Lucia Battistini

University of Parma

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Co-Authors

Franca Zanardi

University of Parma

162

Gloria Rassu

Istituto di Chimica Biomolecolare

127

Giovanni Casiraghi

University of Parma

120

Claudio Curti

University of Parma

116

Andrea Sartori

University of Parma

Giorgio Pelosi

University of Parma

Vincenzo Zambrano

Istituto di Chimica Biomolecolare

Luigi Pinna

University of Sassari

Luciana Auzzas

University of Sassari

Paola Burreddu

Istituto di Chimica Biomolecolare

Cooperative Institutions

University of Parma

University of Milan

University of Florence

University of Naples Federico II

University of Turin

Istituti di Ricovero e Cura a Carattere Scientifico

Istituto di Chimica Biomolecolare

University of Campania "Luigi Vanvitelli"

University of Sassari

National Research Council

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Targeting αvβ3 Integrin: Design and Applications of Mono- and Multifunctional RGD-Based Peptides and Semipeptides

Current Medicinal Chemistry (2010)

Luciana Auzzas Franca Zanardi Lucia Battistini Paola Burreddu Paola Carta

The outstanding physio-pathological role played by integrin receptors in living subjects motivates the enormous interest shown by scientists worldwide for this topic. More than twenty years of research has spanned across the structural and functional elucidation of these proteins and over their antagonism-based biomedical applications. The proof-of concept stage, aimed at identifying potent inhibitors, covered a decade of studies, and paved the way for a more advanced era of research where these antagonist molecules were thrown into the deep end of applicative studies. This review intends to summarize the major efforts conducted thus far and focuses on the design, synthesis and biomedical applications of cyclic RGD-containing alpha(v)beta(3) integrin antagonists, in both their small and macromolecular formats. In particular, Chapters 1 and 2 offer a comprehensive outlook on the rational basis for the design of integrin inhibitors, Chapter 3 chronicles the biological and medical applications of monofunctional RGD integrin ligands both in their monomeric and multimeric asset, and Chapter 4 illustrates the potential of RGD-based multifunctional systems in molecular medicine.

Rational design

10.2174/092986710790936301

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Citations (98)

Catalytic, Enantioselective Vinylogous Mukaiyama Aldol Reaction of Furan‐Based Dienoxy Silanes: A Chemodivergent Approach to γ‐Valerolactone Flavan‐3‐ol Metabolites and δ‐Lactone Analogues

Advanced Synthesis & Catalysis (2015)

Claudio Curti Nicoletta Brindani Lucia Battistini Andrea Sartori Giorgio Pelosi

Abstract The asymmetric synthesis of a set of hydroxyphenyl γ‐valerolactones was achieved starting from 2‐silyloxyfuran and alkoxy‐substituted benzaldehydes as common precursors. Key synthesis steps included an enantioselective vinylogous Mukaiyama aldol reaction and a Barton–McCombie deoxygenation. Five enantioenriched γ‐valerolactone targets were obtained in 5–6 steps, 18–63% overall yields and 82–98 % ee , paving the way for the straightforward entry to this class of biologically effective and poorly available flavan‐3‐ol metabolites. In parallel, an unprecedented one‐pot reductive ring expansion process was fortuitously discovered, yielding racemic δ‐lactone analogues from phenolic butanolide precursors. magnified image

Deoxygenation

Aldol reaction

Furan

Silanes

10.1002/adsc.201500705

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Citations (42)

ChemInform Abstract: Asymmetric Access to Functional, Structurally Diverse Molecules Exploiting Five‐Membered Heterocyclic Silyloxy Dienes

ChemInform (1999)

Giovanni Casiraghi Gloria Rassu Franca Zanardi Lucia Battistini

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.199928298

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Citations (0)

Cell-targeted c(AmpRGD)-sunitinib molecular conjugates impair tumor growth of melanoma

Cancer Letters (2019)

Francesca Bianchini Elisabetta Portioli Francesca Ferlenghi Federica Vacondio Elena Andreucci

Internalization

10.1016/j.canlet.2018.12.021

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Citations (29)

Diastereoselective synthesis of a novel lactam peptidomimetic exploiting vinylogous Mannich addition of 2-silyloxyfuran reagents

Tetrahedron Asymmetry (1999)

Lucia Battistini Gloria Rassu Luigi Pinna Franca Zanardi Giovanni Casiraghi

Peptidomimetic

Lactam

Imine

Mannich reaction

Furan

10.1016/s0957-4166(99)00051-8

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Citations (28)

ChemInform Abstract: Exploring the Vinylogous Reactivity of Cyclohexenylidene Malononitriles: Switchable Regioselectivity in the Organocatalytic Asymmetric Addition to Enals Giving Highly Enantioenriched Carbabicyclic Structures.

ChemInform (2015)

Luca Dell’Amico Gloria Rassu Vincenzo Zambrano Andrea Sartori Claudio Curti

Abstract A two‐step, one‐pot sequence under chiral amine—NHC catalysis allows the approach to spiro[4.5]decanone structures in a diastereoselective manner with high e.e.

Reactivity

Sequence (biology)

10.1002/chin.201509070

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Citations (0)

ChemInform Abstract: Lewis Acid Assisted Vinylogous Mannich and Mukaiyama Aldol Reactions: A Route to Densely Hydroxylated Indolizidine Alkaloid Analogues.

ChemInform (1999)

Gloria Rassu Paola Carta Luigi Pinna Lucia Battistini Franca Zanardi

Indolizidine

Aldol reaction

10.1002/chin.199936258

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Citations (1)

CCDC 834893: Experimental Crystal Structure Determination

The Cambridge Structural Database (2012)

Andrea Sartori Luca Dell’Amico Claudio Curti Lucia Battistini Giorgio Pelosi

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccx0s1q

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Citations (0)

CCDC 757775: Experimental Crystal Structure Determination

The Cambridge Structural Database (2011)

Claudio Curti Beatrice Ranieri Lucia Battistini Gloria Rassu Vincenzo Zambrano

10.5517/cctfjc3

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CCDC 834895: Experimental Crystal Structure Determination

The Cambridge Structural Database (2012)

Andrea Sartori Luca Dell’Amico Claudio Curti Lucia Battistini Giorgio Pelosi

10.5517/ccx0s3s

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Citations (0)