietin receptor

10.2147/hp.s83540

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despite several skeletal muscle metabolic adaptations Mitochondrial uncoupling reduces exercise capacity

Bernard Gény Joffrey Zoll François Singh Anne‐Laure Charles T. Gali

Source

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Blood Rheology, Blood Flow, and Human Health

Elsevier eBooks (2018)

Philippe Connes Stéphane Dufour Aurélien Pichon Fabrice Favret

10.1016/b978-0-12-813922-6.00030-8

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Citations (4)

Development of skeletal muscle atrophy and intermuscular adipose tissue in patients with early breast cancer treated with chemotherapy

AJP Cell Physiology (2022)

Joris Mallard Elyse Hucteau Laura Bender Anouk Charlot L. Debrut

Chemotherapy is a common therapy to treat patients with breast cancer but also leads to skeletal muscle deconditioning. Skeletal muscle deconditioning is multifactorial and intermuscular adipose tissue (IMAT) accumulation is closely linked to muscle dysfunction. To date, there is no clinical study available investigating IMAT development through a longitudinal protocol and the underlying mechanisms remain unknown. Our study was dedicated to investigating IMAT content in patients with early breast cancer who were treated with chemotherapy and exploring the subsequent cellular mechanisms involved in its development. We included 13 women undergoing chemotherapy. Muscle biopsies and ultrasonography assessment were performed before and after chemotherapy completion. Histological and Western blotting analyses were conducted. We found a substantial increase in protein levels of three mature adipocyte markers (perilipin, +901%; adiponectin, +135%; FABP4, +321%; P < 0.05). These results were supported by an increase in oil red O-positive staining (+358%; P < 0.05). A substantial increase in PDGFRα protein levels was observed (+476%; P < 0.05) highlighting an increase in fibro-adipogenic progenitors (FAPs) content. The cross-sectional area of the vastus lateralis muscle fibers substantially decreased (-21%; P < 0.01), and muscle architecture was altered, as shown by a decrease in fascicle length (-15%; P < 0.05) and a decreasing trend in muscle thickness (-8%; P = 0.08). We demonstrated both IMAT development and muscle atrophy in patients with breast cancer who were treated with chemotherapy. FAPs, critical stem cells inducing both IMAT development and skeletal muscle atrophy, also increased, suggesting that FAPs likely play a critical role in the skeletal muscle deconditioning observed in patients with breast cancer who were treated with chemotherapy.

Muscle Atrophy

10.1152/ajpcell.00373.2022

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Citations (6)

Évaluation de l’intérêt de l’entraînement combiné dans la sclérose en plaques et accompagnement des patients dans leur pratique sportive

Revue Neurologique (2015)

Pierre Zaenker Fabrice Favret Marie-Ève Isner-Horobeti Eveline Lonsdorfer de Sèze

10.1016/j.neurol.2015.01.186

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