John R. Stavorski

United States Military Academy

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Effects of Bethanechol, Metoclopramide, and Domperidone on Antral Contractions in Cats and Dogs

Digestion (1983)

Allen W. Mangel John R. Stavorski Robert G. Pendleton

The effects of bethanechol, metoclopramide, and domperidone were examined on antral contractions in anesthetized dogs and cats. Bethanechol and metoclopramide were found to increase contractility in both the dog and cat, while domperidone did not stimulate contractions in the cat but was effective in the dog. With domperidone, unlike bethanechol and metoclopramide, changes in mean blood pressure were not produced. Our results indicate that all three of the agents examined can stimulate contractions in the antrum, but the choice of animal model is critical for the proper evaluation of the compounds.

Bethanechol

Domperidone

Metoclopramide

Dopamine antagonist

Contractility

10.1159/000198989

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Citations (14)

Contents, Vol. 28, 1983

Digestion (1983)

Allen W. Mangel John R. Stavorski Robert G. Pendleton J. Pirotte D. El Allaf

10.1159/000198988

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Announcement

Digestion (1983)

Allen W. Mangel John R. Stavorski Robert G. Pendleton Jean Pirotte Dia El Allaf

10.1159/000198997

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Author Index, Vol. 28, 1983

Digestion (1983)

Allen W. Mangel John R. Stavorski Robert G. Pendleton Jean Pirotte D. El Allaf

10.1159/000198998

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Evidence for differing leukotriene receptors in gastric mucosa

European Journal of Pharmacology (1986)

Robert G. Pendleton John R. Stavorski

10.1016/0014-2999(86)90041-5

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Citations (25)

Letters to the Editor

Digestion (1983)

Allen W. Mangel John R. Stavorski Robert G. Pendleton Jean Pirotte D. El Allaf

Sir, In their report on a patient with dihydral azine hepatitis, Pariente et al. [1] quoted 3 cases from the literature, claiming to present a 'review o f the literature'.They have failed, however, to mention at least 22 further cases reported by German authors.We have seen 2 patients [2], probably too recently to be noted by Pariente et al., but Roschlau et al. [3] and Roschlau [4] observed and published 20 cases o f dihydralazine hepatotoxicity.The purpose o f our letter is to draw the attention o f an international readership to these further reports which indicate a rather frequent com plication of dihydralazine therapy.

10.1159/000198996

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