Valeria Berton

University of Verona

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Francesco Bifari

University of Milan

Ilaria Decimo

University of Verona

Mauro Krampera

University of Verona

Guido Francesco Fumagalli

University of Verona

Giorgio Malpeli

Link Campus University

Annachiara Pino

University of Verona

Alice Braga

University College London

F.J. Rodríguez

Instituto de Astronomía Teórica y Experimental

Tobia Pretto

Istituto Zooprofilattico Sperimentale delle Venezie

Francesco Montesi

Istituto Zooprofilattico Sperimentale delle Venezie

Cooperative Institutions

University of Verona

University of Padua

Istituto Zooprofilattico Sperimentale delle Venezie

University of Milan

University of Bologna

Friedrich-Alexander-Universität Erlangen-Nürnberg

Azienda Ospedaliera Universitaria Integrata Verona

Ruhr University Bochum

University of Milano-Bicocca

Faculdade de Medicina do ABC

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OLIGODENDROCYTES FROM SPINAL CORD MENINGES: AMPLIFICATION, CHARACTERIZATION AND TRANSPLANTATION IN CONTUSIVE INJURY

Valeria Berton

Meninges

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Ultrastructural and molecular characterization of Vairimorpha austropotamobii sp. nov. (Microsporidia: Burenellidae) and Thelohania contejeani (Microsporidia: Thelohaniidae), two parasites of the white-clawed crayfish, Austropotamobius pallipes complex (Decapoda: Astacidae)

Journal of Invertebrate Pathology (2017)

Tobia Pretto Francesco Montesi Daniela Ghia Valeria Berton Miriam Abbadi

Polar filament

10.1016/j.jip.2017.11.002

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Citations (22)

Meninges harbor cells expressing neural precursor markers during development and adulthood

Frontiers in Cellular Neuroscience (2015)

Francesco Bifari Valeria Berton Annachiara Pino Marijana Kusalo Giorgio Malpeli

Brain and skull developments are tightly synchronized, allowing the cranial bones to dynamically adapt to the brain shape. At the brain-skull interface, meninges produce the trophic signals necessary for normal corticogenesis and bone development. Meninges harbor different cell populations, including cells forming the endosteum of the cranial vault. Recently, we and other groups have described the presence in meninges of a cell population endowed with neural differentiation potential in vitro and, after transplantation, in vivo. However, whether meninges may be a niche for neural progenitor cells during embryonic development and in adulthood remains to be determined. In this work we provide the first description of the distribution of neural precursor markers in rat meninges during development up to adulthood. We conclude that meninges share common properties with the classical neural stem cell niche, as they: (i) are a highly proliferating tissue; (ii) host cells expressing neural precursor markers such as nestin, vimentin, Sox2 and doublecortin; and (iii) are enriched in extracellular matrix components (e.g., fractones) known to bind and concentrate growth factors. This study underlines the importance of meninges as a potential niche for endogenous precursor cells during development and in adulthood.

Meninges

Cranial vault

Precursor cell

Corticogenesis

10.3389/fncel.2015.00383

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Vegetative incompatibility and potential involvement of a mycovirus in the Italian population of Geosmithia morbida

DOAJ (DOAJ: Directory of Open Access Journals) (2015)

Lucio Montecchio Genny Fanchin Valeria Berton Linda Scattolin

Studies carried out during an Italian outbreak of the Thousand Cankers Disease of walnut, demonstrated that non-coalescing cankers on host plants, separated by equidistant uninfected zones, were associated with incompatible strains of Geosmithia morbida . Confirmation of the vegetative incompatibility of paired fungal isolates, randomly collected from black walnuts, was obtained from observations of a clear separation zones and the absence of anastomoses. Pairing tests with two incompatible monoconidial strains indicated differences in morphology and growth rates. Electron microscopy revealed the presence of icosahedral mycovirus-like particles in one of the monoconidial strains that demonstrated low degrees of virulence in planta compared with a particle-free monoconidial strain. The occurrence of a vegetative incompatibility system in recently introduced populations of G. morbida has considerable implications for fungal biology. Incompatibility in G. morbida and potential direct or indirect roles of the observed virus-like particles have potential ecological and epidemiological consequences.

Mycovirus

10.14601/phytopathol_mediterr-16376

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Sturgeon Nucleocytoplasmic Large DNA Virus and Acinetobacter spp. Co-infection: Pathological Findings in a Disease Outbreak

Journal of Comparative Pathology (2017)

Sara Ciulli Enrico Volpe Rubina Sirri Pier Luca Passalacqua Federica Bianchi

10.1016/j.jcpa.2016.11.122

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Meninges as a niche for stem/precursor cells with neural differentiation potential during development up to adulthood

Ilaria Decimo Francesco Bifari Marijana Kusalo Valeria Berton Annachiara Pino

Meninges

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Intracellular Trafficking of Guanylate-Binding Proteins Is Regulated by Heterodimerization in a Hierarchical Manner

PLoS ONE (2010)

Nathalie Britzen‐Laurent Michael Bauer Valeria Berton Nicole Fischer Adrian Syguda

Guanylate-binding proteins (GBPs) belong to the dynamin family of large GTPases and represent the major IFN-γ-induced proteins. Here we systematically investigated the mechanisms regulating the subcellular localization of GBPs. Three GBPs (GBP-1, GBP-2 and GBP-5) carry a C-terminal CaaX-prenylation signal, which is typical for small GTPases of the Ras family, and increases the membrane affinity of proteins. In this study, we demonstrated that GBP-1, GBP-2 and GBP-5 are prenylated in vivo and that prenylation is required for the membrane association of GBP-1, GBP-2 and GBP-5. Using co-immunoprecipitation, yeast-two-hybrid analysis and fluorescence complementation assays, we showed for the first time that GBPs are able to homodimerize in vivo and that the membrane association of GBPs is regulated by dimerization similarly to dynamin. Interestingly, GBPs could also heterodimerize. This resulted in hierarchical positioning effects on the intracellular localization of the proteins. Specifically, GBP-1 recruited GBP-5 and GBP-2 into its own cellular compartment and GBP-5 repositioned GBP-2. In addition, GBP-1, GBP-2 and GBP-5 were able to redirect non-prenylated GBPs to their compartment in a prenylation-dependent manner. Overall, these findings prove in vivo the ability of GBPs to dimerize, indicate that heterodimerization regulates sub-cellular localization of GBPs and underscore putative membrane-associated functions of this family of proteins.

Immunoprecipitation

10.1371/journal.pone.0014246

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Citations (123)

Migration of meningeal cells in response to contusive spinal cord injury

Valeria Berton Francesco Bifari Rodriguez Francisco Javier Mauro Krampera Guido Francesco Fumagalli

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Susceptibility to and transmission of H5N1 and H7N1 highly pathogenic avian influenza viruses in bank voles (Myodes glareolus)

Veterinary Research (2015)

A. Romero Tejeda Roberta Aiello Angela Salomoni Valeria Berton Marta Vascellari

The study of influenza type A (IA) infections in wild mammals populations is a critical gap in our knowledge of how IA viruses evolve in novel hosts that could be in close contact with avian reservoir species and other wild animals. The aim of this study was to evaluate the susceptibility to infection, the nasal shedding and the transmissibility of the H7N1 and H5N1 highly pathogenic avian influenza (HPAI) viruses in the bank vole (Myodes glareolus), a wild rodent common throughout Europe and Asia. Two out of 24 H5N1-infected voles displayed evident respiratory distress, while H7N1-infected voles remained asymptomatic. Viable virus was isolated from nasal washes collected from animals infected with both HPAI viruses, and extra-pulmonary infection was confirmed in both experimental groups. Histopathological lesions were evident in the respiratory tract of infected animals, although immunohistochemistry positivity was only detected in lungs and trachea of two H7N1-infected voles. Both HPAI viruses were transmitted by direct contact, and seroconversion was confirmed in 50% and 12.5% of the asymptomatic sentinels in the H7N1 and H5N1 groups, respectively. Interestingly, viable virus was isolated from lungs and nasal washes collected from contact sentinels of both groups. The present study demonstrated that two non-rodent adapted HPAI viruses caused asymptomatic infection in bank voles, which shed high amounts of the viruses and were able to infect contact voles. Further investigations are needed to determine whether bank voles could be involved as silent hosts in the transmission of HPAI viruses to other mammals and domestic poultry.

Bank vole

Seroconversion

Viral Shedding

Arvicolinae

10.1186/s13567-015-0184-1

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Hikui disease in nine koi carp (Cyprinus carpio): first description of a cutaneous perivascular wall tumour

Veterinary Dermatology (2016)

Rubina Sirri Tobia Pretto Francesco Montesi Valeria Berton Luciana Mandrioli

Background Hikui disease is a well known disfiguring disease of koi carp ( Cyprinus carpio ) primarily affecting fish with red pigmentation. It causes light orange to golden yellow, multifocal to coalescing raised patches, starting from the red cutaneous areas. Some cases respond to surgery or topical treatment, but recurrence is common. Objectives To describe the clinical and pathological presentation of Hikui disease and its cause. Animals Nine affected koi carp belonging to private hobbyists. Methods Eight fish underwent surgery or biopsy; one was euthanized. Tissues were submitted for histology, immunohistochemistry and transmission electron microscopy. Results Five fish showed typical lesions of Hikui disease, whereas four fish showed an atypical presentation characterized by focal or multifocal, oedematous, dark red cutaneous plaques or nodules. Histology showed unencapsulated, infiltrating and densely cellular neoplasms composed of spindle cells arranged in bundles, rows and whorls frequently centred on capillaries. Immunohistochemistry for smooth muscle actin labelled neoplastic cells in all cases. Ultrastructure showed neoplastic cells with slender cytoplasmic processes encircling the capillaries, a thin basal membrane and occasional plasmalemmal vesicles. Conclusions and clinical importance All of the data supported a neoplastic process producing perivascular wall tumours. Immunoreactivity to smooth muscle actin and the ultrastructural features were indicative of a pericyte origin (haemangiopericytoma). This is the first report dealing with Hikui disease that has achieved a conclusive diagnosis. The neoplastic nature of this condition suggests the potential usefulness of a surgical approach in the clinical management of less severe cases.

Histology

10.1111/vde.12338

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Citations (6)