Fangjie Han

Washington University in St. Louis

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Li Niu

Guangzhou University

Dongxue Han

Chinese Academy of Sciences

Zhishan Liang

Soochow University

Zhifang Wu

Shanxi Medical University

Dongfang Han

Guangzhou University

Mengjiao Dai

Jiangnan University

Wencai Fu

Guangzhou University

Julian Q. Zhou

Washington University in St. Louis

Jackson S. Turner

Washington University in St. Louis

Rachel M. Presti

Washington University in St. Louis

Cooperative Institutions

Washington University in St. Louis

Guangzhou University

Chinese Academy of Sciences

University of Missouri–St. Louis

Changchun Institute of Applied Chemistry

St. Jude Children's Research Hospital

University of Chinese Academy of Sciences

Children's Research Hospital

University School

Korea University

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Breathable and Skin-Mountable Strain Sensor with Tunable Stretchability, Sensitivity, and Linearity via Surface Strain Delocalization for Versatile Skin Activities’ Recognition

ACS Applied Materials & Interfaces (2018)

Zhongqian Song Weiyan Li Yu Bao Fangjie Han Lifang Gao

Metal film/elastomer-based strain sensors usually exhibit small rupture strain (<5%) because of the strain localization and necking effect of the metal film under tension. To achieve both high stretchability and wide linear region is still challenging for metal film-based strain sensors. Here, we propose a low-cost yet effective strategy for fabricating ultrathin, breathable, and skin-mountable strain sensors with high sensitivity (gauge factor from 7.2 to 474.8), high stretchability (up to 140%), and good linearity by regulating the surface strain delocalization in the metal film on elastomer substrate. On the basis of this phenomenon of strain delocalization, the sensitivity and linearity are further enhanced based on a novel diffraction-induced Au film with gradient thickness. Meanwhile, by means of the strain redistribution and Poisson effect, a novel biaxial strain sensor is designed for recognition of complex human motion. On the basis of the enhanced stretchability, linearity, skin-mountable, and breathable properties, the low-cost metal film-based strain sensors can be broadened as disposable wearables for human motion detection, emotional expression recognition, human interaction, and virtual reality.

Gauge factor

Linearity

Necking

Piezoresistive effect

Strain (injury)

Poisson's ratio

10.1021/acsami.8b14365

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Citations (75)

Mediating physicochemical properties and paclitaxel release of pH-responsive H-type multiblock copolymer self-assembly nanomicelles through epoxidation

Journal of Materials Chemistry B (2017)

Yan‐Ling Luo Xueyin Zhang Yuan Wang Fangjie Han Feng Xu

We focused on modulation of the physicochemical and biomedical properties of copolymer nanomicellesviaepoxidation, which provided significant improvements.

10.1039/c7tb00073a

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Citations (12)

SARS-CoV-2 Omicron boosting induces de novo B cell response in humans

bioRxiv (Cold Spring Harbor Laboratory) (2022)

Wafaa B. Alsoussi Sameer Kumar Malladi Julian Q. Zhou Zhuoming Liu Baoling Ying

The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in humans, but the emergence of highly infectious variants necessitated additional doses of these vaccines and the development of new variant-derived ones

Boosting

10.1101/2022.09.22.509040

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Citations (29)

mRNA-based influenza vaccine expands breadth of B cell response in humans

bioRxiv (Cold Spring Harbor Laboratory) (2024)

Hanover Matz Tae-Geun Yu Julian Q. Zhou Lowrey Peyton Anders Madsen

Eliciting broad and durable antibody responses against rapidly evolving pathogens like influenza viruses remains a formidable challenge

Antibody Repertoire

Memory B cell

10.1101/2024.10.10.617255

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Citations (1)

3D Tungsten Trioxide Nanosheets as Optoelectronic Materials for On-chip Quantification of Global Antioxidant Capacity

Chemical Research in Chinese Universities (2020)

Mengjiao Dai Weiguang Ma Fangjie Han Dongfang Han Lipeng Han

Tungsten trioxide

Photocurrent

10.1007/s40242-020-0234-8

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Citations (7)

Antigen-specific CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph node and blood following vaccination in humans

Research Square (Research Square) (2023)

Philip A. Mudd Nicholas Borcherding Wooseob Kim Michael Quinn Fangjie Han

Abstract SARS-CoV-2 infection and mRNA vaccination induce robust CD4⁺ T cell responses that are critical for the development of protective immunity. Here, we evaluated spike-specific CD4⁺ T cells in the blood and draining lymph node (dLN) of human subjects following BNT162b2 mRNA vaccination using single-cell transcriptomics. We analyze multiple spike-specific CD4⁺ T cell clonotypes, including novel clonotypes we define here using Trex, a new deep learning-based reverse epitope mapping method integrating single-cell T cell receptor (TCR) sequencing and transcriptomics to predict antigen-specificity. Human dLN spike-specific T follicular helper cells (T_FH) exhibited distinct phenotypes, including germinal center (GC)-T_FH and IL-10⁺ T_FH, that varied over time during the GC response. Paired TCR clonotype analysis revealed tissue-specific segregation of circulating and dLN clonotypes, despite numerous spike-specific clonotypes in each compartment. Analysis of a separate SARS-CoV-2 infection cohort revealed circulating spike-specific CD4⁺ T cell profiles distinct from those found following BNT162b2 vaccination. Our findings provide an atlas of human antigen-specific CD4⁺ T cell transcriptional phenotypes in the dLN and blood following vaccination or infection.

10.21203/rs.3.rs-3304466/v1

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A Recognition-Molecule-Free Photoelectrochemical Sensor Based on Ti3C2/TiO2 Heterostructure for Monitoring of Dopamine

Biosensors (2023)

Zhifang Wu Fangjie Han Tianqi Wang Liwei Guan Zhishan Liang

Herein, a novel, recognition-molecule-free electrode based on Ti3C2/TiO2 composites was synthesized using Ti3C2 as the Ti source and TiO2 in situ formed by oxidation on the Ti3C2 surface for the selective detection of dopamine (DA). The TiO2 in situ formed by oxidation on the Ti3C2 surface not only increased the catalytically active surface for DA binding but also accelerated the carrier transfer due to the coupling between TiO2 and Ti3C2, resulting in a better photoelectric response than pure TiO2. Through a series of experimental conditions optimization, the photocurrent signals obtained by the MT100 electrode were proportional to the DA concentration from 0.125 to 400 µM, with a detection limit estimated at 0.045 µM. We also monitored DA in human blood serum samples using the MT100 electrode. The results showed good recovery, demonstrating the promising use of the sensor for the analysis of DA in real samples.

Photocurrent

Photoelectric effect

10.3390/bios13050526

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Citations (3)

MoS₂/ZnO-Heterostructures-Based Label-Free, Visible-Light-Excited Photoelectrochemical Sensor for Sensitive and Selective Determination of Synthetic Antioxidant Propyl Gallate

Analytical Chemistry (2019)

Fangjie Han Zhongqian Song Mian Hasnain Nawaz Mengjiao Dai Dongfang Han

Propyl gallate (PG) as one of the important synthetic antioxidants is widely used in the prevention of oxidative deterioration of oils during processing and storage. Determination of PG has received extensive concern because of its possible toxic effects on human health. Herein, we report a photoelectrochemical (PEC) sensor based on ZnO nanorods and MoS2 flakes with a vertically constructed p–n heterojunction. In this system, the n-type ZnO and p-type MoS2 heterostructures exhibited much better optoelectronic behaviors than their individual materials. Under an open circuit potential (zero potential) and visible light excitation (470 nm), the PEC sensor exhibited extraordinary response for PG determination, as well as excellent anti-inference properties and good reproducibility. The PEC sensor showed a wide linear range from 1.25 × 10–7 to 1.47 × 10–3 mol L–1 with a detection limit as low as 1.2 × 10–8 mol L–1. MoS2/ZnO heterostructure with proper band level between MoS2 and ZnO could make the photogenerated electrons and holes separated more easily, which eventually results in great improvement of sensitivity. On the other hand, formation of a five membered chelating ring structure of Zn(II) with adjacent oxygen atoms of PG played significant roles for selective detection of PG. Moreover, the PEC sensor was successfully used for PG analysis in different samples of edible oils. It demonstrated the ability and reliability of the MoS2/ZnO-based PEC sensor for PG detection in real samples, which is beneficial for food quality monitoring and reducing the risk of overuse of PG in foods.

Nanorod

Visible spectrum

Gallate

10.1021/acs.analchem.9b01889

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Citations (107)

An Enzyme-Free Photoelectrochemical Sensor Platform for Ascorbic Acid Detection in Human Urine

Chemosensors (2022)

Zhengzheng Zhao Dongfang Han Ren Xiao Tianqi Wang Zhishan Liang

A novel enzyme-free photoelectrochemical (PEC) potential measurement system based on Dy-OSCN was designed for ascorbic acid (AA) detection. The separation and transmission of internal carriers were accelerated and the chemical properties became more stable under light excitation due to the regular microstructure of the prepared Dy-OSCN monocrystal. More importantly, the PEC potential method (OCPT, open circuit potential-time) used in this work was conducive to the reduction of photoelectric corrosion and less interference introduced during the detection process, which effectively ensured the repeatability and stability of the electrode. Under optimal conditions, the monocrystal successfully served as a matrix for the detection of AA, and the prepared PEC sensor exhibited a wide linear range from 7.94 × 10−6 mol/L to 1.113 × 10−2 mol/L and a sensitive detection limit of 3.35 μM. Practical human urine sample analysis further revealed the accuracy and feasibility of the Dy-OSCN-based PEC platform. It is expected that such a PEC sensor would provide a new way for rapid and non-invasive AA level assessment in human body constitution monitoring and lays a foundation for the further development of practical products.

Repeatability

Linear range

10.3390/chemosensors10070268

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Citations (6)

Prevalence of Antibodies against Neospora caninum in Père David's Deer (Elaphurus davidianus) in Beijing, China

Journal of Wildlife Diseases (2016)

Fangjie Han Yong Fu Changsheng Zhang Qun Liu Jianhai Xu

Neospora caninum is an apicomplexan protozoan and causes neuromuscular disorders in canids and abortions in cattle worldwide. We screened sera samples from 49 free-ranging Père David's deer ( Elaphurus davidianus ) in a nature reserve in Beijing, China, for antibodies against N. caninum using indirect fluorescence antibody tests and western blot tests. Antibodies were found in 27% of the deer. Western blot analysis revealed antibody reactivity against immunodominant N. caninum antigens of 16, 25, and 37 kDa in size together with other visible bands.

Neospora

10.7589/2015-07-193

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Citations (5)