ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituted 1,4-DioxanesROBERT I. MELTZER, ARNOLD D. LEWIS, and ALEX FISCHMANCite this: J. Org. Chem. 1959, 24, 11, 1763–1766Publication Date (Print):November 1, 1959Publication History Published online1 May 2002Published inissue 1 November 1959https://pubs.acs.org/doi/10.1021/jo01093a038https://doi.org/10.1021/jo01093a038research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT8-Azasteroids. III.1 8-Azaestrogens and 8-Aza-19-norandrogensRichard E. Brown, David M. Lustgarten, R. John Stanaback, and Robert I. MeltzerCite this: J. Org. Chem. 1966, 31, 5, 1489–1495Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/jo01343a040https://doi.org/10.1021/jo01343a040research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of A New Class of Antishock Agents1aRichard E. Brown, David M. Lustgarten, R. John Stanaback, Melville W. Osborne, and Robert I. MeltzerCite this: J. Med. Chem. 1964, 7, 2, 232–235Publication Date (Print):March 1, 1964Publication History Published online1 May 2002Published inissue 1 March 1964https://pubs.acs.org/doi/10.1021/jm00332a024https://doi.org/10.1021/jm00332a024research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Forty-five different thyroxinc analogues have been compared to l-thyroxinc for their ability to decrease the thyroid collection of I131 in the rat. On a weight basis only 3,5,3′-triiodo-l-thyronine was found more effective than l-thyroxine. Compounds containing iodine were all capable of producing some inhibition roviding the dosage was adequate. THE dose of thyroid hormone, within limits, can be directly related to thyroidal uptake of I131 in experimental animals. This method has been used in the present report to assay the relative effectiveness of thyroxine analogues in blocking uptake of radioiodine in rats. Approximately 2,500 male rats of the Sprague-Dawley strain (Charles-River Breeding Laboratories, Boston, Massachusetts) ranging in weight between 75–125 gm. were used in this study. They were selected so that the average body weight of each group as essentially identical within each separate experiment.
The relative potencies of more than forty thyroxinc analogues and a soluble hog thyroglobulin extract were established in parallel goiter-prevention and calorigenic assays against the same thyroxine standard. By both methods of assay twelve of the preparations had activities ranging from 5% to 800% of that of thyroxine. The activities, if any, of the remaining analogues were less than 3% of that of the standard. Analysis of area-under-curve and speed of response in calorigenic assays indicated that all the active analogues and soluble thyroglobulin were qualitatively similar with respect to this parameter of thyromimetic function in normal adult male rats. Thyroglobulin was characteristically more active than expected when its potency, relative to thyroxine, was calculated on the assumption that its thyronine-bound iodine, as determined by the Blau, 1935, procedure, was in the form of thyroxine.
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