Hamida Abdel‐Hamid

Alexandria University

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Influence of free radicals on cardiovascular risk due to occupational exposure to mercury.

PubMed (2001)

Hamida Abdel‐Hamid F C Fahmy Iman A. Sharaf

This study was designed to investigate the relation between occupational exposure to mercury and cardiovascular risk, as well as free radicals. The study subjects included 30 male workers exposed to mercury from a fluorescent lamp plant in Alexandria after exclusion of 12 workers with conditions that may bias the results. A matched control group of 20 male subjects were selected from a food industrial plant. The participants were subjected to interview, clinical examination, electrocardiography and R-R deep breathing variability test as a measure of cardiac autonomic function. Spot urine and venous blood samples were collected to measure mercury levels. Free radicals related markers were measured in serum namely lipid peroxide, superoxide dismutase (SOD) activity, catalase activity and glutathione S-transferase. Results showed significant longer electrocardiographic Q-Tc interval, which is corrected to heart rate, in exposed workers than in controls (p=0.002). The R-R deep breathing variability indices were significantly increased among exposed workers in comparison to controls (maximal variation (MV) ratio, p=0.024 & MV rate, p=0.019). The mercury levels in both urine and blood of exposed workers were significantly higher than controls (p<0.0001), with mean levels exceeding the permissible limits. Free radicals related markers revealed significant higher level of lipid peroxide, as well as significant lower levels of SOD activity, catalase activity and glutathione S-transferase among exposed workers than among controls (p<0.0001 for all). Independent relations were observed between Q-Tc and lipid peroxide, and between MV rate and SOD and catalase activities among exposed workers after adjustment for the confounders by multivariate regression analyses. These findings may suspect a cardiac autonomic dysfunction probably related to free radicals in mercury exposed workers. Also, it may through light on some preventive implications.

Lipid peroxide

Venous blood

Mercury

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Citations (15)

Novel Ag(I)‐based 1,2,4‐Oxadiazole Complexes: Synthesis, X‐Ray Crystal Structure, and Biological Evaluation as Anticancer Candidates

Applied Organometallic Chemistry (2024)

Mohammed Salah Ayoup Rabia E. Alashhab Saied M. Soliman Hamida Abdel‐Hamid David B. Cordes

ABSTRACT The 3,5‐diaryl‐1,2,4‐oxadiazole scaffolds 2 and 3 were synthesized and used as ligands to obtain three novel Ag(I) complexes 4–6 . The structure of the Ag(I) complexes 4–6 has been confirmed by single crystal X‐ray diffraction. Complex 4 has the dinuclear formula [Ag(2)(NO 3 )] 2 . 5 and 6 are monomeric complexes having the formula [Ag(3) 2 (NO 3 )] and [Ag(3) 2 ]ClO 4 , respectively. In vitro, trypsin, ALDH2, and iNOS inhibition activities were assessed for the free ligands and their Ag(I) complexes. Interestingly, Ag(I) complexes 4–6 revealed more prominent trypsin inhibitory activity than the ligands 2 and 3 . The oxadiazole derivative 3 and its Ag(I) complex ( 6 ) showed significant ALDH2 inhibition (45% and 55%, respectively). Complex 6 (IC 50 = 35.61 μM) surpassed its 1,2,4‐oxadiazole ligand 3 (IC 50 = 88 μM) and evidenced the most prominent ALDH2 inhibitory activity. The oxadiazole derivative 3 and its corresponding Ag(I) complexes 5 and 6 showed significant iNOS inhibition (77.77%, 84.12%, and 84.15%, respectively). With IC 50 values of 18.13, 18.15, and 13.96 μM, respectively, complex 6 is the most potent against iNOS, surpassing the reference standard.

Oxadiazole

Derivative (finance)

10.1002/aoc.7804

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Citations (0)

Formulation of promising antibacterial, anticancer, biocompatible and bioactive biomaterial as therapeutic drug delivery system for biologically active compound loaded on clay polymer

Polymer Bulletin (2022)

H. A. Fetouh Hamida Abdel‐Hamid A. A. H. Zaghloul A. E. Ghadban A. M. Ismail

Abstract The synthesized heterocyclic compound: 5-[4-bromobenzylidene amino)-1, 3, 4-thiadiazole-2-thiol abbreviated as BATT possessed good antibacterial activity for various Gram-negative and Gram-positive bacteria. In addition to potent antitumor activity to breast cancer, for the first time, the novelty of this study is facile low-cost formulation of safe antitumor drug delivery system (DDS) for breast cancer from such simple heterocyclic compound. Heterocyclic compound is efficiently and spontaneously incorporated into MMT clay polymer matrix forming novel therapeutic nanocomposite DDS for breast cancer. BATT successfully intercalates MMT clay polymer matrix. Electron donation ability of nanocomposites is confirmed by cyclic voltammetry in terms of small peak-to-peak redox potential $$\Delta E_{{{\text{peak}}}}$$ Δ E peak . Adsorption of BATT on clay is carried out by batch adsorption method. Better adsorption strength at low pH 2 decreased with increasing pH. Adsorption data are analyzed by multiple mathematical models. MMT clay is an efficient carrier polymer heterogonous adsorbent for BATT at optimum conditions: contact time 2.0 h, pH 2 and initial concentration up to 1200 ppm. Adsorption rate constant, k 2 equals 14.6 $$\times$$ × 10 –3 and q e 19 mg g −1 ( R 2 0.999). pH of zero charge of MMT at pH 3 reflected adsorption mechanism of MMT. At pH 2, BATT is loaded on MMT by physi- and chemisorption. At pH 4, BATT is loaded on MMT by chemisorption.

10.1007/s00289-022-04526-2

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Citations (3)

DENTAL STEM CELLS (CONCEPTS AND APPLICATIONS)

Alexandria Dental Journal (2020)

Ahmed Hussein Zeinab Darwish Hanaa Raslan Mahmoud Attia Hamida Abdel‐Hamid

Stem cells constitute the source of differentiated cells for the generation of tissues during development, as well as for regeneration of tissues that are diseased or injured postnatally. The stem cell research has grown exponentially to improve the life of patients with conditions that span from Alzheimer's disease, cardiac ischemia to bone or tooth loss. In dentistry, stem cell biology and tissue engineering are of great interest since they may provide an innovative for generation of clinical material and/or tissue regeneration. Mesenchymal stem cells were demonstrated in dental tissues, including dental pulp, periodontal ligament, dental papilla, and dental follicle. These stem cells can be isolated and grown under defined tissue culture conditions and are potential cells for use in tissue engineering including dental tissue, nerves and bone regeneration under appropriate conditions. This review was performed to study the concepts of stem cells and the most recent application of dental stem cells.

Dental follicle

Dental papilla

Amniotic stem cells

Periodontal fiber

10.21608/adjalexu.2020.88450

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Citations (1)