In B2B e-Marketplace for free gifts and goods, product-mix recommendation is provided frequently by analysing customer logs and/or performing collaborative and rules-based filtering. This study proposes a new process that encompasses the genetic algorithm and key working processes of B2B e-marketplace based on the previous cooperate client order data. Efficiency and accuracy of the proposed system have been confirmed by cross-confirmation of accumulated data in the e-marketplace. The system can provide better opportunities for manufactures and suppliers to select optimized product-mix without time consuming trials and errors in their B2B e-marketplace networks.
Background Depression has been associated with the risk of developing physical illnesses and diseases. Inflammatory hypotheses of immunoactive and dysregulated cytokine production have been proposed to describe this association; however, data pertaining to the high prevalence of depression among nurses are limited. Objective This study aimed to use a comprehensive immune-profiling approach to determine whether an abnormal profile of circulating cytokines could be identified in nurses with self-reported depression and whether this profile is associated with the severity of depression. Methods We investigated a cohort of 157 female nurses in Korea. The self-report Patient Health Questionnaire was used to measure the depression levels of nurses. In addition, peripheral blood samples were collected and used to measure the cytokine profile using the Luminex multiplexing system. Generalized gamma regression analyses were conducted to evaluate the association between cytokine and depressive symptoms. Results Regarding severity of depressive symptoms, 28.0% of nurses had moderately severe depression while 9.6% had severe depression. Moderately-severe depressive symptoms in nurses were associated with elevated levels of interleukin-6 ( B = 0.460, p = 0.003), interleukin-8 ( B = 0.273, p = 0.001), and interleukin-18 ( B = 0.236, p = 0.023), whereas interferon-gamma levels ( B = −0.585, p = 0.003) showed the opposite profile. Participants with severe depressive symptoms presented decreased interferon-gamma levels ( B = −1.254, p < 0.001). Conclusion This study demonstrated that proinflammatory cytokines were associated with depression among nurses. This calls for early detection and intervention, considering the mechanisms linking depression to physical illness and disease.
본 논문은 조달청 종합쇼핑몰 공공데이터를 체계적으로 활용하여 ARIMA 모형 기반의 시장수요예측 프로그램을 구현하였다. 최근 공공데이터의 활용과 연구에 대한 관심이 높아지고 있으나, 공공데이터의 수집, 가공 및 분석을 체계적으로 수행한 연구는 제한적인 실정이다. 공공데이터를 활용하여 분석하기 위해서는 관련데이터의 속성을 구체적으로 파악하여 사용자의 의도에 맞도록 데이터를 추출하여야 하며, 이를 토대로 연구하고자 하는 방법론을 적용하여야 하지만, 현재까지의 연구에서는 이를 처리하는 데 한계가 있었다. 본 연구는 이러한 한계점을 보완하고자 공공에서 제공하는 데이터의 속성을 파악하고 추출하였으며, 프로그래밍을 통하여 일괄적으로 부문별 시장규모를 예측할 수 있는 방법을 제시하였다. ARIMA 모형의 단위근 검정, 모형식별, 모형추정 및 모형검증에 대한 전 과정을 프로그래밍화하여 일괄적으로 처리하고 예측함으로써 공공데이터의 처리와 분석이 가능함을 제시하였다. 분석결과 MAPE 값이 3.90%~ 24.47%로 본 연구에서 구현한 ARIMA 모형을 이용한 처리방법이 우수한 것으로 나타났다.
Nonalcoholic steatohepatitis (NASH) is the most prevalent chronic liver disease worldwide and increases the risk for hepatocellular carcinoma (HCC) in developed countries. However, no medications have been approved to protect against NASH-driven HCC. Dapagliflozin, a sodium glucose cotransporter-2 (SGLT-2) inhibitor, improves hyperglycemia by promoting glycosuria. We investigated whether dapagliflozin prevents NASH-driven HCC using a mouse model. Diethylnitrosamine (25 mg/kg) was intraperitoneally injected into 2-week-old C57BL6/J male mice, followed by either normal chow diet or 60% high-fat diet (HFD) for 30 weeks with or without dapagliflozin, 0.003% (w/w). HFD-fed mice without dapagliflozin had an increased number of tumor on liver surface compared with chow-fed mice (77.0 vs. 12.5/per mouse; n=6 per group; p=0.01). The number of liver tumors was significantly lower in dapagliflozin treated group (19.5/per mouse in dapagliflozin-treated HFD-fed mice; n=6) than that in HFD-fed mice without dapagliflozin (p=0.03). Dapagliflozin treatment numerically reduced body weight and fasting blood glucose compared with HFD-fed mice without dapagliflozin (41.0 vs. 40.2 g, p=0.94 for body weight, and 196.3 vs. 170.8 mg/dL, p=0.34 for fasting blood glucose). In addition, several human HCC cell lines (Huh 7, HepG2, and Hep3B) expressed SGLT-2 protein. Thus, it is possible that dapagliflozin might directly modulate HCC development via SGLT-2 inhibition. In conclusion, dapagliflozin attenuates NASH-associated HCC development possibly via its direct effect on HCC. Disclosure M. Lee: None. H. Lee: None. E. Kang: None. Y. Kim: None. S. Lee: None. H. Kim: None. S. Lee: None. J. Kim: None. S. Kim: None. R. Kim: None. H. Park: None.
'%3e%3cg id='b'%3e%3cpath id='a' stroke='%23000' stroke-width='2' d='M-6-25H6m-12 3H6m-12 3H6'/%3e%3cuse xlink:href='%23a' y='44'/%3e%3c/g%3e%3cpath stroke='%23fff' d='M0 17v10'/%3e%3ccircle r='12' fill='%23cd2e3a'/%3e%3cpath fill='%230047a0' d='M0-12A6 6 0 0 0 0 0a6 6 0 0 1 0 12 12 12 0 0 1 0-24z'/%3e%3c/g%3e%3cg transform='rotate(-123.69)'%3e%3cuse xlink:href='%23b'/%3e%3cpath stroke='%23fff' d='M0-23.5v3M0 17v3.5m0 3v3'/%3e%3c/g%3e%3c/svg%3e)