Ildikó Pap

University of Szeged

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

György Pálfi

University of Szeged

Ildikó Szikossy

Hungarian Natural History Museum

Tamás Hajdu

Eötvös Loránd University

Albert Zink

Eurac Research

Mark Spigelman

Hebrew University of Jerusalem

Ron Pinhasi

University of Vienna

Helen D. Donoghue

University College London

Frank Maixner

Eurac Research

Tamás Szeniczey

Eötvös Loránd University

Olivia Cheronet

University of Vienna

Cooperative Institutions

University of Szeged

Hungarian Academy of Sciences

Eötvös Loránd University

Harvard University

Centre National de la Recherche Scientifique

Universidade de São Paulo

University of Vienna

Semmelweis University

Pennsylvania State University

Hungarian National Museum

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Efficacy of high dose systemic versus combined (systemic and intratympanic) corticosteroid therapy in idiopathic sudden sensorineural hearing loss: A prospective randomized trial and risk factor analysis

American Journal of Otolaryngology (2023)

Márta Kovács János Uzsaly Gréta Bodzai Ildikó Pap Balázs Lippai

The pathophysiology and the proper treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) are an ongoing subject of debate. Locally or systemic administered corticosteroids are the most accepted drugs of treatment in reference to ISSNHL (idiopathic sudden sensorineural hearing loss), however, no strong evidence nor guidelines regarding their effectiveness yet exists. In our prospective, randomized, controlled trial 78 participants were enrolled. Patients were randomly assigned based on the day of admission to two groups according to treatment: group SS (n = 43) received intravenous systemic methylprednisolone alone, and group CT (n = 35) received intratympanic dexamethasone + systemic methylprednisolone. The primary outcome was to compare the hearing outcomes between the treatment groups based on different, widely accepted categories (Siegel, Kanzaki, modified Siegel and PTA4 gain). In consideration of the secondary outcome, we examined the effect of the various risk factors on the hearing improvement. No differences were detected regarding hearing improvement between the two groups, based on any criteria [Siegel's criteria (p = 0.604); Kanzaki's criteria (p = 0.720); modified Siegel's criteria (p = 0.524) and PTA 4 gain (p = 0.569)]. However, several clinical factors such as vertigo (p = 0.039), or cardiovascular comorbidity (p = 0.02) and the severity of initial hearing loss (p = 0.033) were found to bear a significant impact upon the hearing outcome. To the best of our knowledge, this is the first randomized controlled trial comparing high dose systemic and combination corticosteroid therapy in ISSNHL patients. Our findings suggest coexisting cardiovascular comorbidity, vertigo and severity of the initial hearing loss may bear a significantly higher impact upon hearing improvement, than the additional intratympanic steroid administration. The presented trial was registered in the European Union Drug Regulating Authorities Clinical Trials Database (name: Combinated systemic and intratympanic steroid therapy in idiopathic sudden sensorineural hearing loss, No.: 2017-000658-20) and with the ethical approval of The National Institute of Pharmacy and Nutrition (OGYÉI) (protocol No.: 7621, on 2017.02.16.).

10.1016/j.amjoto.2023.104099

Cite

Citations (3)

Mitogenomic data indicate admixture components of Central-Inner Asian and Srubnaya origin in the conquering Hungarians

PLoS ONE (2018)

Endre Neparáczki Zoltán Maróti Tibor Kalmár Klaudia Kocsy Kitti Maár

It has been widely accepted that the Finno-Ugric Hungarian language, originated from proto Uralic people, was brought into the Carpathian Basin by the conquering Hungarians. From the middle of the 19th century this view prevailed against the deep-rooted Hungarian Hun tradition, maintained in folk memory as well as in Hungarian and foreign written medieval sources, which claimed that Hungarians were kinsfolk of the Huns. In order to shed light on the genetic origin of the Conquerors we sequenced 102 mitogenomes from early Conqueror cemeteries and compared them to sequences of all available databases. We applied novel population genetic algorithms, named Shared Haplogroup Distance and MITOMIX, to reveal past admixture of maternal lineages. Our results show that the Conquerors assembled from various nomadic groups of the Eurasian steppe. Population genetic results indicate that they had closest connection to the Onogur-Bulgar ancestors of Volga Tatars. Phylogenetic results reveal that more than one third of the Conqueror maternal lineages were derived from Central-Inner Asia and their most probable ultimate sources were the Asian Scythians and Asian Huns, giving support to the Hungarian Hun tradition. The rest of the lineages most likely originated from the Bronze Age Potapovka-Poltavka-Srubnaya cultures of the Pontic-Caspian steppe. Available data imply that the Conquerors did not have a major contribution to the gene pool of the Carpathian Basin.

Haplogroup

Steppe

Gene pool

Central Asia

10.1371/journal.pone.0205920

Cite

Citations (49)

DNA methylation profiling in mummified human remains from the eighteenth-century

Scientific Reports (2021)

Marco Schmidt Frank Maixner Gerhard Hotz Ildikó Pap Ildikó Szikossy

Abstract Reconstruction of ancient epigenomes by DNA methylation (DNAm) can shed light into the composition of cell types, disease states, and age at death. However, such analysis is hampered by impaired DNA quality and little is known how decomposition affects DNAm. In this study, we determined if EPIC Illumina BeadChip technology is applicable for specimens from mummies of the eighteenth century CE. Overall, the signal intensity on the microarray was extremely low, but for one of two samples we were able to detect characteristic DNAm signals in a subset of CG dinucleotides (CpGs), which were selected with a stringent processing pipeline. Using only these CpGs we could train epigenetic signatures with reference DNAm profiles of multiple tissues and our predictions matched the fact that the specimen was lung tissue from a 28-year-old woman. Thus, we provide proof of principle that Illumina BeadChips are applicable for DNAm profiling in ancient samples.

dNaM

Ancient DNA

10.1038/s41598-021-95021-7

Cite

Citations (4)

Sagittal suture morphological variation in human archaeological populations

The Anatomical Record (2021)

Olivia Cheronet Abigail Ash Alexandra Anders János Dani László Domboróczki

Abstract Cranial sutures join the many bones of the skull. They are therefore points of weakness and consequently subjected to the many mechanical stresses affecting the cranium. However, the way in which this impacts their morphological complexity remains unclear. We examine the intrinsic and extrinsic mechanisms of human sagittal sutures by quantifying the morphology from 107 individuals from archaeological populations spanning the Mesolithic to Middle ages, using standardized two‐dimensional photographs. Results show that the most important factor determining sutural complexity appears to be the position along the cranial vault from the junction with the coronal suture at its anterior‐most point to the junction with the lambdoid suture at its posterior‐most point. Conversely, factors such as age and lifeways show few trends in complexity, the most significant of which is a lower complexity in the sutures of Mesolithic individuals who consumed a tougher diet. The simple technique used in this study therefore allowed us to identify that, taken together, structural aspects play a more important role in defining the complexity of the human sagittal suture than extrinsic factors such as the mechanical forces imposed on the cranium by individuals' diet.

Variation (astronomy)

Sagittal suture

10.1002/ar.24627

Cite

Citations (4)

How does the relative wall thickness of human femora follow the biomechanical optima? An experimental study on mummies

Journal of Experimental Biology (2005)

Sándor Évinger Bence Suhai Balázs Bernáth Balázs Gerics Ildikó Pap

SUMMARY We studied how the ratio (K) of the internal:external diameter of human femora follows the biomechanical optima derived earlier by other researchers for marrow-filled tubular bones with circular cross section and minimum mass designed to withstand yield and fatigue, or stiffness, or bending fracture, or impact strengths. With evaluation of radiographs of 107 femora from 57 human mummies the values of K were measured. We found that Kposterior=0.498±0.085 for the posterior radiographic view, and Kmedial=0.589±0.070 for the medial view with Kmin=0.345 and Kmax=0.783. The theoretical optima for K depend on the ratio (Q) of the marrow:bone density. Accepting the assumption of earlier authors that Q=0.50, our data show that human femora are optimised to withstand bending fracture, or yield and fatigue strengths. There were no sex-, age- and length-specific differences in K, and the means of K of the right and left femora of individuals were statistically not significantly different. The biomechanical optimization for K of human femora is not finely tuned. Compared with fox femora, K of human femora follows the biomechanical optimum to a much lesser extent. Although the relative wall thickness W=1–K of human femora are optimised, the very low relative mass increment due to deviation of K from the optimum and the considerable intraspecific variance of K make it probable that an accurate optimization of the relative wall thickness is irrelevant in humans.

Human bone

10.1242/jeb.01475

Cite

Citations (5)

Correction: Mitogenomic data indicate admixture components of Central-Inner Asian and Srubnaya origin in the conquering Hungarians

PLoS ONE (2018)

Endre Neparáczki Zoltán Maróti Tibor Kalmár Klaudia Kocsy Kitti Maár

Multiple figure images are incorrectly switched.The image that appears as Fig 6 should be Fig 2, the image that appears as Fig 2 should be Fig 3, the image that appears as Fig 3 should be Fig 4, the image that appears as Fig 4 should be Fig 5, and the image that appears as Fig 5 should be Fig 6.The figure captions appear in the correct order.Please see the correct Figs 2-6 below.

10.1371/journal.pone.0208295

Cite

Citations (8)

Contribution of virtual 3D reconstruction and printing (VIRCOPAL®) to paleoanthropology: The case of the Neanderthal Subalyuk 2 child skull (Bukk Mountains, Hungary)

The 83rd Annual Meeting of the American Association of Physical Anthropologists, Calgary, Alberta Canada (2014)

Hélène Coqueugniot Anne-Marie Tillier György Pálfi Olivier Dutour Bruno Dutailly

Neanderthal

Paleoanthropology

Hominidae

Paleopathology

Homo erectus

Source

Cite

Citations (0)

Investigation of 2D dental tissue proportions in deciduous first and second upper molars of modern humans and Neanderthals

Cinzia Fornai Stefano Benazzi Carl Peter Bauer Ottmar Kullmer Jiřı́ Svoboda

Neanderthal

Source

Cite

Citations (0)

Skeletal evidence for morbidity and mortality in Copper Age samples from northeastern Hungary

International Journal of Osteoarchaeology (2008)

Douglas H. Ubelaker Ildikó Pap

Abstract Analysis of 183 human skeletons representing the Copper Age in northeastern Hungary indicates slightly less morbidity and mortality than found in previous studies of later Bronze Age and Iron Age samples from the same area. Mean adult age at death was 33.4 years for males and 32.9 years for females. Life table reconstruction revealed a life expectancy at birth of about 28 years, and at age 15 of about 17 years. Frequencies of dental hypoplasia (<1%) and carious lesions (2.3%) were relatively low. Comparisons of the Copper Age data reported here with previously published studies of later Bronze Age and Iron Age samples from the same area revealed little or no change in life expectancy at age 15, long bone diaphyseal circumference, estimated living stature, frequencies of dental hypoplasia, alveolar abscesses, tooth loss, adult porotic hyperostosis or trauma. Temporal increases were detected in life expectancy at birth, dental caries frequency, cribra orbitalia, subadult periosteal lesions and vertebral osteoarthritis. The study is part of a larger effort to examine long‐term temporal changes in skeletal samples from that region. Copyright © 2008 John Wiley & Sons, Ltd.

Tooth loss

Age groups

10.1002/oa.969

Cite

Citations (7)

RHEOLOGICAL PROPERTIES OF POLYMER BITUMEN BLENDS: BLACK AND COLE-COLE DIAGRAM PRESENTATION AND ANALYSIS

Jasna Djonlagić Ildikó Pap Juraj Jovanović

The viscoelastic properties of an unmodified bitumen and polymer-bitumen blends with 5% of SBS- or SBR-elastomer, as well as of SBS/SBR mixtures, were studied by dynamic mechanical analysis. Two different geometries, a parallel plate and a dynamic torsion rectangular, were used depending on the test temperature. The viscoelastic parameters of bitumen binders were shown using the so called Black Diagram which represents the complex shear modulus (G*) as a function of the phase angle (delta). This presentation of the rheological properties is advantageous since it results in a single curve, irrespective of experimental temperature and frequency. (A) For the covering abstract see IRRD 885061.

Shear modulus

Source

Cite

Citations (1)