Kazuko Hamanaka

Onomichi General Hospital

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Naotika Toki

Hiroshima University

Sumiyoshi Takasugi

Hiroshima University

Kenji Ishizu

Hiroshima University

Grete Laurberg

Aalborg University

J. Lauharanta

Helsinki University Hospital

U. Lube

M. Boitard

Satoshi Dekio

Shimane University

A Lassus

Hôpital Bichat-Claude-Bernard

Yuji Horiguchi

Noguchi Hospital

Cooperative Institutions

Hiroshima University

University of Copenhagen

The University of Tokyo

Futaba (Japan)

Shimane University

Kyoto University

Centre Hospitalier Universitaire de Grenoble

Marselisborgcentret

Osaka University

GTx (United States)

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Isolation of an Elastase-Like Enzyme from Skin Lesions with Sweet’s Syndrome

Dermatology (1983)

Kazuko Hamanaka Kenji Ishizu Sumiyoshi Takasugi Naotika Toki

In the present study, an elastase-like enzyme which possessed elastolytic, proteolytic and N<sup>α</sup>-Acetyl-<i>L</i>-tyrosine ethyl ester hydrolytic activities was extracted from skin lesions with Sweet’s syndrome.

Isolation

Sweet's syndrome

10.1159/000249864

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Citations (6)

A Case of Psoriasis Vulgaris with Recurrent Uveitis.

The Nishinihon Journal of Dermatology (1993)

Shigeki Sato Kazuko Hamanaka Eishin Morita Shoso Yamamoto

52歳女子。尋常性乾癬に発熱, 関節炎, ぶどう膜炎を併発した1例を報告した。ライター病にみられる尿道炎, 粘膜病変は認めなかった。コルヒチン, ステロイド内服により治療を行ったが, ぶどう膜炎の再発を繰り返したためサイクロスポリンAを投与したところ軽快した。HLA抗原系ではB27は検出されず, ベーチェット病患者で高頻度にみられるとされるB51が陽性であった。

10.2336/nishinihonhifu.55.1048

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Citations (2)

Secondary Syphilis of the Pharynx and Larynx

Practica oto-rhino-laryngologica Suppl (1988)

Akira Nagasawa Michinori Kurokawa Kazuko Hamanaka Kenji Morita

A 47-year-old male with secondary syphilis is reported. He had been misdiagnosed as having laryngeal carcinoma (squamous cell carcinoma) by punch out biopsy of right arytenoid.He had no symptom of the throat, but was followed up for multiple leukoplakia of the pharynx and larynx, which was pointed out at another clinic and he recieved a biopsy. Then he was referred to our clinic for treatment. Serum syphilitic reaction at the admission revealed titers of 1: 64 by the glass plate method,1: 128 by the agglutination, and 1: 1280 by TPHA. He had no abnormality in the genitals or body surface.Of 13 syphilis cases (J an,1985-May,1986; Onomichi General Hospital),7patients have no symptomatic. We concluded that nonsymptomatic syphilis, on the increase, should be discovered through various methods, such as pre-operative examination, other various medical examinations, and doctors' intensive observations.

Throat

10.5631/jibirinsuppl1986.1988.supplement27_126

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Statistic Observation of Inpatients with Herpes Zoster.

The Nishinihon Journal of Dermatology (1992)

WATAEDA Koji Kazuko Hamanaka Atsuko Takahashi Kenji Morita

昭和63年1月より平成1年12月までの2年間に尾道総合病院皮膚科に入院した帯状疱疹患者116例について統計的観察を行った。入院患者総数に対する帯状疱疹患者の占める割合は31.0%であり, 季節的には冬と秋に比較的多かった。年齢別分布では高齢者に多く60歳代にピークを示し, 性別では女子に多かった。発症部位は顔面·頭部が最も多く, 左右差はみとめられなかった。基礎疾患を有するものは45.7%に及び, 高血圧, 癌, 肝疾患, 心疾患, 糖尿病の順に多かった。疼痛の強い期間は加齢に伴い延長し, 部位的には腹部, 上肢·胸部に発症したものに長い傾向がみとめられた。汎発化は37.1%にみとめ, より高齢者の男性に多く, 疼痛の強い期間はより遷延する傾向にあった。水痘—帯状疱疹ウイルスに対する補体結合反応抗体価は発症後2週間以内では汎発化との間に相関関係はみとめられなかったが, 発症後2週間以上を経て検索した場合には汎発例では著明に高値を示した。抗体価と疼痛の強い期間との間には, 相関関係はみとめられなかった。

Statistic

10.2336/nishinihonhifu.54.322

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EFFECT OF PLANT SH‐PROTEASE ON HUMAN POLYMORPHONUCLEAR LEUKOCYTE GRANULE ELASTASE

The Journal of Dermatology (1984)

Kazuko Hamanaka Naotika Toki Sumiyoshi Takasugi Hiroyuki Sumi

ABSTRACT In the present study, attempts were made to examine the effects of plant SH‐protease on human polymorphonuclear leukocyte granule elastase. S‐2484 amidolytic activity in extracted solution using 0.1% Triton X‐100 was remarkably higher than in the solution without Triton X‐100. The authors confirmed the possibility that the presence of solvents such as Triton X‐100 might be required for extraction of elastase from the granule membrane. It was also confirmed that ficin and papain inhibited extraction of elastase from the granule membrane by Triton X‐100, and that SH‐protease can inhibit S‐2484 amidolytic and Congo red‐elastinolytic activities of the released elastase. However, it is not clear whether SH‐protease inhibits the release of proelastase from the granule membrane or inhibits activation of released proelastase to elastase. The authors assume that there may be competitive inhibition between SH‐protease and elastase against the substrate.

Granule (geology)

10.1111/j.1346-8138.1984.tb01519.x

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Announcements

Dermatology (1983)

Razzaque Ahmed Ronald L. Moy David Chia Eugene V. Barnett Kazuko Hamanaka

10.1159/000249874

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Book Reviews

Dermatology (1983)

Razzaque Ahmed Ronald L. Moy David Chia Eugene V. Barnett Kazuko Hamanaka

10.1159/000249873

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Isolation of an elastase-like enzyme from skin lesions with Sweet's syndrome

Ensho (1981)

Kazuko Hamanaka Kenji Ishizu Naotika Toki Sumiyoshi Takasugi

Isolation

Sweet's syndrome

10.2492/jsir1981.2.4_357

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Citations (0)

Statistical Study of Impetigo Contagiosa in the Last Three Years

The Nishinihon Journal of Dermatology (1980)

Satoshi Dekio Yoshiko Maehama Reiko Yamasaki Kazuko Hamanaka S Ikeda

Impetigo contagiosa was studied statistically in 1977-1979 with regard to the relation between ages and months of the outbreak, and weather conditions. Species and strains of bacteria isolated from the lesions and their sensitivities to antibiotics were also determined. The main affected ages were one to five, and the disease broke out most in July and August. A high temperatures with long exposure to the sun was considered to stimulate the occurrence of the disease. Staphylococcus aureus was predominantly isolated from the lesions. The order of the sensitivities of the isolated Staphylococcus aureus to antibiotics was MDIPC, CEX, GM>CP>TC>ABPC, AMPC>EM. The sensitivities to MDIPC, CEX and GM were of 100% or nearly 100%, and the sensitivity to EM was about of 50% or less.

Impetigo

10.2336/nishinihonhifu.42.665

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Citations (1)

Cysteine protease inhibitors isolated from human malignant melanoma tissue.

PubMed (1985)

Hiroshi Tsushima Hirofumi Sumi Kazuko Hamanaka Naotika Toki Hiroshi Sato

Sephadex

Sepharose

Cysteine protease

Molecular mass

Cysteine Proteinase Inhibitors

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Citations (6)