Ina Chmelnitsky

Tel Aviv Sourasky Medical Center

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Yehuda Carmeli

Tel Aviv University

Ma'ayan Ben-Dalak

Tel Aviv Sourasky Medical Center

Amos Adler

Tel Aviv Sourasky Medical Center

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Tel Aviv Sourasky Medical Center

Tel Aviv University

Israel Ministry of Health

Academic College of Tel Aviv-Yafo

Oregon Medical Research Center

Manhattan Institute for Policy Research

Lindsay Unified School District

University of Pittsburgh

New York Proton Center

Communities In Schools of Orange County

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Effect of Resistance Mechanisms on the Inoculum Effect of Carbapenem in Klebsiella pneumoniae Isolates with Borderline Carbapenem Resistance

Antimicrobial Agents and Chemotherapy (2015)

Amos Adler Ma'ayan Ben-Dalak Ina Chmelnitsky Yehuda Carmeli

ABSTRACT We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolates exhibited a marked inoculum effect and were more resistant to the bactericidal effect of meropenem. This suggests that MIC measurements alone may not be sufficient in predicting the therapeutic efficacy of carbapenems against CPKP.

Carbapenem

Ertapenem

10.1128/aac.00533-15

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