ObjectiveTo explore the optimal dosage and method of bFGF application on surgical wound for accelerating its healing.MethodsLaceration wounds on the extremities of 63 patients were served as the target.The wounds were applied with three different doses of bFGF(75 Au/cm2,150 Au/cm2,300 Au/cm2) and with three application methods,i.e.once a day,twice a day and three times a day.Normal saline with 0.5% metronidazol was employed as control agents.The wound healing time in every group was recorded in days and compared with each other.ResultsWhen compared to each other,the wound healing time(day) was much shorter(P0.05) with bFGF application in dose of 75-300 Au/cm2.There were also obvious differences in wound healing time among groups treated with moistening of bGFG.Twice a day application could further shorten the wound healing time.ConclusionCompared to the dosage of the agent,the frequency and method of bGFG application seemed more important for its optimal effects.In view of the convenience,feasibility and economy,twice a day with moistening was recommended for clinical application.
