J.P. Dillon

University of Liverpool

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L. Ranganath

University of Liverpool

James A. Gallagher

University of Liverpool

Peter J. Wilson

University of Liverpool

J.A. Gallagher

University of Liverpool

J.A. Gallagher

University of Liverpool

William D. Fraser

University of East Anglia

Katherine M. Buckley

Auburn University

Alison Gartland

University of Sheffield

Milad Khedr

Royal Liverpool University Hospital

Anna M. Milan

University of Liverpool

Cooperative Institutions

University of Liverpool

Royal Liverpool University Hospital

University of Southampton

MRC Lifecourse Epidemiology Unit

Imperial College London

McGill University

Royal Manchester Children's Hospital

Aintree University Hospitals NHS Foundation Trust

Royal Liverpool and Broadgreen University Hospital NHS Trust

University of Manchester

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Raman spectroscopy can non-invasively distinguish between ochronotic and non-ochronotic cartilage

Osteoarthritis and Cartilage (2018)

Adam Taylor D. Jenks Vishnu Kammath Brendan P. Norman J.P. Dillon

Ochronosis

Alkaptonuria

Homogentisic acid

10.1016/j.joca.2018.02.227

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Citations (2)

Regulation of epidermal homeostasis through P2Y₂receptors

British Journal of Pharmacology (1999)

C. Jane Dixon W.B. Bowler Amanda Littlewood‐Evans J.P. Dillon Graeme Bilbe

Previous studies have indicated a role for extracellular ATP in the regulation of epidermal homeostasis. Here we have investigated the expression of P2Y 2 receptors by human keratinocytes, the cells which comprise the epidermis. Reverse transcriptase‐polymerase chain reaction (RT–PCR) revealed expression of mRNA for the G‐protein‐coupled, P2Y 2 receptor in primary cultured human keratinocytes. In situ hybridization studies of skin sections revealed that P2Y 2 receptor transcripts were expressed in the native tissue. These studies demonstrated a striking pattern of localization of P2Y 2 receptor transcripts to the basal layer of the epidermis, the site of cell proliferation. Increases in intracellular free Ca 2+ concentration ([Ca 2+ ] i ) in keratinocytes stimulated with ATP or UTP demonstrated the presence of functional P2Y receptors. In proliferation studies based on the incorporation of bromodeoxyuridine (BrdU), ATP, UTP and ATPγS were found to stimulate the proliferation of keratinocytes. Using a real‐time firefly luciferase and luciferin assay we have shown that under static conditions cultured human keratinocytes release ATP. These findings indicate that P2Y 2 receptors play a major role in epidermal homeostasis, and may provide novel targets for therapy of proliferative disorders of the epidermis, including psoriasis. British Journal of Pharmacology (1999) 127 , 1680–1686; doi: 10.1038/sj.bjp.0702653

Epidermis (zoology)

P2Y receptor

Bromodeoxyuridine

Homeostasis

10.1038/sj.bjp.0702653

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Citations (109)

Increased production of PTHrP by osteoblasts derived from four patients with McCune Albright syndrome

Bone (1995)

Claire Walsh J.P. Dillon Benjamin H. Durham W.D. Fraser J.A. Gallagher

McCune–Albright syndrome

10.1016/8756-3282(96)87809-4

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Citations (1)

Low dose PTH, insufficient to induce cyclic AMP or C-fos, stimulates an anabolic gene response in human osteoblasts in vitro

Bone (2006)

Katherine M. Buckley J.P. Dillon Belinda Chan Alison Gartland W.D. Fraser

10.1016/j.bone.2006.01.074

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Collagen VI is present in bone and its expression is inversely correlated with maturity

Bone (2009)

Peter J. Wilson B Wlodarski J.P. Dillon Simon C. Wagstaff William D. Fraser

Viability assay

10.1016/j.bone.2009.03.465

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Type VI collagen plays a major role in adhesion of osteoblastic cells

Bone (2010)

Peter J. Wilson J.P. Dillon J.A. Gallagher Victoria J. Waring-Green

Type I collagen

10.1016/j.bone.2010.04.304

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Time course and mechanisms of the synergistic activation of osteoblastic cells by extracelluar ATP and PTH

Bone (2010)

Alistair P. Bond Peter J. Wilson J.P. Dillon J.A. Gallagher

10.1016/j.bone.2010.04.252

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ATP-Stimulated ATP release and metabolic acid production:-regulating life and death decisions in articular chondrocytes

Osteoarthritis and Cartilage (2013)

J.P. Dillon Giulia Vindigni John A. Collins Peter J. Wilson L. Ranganath

P2 receptor

10.1016/j.joca.2013.02.233

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Citations (2)

On fragmenting, densely mineralised acellular protrusions into articular cartilage and their possible role in osteoarthritis

Journal of Anatomy (2014)

A. Boyde Graham Davis David Mills Tomáš Zikmund Timothy M. Cox

Abstract High density mineralised protrusions ( HDMP ) from the tidemark mineralising front into hyaline articular cartilage ( HAC ) were first described in T horoughbred racehorse fetlock joints and later in I celandic horse hock joints. We now report them in human material. Whole femoral heads removed at operation for joint replacement or from dissection room cadavers were imaged using magnetic resonance imaging ( MRI) dual echo steady state at 0.23 mm resolution, then 26‐μm resolution high contrast X ‐ray microtomography, sectioned and embedded in polymethylmethacrylate, blocks cut and polished and re‐imaged with 6‐μm resolution X ‐ray microtomography. Tissue mineralisation density was imaged using backscattered electron SEM ( BSE SEM ) at 20 kV with uncoated samples. HAC histology was studied by BSE SEM after staining block faces with ammonium triiodide solution. HDMP arise via the extrusion of an unknown mineralisable matrix into clefts in HAC , a process of acellular dystrophic calcification. Their formation may be an extension of a crack self‐healing mechanism found in bone and articular calcified cartilage . Mineral concentration exceeds that of articular calcified cartilage and is not uniform. It is probable that they have not been reported previously because they are removed by decalcification with standard protocols. Mineral phase morphology frequently shows the agglomeration of many fine particles into larger concretions. HDMP are surrounded by HAC , are brittle, and show fault lines within them. Dense fragments found within damaged HAC could make a significant contribution to joint destruction. At least larger HDMP can be detected with the best MRI imaging ex vivo .

X-ray microtomography

Fibrocartilage

10.1111/joa.12226

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Citations (32)

Distribution of an extracellular matrix antigen recognized by monoclonal antibody CS-GC3, in bone, cartilage, bone tumors, and soft tissue

Bone (1986)

C.E. Sheard J.P. Dillon N. Billingham L. G. Bobrow J. Pringle

Hydroxyproline

10.1016/8756-3282(86)90245-0

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Citations (0)