ОС

О. С. Коншина

Research Institute of Influenza

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МК

М. К. Ерофеева

Research Institute of Influenza

Marina Stukova

Research Institute of Influenza

I. Yu. Nikonorov

Research Institute of Influenza

ВЛ

В. Л. Максакова

Research Institute of Influenza

ОИ

О. И. Киселев

Research Institute of Influenza

Maria Nikolaevna Dmitrieva

Ryazan State Medical University named after Academician I.P. Pavlov

АА

А. А. Соминина

Research Institute of Influenza

Sologub Tv

Ministry of Health of the Russian Federation

Andrey B. Komissarov

Research Institute of Influenza

Elena Grigorieva

Institute of Experimental Medicine

Cooperative Institutions

Research Institute of Influenza

Ministry of Health of the Russian Federation

Russian Academy of Sciences

Institute of Experimental Medicine

Academy of Medical Sciences

Czech Academy of Sciences, Institute of Experimental Medicine

Saint Petersburg State Pediatric Medical University

Peter the Great St. Petersburg Polytechnic University

Kurchatov Institute

St Petersburg University

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Мутации в генах человека, повышающие риск тяжелого течения гриппозной инфекции

Microbiology Independent Research Journal (MIR Journal) (2015)

О. И. Киселев Andrey B. Komissarov О. С. Коншина Maria Nikolaevna Dmitrieva Э. Г. Деева

Система генетического контроля реакции врожденного иммунитета на гриппозную инфекцию и функции генов позволяет вести разработку системного лечения гриппа с ориентацией на фенотипические проявления мутаций с учетом наследственной предрасположенности индивида к тяжелому течению заболевания и/или развитию осложнений.

10.18527/2500-2236-2015-2-1-1-9

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Role of biobanks in the study of population immunity

Journal Infectology (2018)

О. С. Коншина Eropkin MIu I. Yu. Nikonorov M. G. Pozdnyakova

Review focuses on estimation of population immunity and effectiveness of vaccination against socially significant influenza infection. Long-term observations of the population immunity, including post-vaccine seroprevalence to influenza are an important component of surveillance. The possibility of use of systems of biological banks (biobanks) in these investigations is of great interest. The data on the principles of biobanks design in the world, the scope of their application, the present state of the industry are described. The information about collections of infectious diseases agents is presented. Suggestions to build a network of biobanks in the Russian Federation and its implementation in the system of epidemiological influenza surveillance are formed. The biobanks filling by samples, principles of selection of donors biological specimens, methods of laboratory research are discussed.

Scope (computer science)

10.22625/2072-6732-2018-10-2-39-47

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OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)

Anatoly Naykhin Svetlana Donina Igor Losev Galina Petukhova Daniil Korenkov

Attenuated vaccine

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OMOLOGICAL AND HETEROLOGICAL ANTIBODY AND T CELL IMMUNE RESPONSES TO LIVE ATTENUATED INFLUENZA VACCINE A (H5N2) AND A (H7N3)

Medical Immunology (Russia) (2015)

Anatoly Naykhin Svetlana Donina Igor Losev Galina Petukhova Daniil Korenkov

From the beginning of 21 th century outbreaks of H5, H7 and H9 avian flu are registered from time to time. These viruses are considered as one of the possible causes of the next pandemia. The development of avian influenza vaccines is one of the WHO priorities. The aim of this work was to study antibody and cellular immune responses to avian A (H5N2) and A (H7N3) live attenuated influenza vaccines (LAIVs). We examined serum antibodies (HAI assay, microneutralization assay, ELISA), local antibodies (ELISA) and virus-specific CD4 + and CD8 + central memory and effector memory T cells. Two doses vaccination of healthy volunteers with A (H5N2) and A (H7N3) LAIVs induced homological antibody and cellular immune responses (i. e. serum and local antibody conversions, virus-specific memory T cell growth). These vaccines also stimulated heterological immunity (heterological serum and local antibodies and T cells). Heterological immune response intensity depended on antigenic structure of vaccine strain and heterological virus, particularly on HA type.

Original antigenic sin

10.15789/1563-0625-2015-1-59-70

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Protective Properties of Inactivated Virosomal Influenza Vaccine

Procedia in Vaccinology (2014)

М. К. Ерофеева I.J. Nickonorov В. Л. Максакова Marina Stukova О. С. Коншина

Currently, application of new technological solutions for the implementation of strategies for improving influenza vaccines are up to date and modern. In this study, we present data obtained in the evaluation of the safety and immunogenicity of the new Russian (national) split seasonal inactivated influenza vaccine ULTRIKS in comparison with a commercial vaccine VAXIGRIP in various age groups.

Seasonal influenza

Inactivated vaccine

10.1016/j.provac.2014.07.005

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PREVENTIVE VACCINATION AGAINST INFLUENZA TODAY

Meditsinskiy sovet = Medical Council (2016)

О. С. Коншина M. K. YEROFEYEVA Alexandra Nikiforova В. Л. Максакова

Influenza vaccination is the most strategically justifiable way to protect against influenza which allows toprevent influenza infection and its serious complications, as well as mitigate the impact of influenza epidemics. The main challenge in the fight against influenza is that influenza vaccine needs to be renewed annually due to year-to-year variability of influenza viruses. In recent years, the idea of a single vaccine against all A subtypes of the influenza virus has been actively studied.

Seasonal influenza

10.21518/2079-701x-2016-07-86-89

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Epidemiological Peculiarities of the Flu Epidemic of 2016 in St. Petersburg

Epidemiology and Vaccinal Prevention (2016)

Л. С. Карпова Н. М. Поповцева T. P. Stolyarova K. A. Stolyarov О. С. Коншина

To identify the peculiarities of manifestation of epidemic process of influenza in 2016, and causes high morbidity and mortality in St. Petersburg, a comparative analysis of the incidence of influenza and acute respiratory viral infections, hospitalization and mortality in children and adults during the epidemic of 2016 in St. Petersburg and other 58 the observed cities of the Russian Federation. The epidemic of 2016 in St. Petersburg from other cities were characterized by a greater intensity: the duration of the epidemic; the incidence of the population on the peak (at 1.9 and 1.3%), within the boundaries of the epidemic in the city (7.7 and 5.4%) and the country (11.9 and 9,6%); shares admitted to hospital with a diagnosis of «influenza» among the whole population (17.1 and 14,0%); greater mortality from influenza among the whole population (3.3 tims), persons 15 - 64 (in 3 times) and 65 years and older (2.8 times). The low level of population immunity in Saint-Petersburg in the before the epidemic period and lower frequency of hospitalization of patients with influenza and ARVI among the population as a whole (2.4% and 3.6 percent), particularly children and persons over 65 years of age (2 times), could be the cause of high morbidity and mortality from influenza in St. Petersburg.

Saint petersburg

St petersburg

10.31631/2073-3046-2016-15-4-13-21

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Графическое отображение иммуногенной активности вакцинных штаммов вирусов гриппа

Эпидемиология и вакцинопрофилактика (2014)

В С Вакин Е М Войцеховская Aleksandra Vasileva Е. В. Кузнецова О. С. Коншина

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Problems of vaccine prophylaxis of influenza in pregnant women

Epidemiology and Infectious Diseases (2016)

В. Л. Максакова О. С. Коншина М. К. Ерофеева И. И. Токин

Pregnant women are at high risk for the adverse course of respiratory diseases, among which the influenza is the one of the leading infections, of ten finishing tragically for most pregnant and her offspring. Due to the disproportionately high morbidity, mortality and adverse outcomes of pregnancy after influenza virus infection, pregnant females are classified as a priority group for vaccination. Immunization with inactivated influenza vaccine is one of the most important strategy to prevent both of influenza infection, its severe complications, and mitigating of the effects of the epidemic of influenza. There was accumulated sufficient evidence demonstrating that the vaccine promotes the diminution of clinical manifestations of influenza infection in pregnant women, as well, has a positive effect on the health of the newborns due to the active transport of maternal antibodies. In the review there are presented data on the safety, high immunogenicity and clinical efficacy of vaccination against influenza as for pregnant women as well for infants.

10.17816/eid40874

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POPULATION IMMUNITY TO INFLUENZA VIRUS A(H1N1)pdm09, A(H3N2) AND B IN THE ADULT POPULATION OF THE RUSSIAN FEDERATION LONG-TERM RESEARCH RESULTS

Russian Journal of Infection and Immunity (2017)

О. С. Коншина А. А. Соминина Elizaveta Smorodintseva K. A. Stolyarov I. Yu. Nikonorov

Analysis of changes in the population immunity level in adults for more than 20 Russian cities, collaborating with the Federal Center for Influenza, to circulating influenza viruses A(H1N1)pdm09, A(H3N2) and B in the period from 2009 to 2015 performed. By the beginning of the pandemic (October 2009) the population of Russia was almost seronegative to influenza A(H1N1)pdm09 virus. After the pandemia first wave mean geometric titers (GMT)s of antibodies to the pandemic virus increased by 2.6 times, after the second one by 4.9 times in comparison with initial GMT (1:5.5). A consistent increase in GMTs antibody after each of the subsequent seasons of active circulation of pandemic virus was observed reaching the maximum (1:41) by April 2013, after the next epidemic caused by this virus. The proportion of people with protective antibody titers in October 2009 to already started circulating influenza A(H1N1)pdm09 virus was 8.2%, to influenza A(H3N2) virus — 58.3%, and influenza B virus — 59.7%. Level of population immunity in adults to seasonal influenza A(H3N2) and B viruses throughout the observed period was significantly higher than to influenza virus A(H1N1)pdm09. The percentage of persons with protective antibody titers during the observed period varied for virus A(H3N2) in the range from 58.3 to 75.5%, for influenza B virus — from 59.7 to 82.3%. Accordingly, incidence rate for ILI and ARI in adult groups the population during influenza epidemic caused by these pathogens was lower than in the epidemics, associated with active circulation of influenza A(H1N1)pdm09 virus. The data obtained can be used in influenza forecasting for the upcoming season regarding the etiology and the expected epidemic intensity need for the relevant preventing measures development to decrease the burden from influenza.

Pandemic

Herd Immunity

10.15789/2220-7619-2017-1-27-33

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Citations (11)