MohammadHossein MozafaryBazargany

Iran University of Medical Sciences

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Niloofar Gholami

Alborz University of Medical Sciences

Majid Maleki

University of Tabriz

Amir Azimi

Iran University of Medical Sciences

Hadith Rastad

Alborz University of Medical Sciences

Parham Sadeghipour

Iran University of Medical Sciences

Erfan Kohansal

Iran University of Medical Sciences

Samira Kalayinia

Shaheed Rajaei Cardiovascular Medical and Research Center

Ehsan Khalilipur

Shaheed Rajaei Cardiovascular Medical and Research Center

Neda Shafiabadi Hassani

University Hospitals of Cleveland

Alireza Salmanipour

Shaheed Rajaei Cardiovascular Medical and Research Center

Cooperative Institutions

Iran University of Medical Sciences

Shaheed Rajaei Cardiovascular Medical and Research Center

Alborz University of Medical Sciences

Jahrom University of Medical Sciences

Tehran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

University of Tehran

Shiraz University of Medical Sciences

Faculty of 1000 (United States)

Lymphatic Education & Research Network

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Machine learning-based interpretation of non-contrast feature tracking strain analysis and T1/T2 mapping for assessing myocardial viability

Scientific Reports (2025)

Amir GhaffariJolfayi Alireza Salmanipour Kiyan Heshmat‐Ghahdarijani MohammadHossein MozafaryBazargany Amir Azimi

Assessing myocardial viability is crucial for managing ischemic heart disease. While late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is the gold standard for viability evaluation, it has limitations, including contraindications in patients with renal dysfunction and lengthy scan times. This study investigates the potential of non-contrast CMR techniques—feature tracking strain analysis and T1/T2 mapping—combined with machine learning (ML) models, as an alternative to LGE-CMR for myocardial viability assessment. A retrospective analysis was conducted on 79 patients with myocardial infarction (MI) 2–4 weeks post-event. Patients with prior ischemia or poor imaging quality were excluded to ensure robust data acquisition. Various ML algorithms were applied to data from LGE-CMR and non-contrast CMR techniques. Random forest (RF) demonstrated the highest predictive accuracy, with area under the curve (AUC) values of 0.89, 0.90, and 0.92 for left anterior descending (LAD), right coronary artery (RCA), and left circumflex (LCX) coronary artery territories, respectively. For the LAD territory, RF, k-nearest neighbors (KNN), and logistic regression were the top performers, while RCA showed the best results from RF, neural networks (NN), and KNN. In the LCX territory, RF, NN, and logistic regression were most effective. The integration of T1/T2 mapping and strain analysis significantly enhanced myocardial viability prediction, positioning these non-contrast techniques as promising alternatives to LGE-CMR. ML models, particularly RF, provided superior diagnostic accuracy across coronary territories. Future studies should validate these findings across diverse populations and clinical settings.

Feature (linguistics)

Feature tracking

Strain (injury)

10.1038/s41598-024-85029-0

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Comparison of Radial Artery Occlusion Between Traditional Radial Access and Distal Radial Access for Coronary Angiography and Intervention: A Prospective Cohort Study

Heliyon (2024)

Ali Zahedmehr Amir Dousti Mohammad Javad Alemzadeh‐Ansari Abdullah Gharibzadeh Mehdi Sheibani

10.1016/j.heliyon.2024.e39451

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Exploring TTN variants as genetic insights into cardiomyopathy pathogenesis and potential emerging clues to molecular mechanisms in cardiomyopathies

Scientific Reports (2024)

Amir Ghaffari Jolfayi Erfan Kohansal Serwa Ghasemi Niloofar Naderi Mahshid Hesami

Abstract The giant protein titin (TTN) is a sarcomeric protein that forms the myofibrillar backbone for the components of the contractile machinery which plays a crucial role in muscle disorders and cardiomyopathies. Diagnosing TTN pathogenic variants has important implications for patient management and genetic counseling. Genetic testing for TTN variants can help identify individuals at risk for developing cardiomyopathies, allowing for early intervention and personalized treatment strategies. Furthermore, identifying TTN variants can inform prognosis and guide therapeutic decisions. Deciphering the intricate genotype–phenotype correlations between TTN variants and their pathologic traits in cardiomyopathies is imperative for gene-based diagnosis, risk assessment, and personalized clinical management. With the increasing use of next-generation sequencing (NGS), a high number of variants in the TTN gene have been detected in patients with cardiomyopathies. However, not all TTN variants detected in cardiomyopathy cohorts can be assumed to be disease-causing. The interpretation of TTN variants remains challenging due to high background population variation. This narrative review aimed to comprehensively summarize current evidence on TTN variants identified in published cardiomyopathy studies and determine which specific variants are likely pathogenic contributors to cardiomyopathy development.

10.1038/s41598-024-56154-7

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Value of cardiac magnetic resonance feature-tracking in Arrhythmogenic Cardiomyopathy (ACM): A systematic review and meta-analysis

IJC Heart & Vasculature (2024)

MohammadHossein MozafaryBazargany Alireza Salmanipour Amir Ghaffari Jolfayi Amir Azimi Hooman Bakhshandeh

We aimed to assess the diagnostic performance of Cardiac Magnetic Resonance (CMR) strain parameters in ACM patients to evaluate their diagnostic role. We systematically searched MEDLINE, EMBASE, Scopus, and Web of Science. Of the 146 records, 16 were included. All Right Ventricle (RV) global strains were significantly reduced in ACM patients compared to controls (Standardized Mean Difference (SMD)[95 % Confidence Interval (CI)]: Longitudinal 1.31[0.79,1.83]; Circumferential 0.88[0.34,1.42]; Radial -1.14[-1.78,-0.51]). Similarly, all Left Ventricle (LV) global strains were significantly impaired in ACM compared to healthy controls (SDM [95 %CI]: Longitudinal 0.88[0.48,12.28], Circumferential 0.97[0.72,1.22], Radial -1.24[-1.49,-1.00]). Regarding regional RV strains, longitudinal and circumferential strains were significantly reduced in basal and mid-wall regions, while they were comparable to controls in the apical regions. The RV radial strain was reduced only within the basal region in the ACM group compared to controls. ACM patients exhibited significant impairment of regional LV strains in all regions-basal, mid-wall, and apical-compared to control subjects. Ultimately, despite the limitations of CMR-FT in terms of reproducibility, it is superior to qualitative assessment in detecting wall motion abnormalities. Thus, integrating CMR-FT with ACM diagnostic criteria seems to enhance its diagnostic yield.

Feature tracking

Cardiac magnetic resonance

Feature (linguistics)

Value (mathematics)

Tracking (education)

10.1016/j.ijcha.2024.101455

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Predictive value of inflammatory indices for one year outcome of primary percutaneous coronary intervention on saphenous vein graft in post-coronary artery bypass grafting patients

Acta Cardiologica (2025)

MohammadHossein MozafaryBazargany Niloofar Gholami Amir Azimi Mohsen Maadani Sara Adimi

Background This study aims to evaluate the prognostic value of the inflammatory indices i.e. Platelet Lymphocyte Ratio (PLR), Neutrophil Lymphocyte Ratio (NLR), and Systemic Immune Inflammation Index (SII) as potential predictors of Major Adverse Cardiovascular Event (MACE) in patients undergoing Primary Percutaneous Coronary Intervention (PPCI) on Saphenous Vein Graft (SVG) with a history of Coronary Artery Bypass Graft (CABG).

Mace

Saphenous vein graft

10.1080/00015385.2024.2413221

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Cardiac Magnetic Resonance Imaging Findings in 2954 COVID‐19 Adult Survivors: A Comprehensive Systematic Review

Journal of Magnetic Resonance Imaging (2021)

Neda Shafiabadi Hassani Hamed Talakoob Hosein Karim MohammadHossein MozafaryBazargany Hadith Rastad

Background Recent studies have utilized MRI to determine the extent to which COVID‐19 survivors may experience cardiac sequels after recovery. Purpose To systematically review the main cardiac MRI findings in COVID‐19 adult survivors. Study type Systematic review. Subjects A total of 2954 COVID‐19 adult survivors from 16 studies. Field Strength/sequence Late gadolinium enhancement (LGE), parametric mapping (T1‐native, T2, T1‐post (extracellular volume fraction [ECV]), T2‐weighted sequences (myocardium/pericardium), at 1.5 T and 3 T. Assessment A systematic search was performed on PubMed, Embase, and Google scholar databases using Boolean operators and the relevant key terms covering COVID‐19, cardiac injury, CMR, and follow‐up. MRI data, including (if available) T1, T2, extra cellular volume, presence of myocardial or pericardial late gadolinium enhancement (LGE) and left and right ventricular ejection fraction were extracted. Statistical Tests The main results of the included studies are summarized. No additional statistical analysis was performed. Results Of 1601 articles retrieved from the initial search, 12 cohorts and 10 case series met our eligibility criteria. The rate of raised T1 in COVID‐19 adult survivors varied across studies from 0% to 73%. Raised T2 was detected in none of patients in 4 out of 15 studies, and in the remaining studies, its rate ranged from 2% to 60%. In most studies, LGE (myocardial or pericardial) was observed in COVID‐19 survivors, the rate ranging from 4% to 100%. Myocardial LGE mainly had nonischemic patterns. None of the cohort studies observed myocardial LGE in “healthy” controls. Most studies found that patients who recovered from COVID‐19 had a significantly greater T1 and T2 compared to participants in the corresponding control group. Data Conclusion Findings of MRI studies suggest the presence of myocardial and pericardial involvement in a notable number of patients recovered from COVID‐19. Level of Evidence 3 Technical Efficacy Stage 3

Cardiac magnetic resonance

10.1002/jmri.27852

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Citations (32)

Immature Platelet Fraction and Acute Coronary Syndrome; a Systematic Review and Meta-Analysis.

PubMed (2024)

Elmira Jafari Afshar Vahid Shahnavaz Hamed Talakoob Parnaz Kafialqora Aryan Madady

Immature Platelet Fraction (IPF) is a measure of the proportion of reticulated platelets (RPs) to all platelets in circulation. IPF may have both prognostic and diagnostic values in patients with Acute Coronary Syndrome (ACS). This study aims to comprehensively summarize the diagnostic utility of IPF levels in patients with ACS, specifically focusing on its ability to differentiate between different subtypes of ACS.

10.22037/aaem.v12i1.2292

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Diagnostic Indicators of ECG for Coronary Slow Flow Phenomenon; a Systematic Review and Meta-Analysis.

PubMed (2024)

MohammadHossein MozafaryBazargany Parham Samimisedeh Niloofar Gholami Elmira Jafari Afshar Amirhossein Memari

Currently, epicardial coronary angiography is still the only diagnostic tool for Coronary Slow Flow Phenomenon (CSFP). This study aimed to systematically review studies that compared Electrocardiogram (ECG) findings between patients with and without CSFP.

Phenomenon

10.22037/aaem.v12i1.2202

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Assessing the impact of omega-3 fatty acids on ventricular tachyarrhythmia and survival in patients with ICDs: A systematic review and meta-analysis

IJC Heart & Vasculature (2024)

Erfan Kohansal Amir Askarinejad MohammadHossein MozafaryBazargany Amirreza Sabahizadeh SeyedAbbas Pakmehr

Recent studies investigating the effects of fish oil on shocks administered by ICDs in patients with ventricular tachycardias produced inconclusive results. This systematic review aims to evaluate the effectiveness of omega-3 polyunsaturated fatty acids in lowering the risk of life-threatening VTs among individuals with implantable cardioverter-defibrillators. We searched five databases, including Central, PubMed, EMBASE, Web of Science, and Scopus, for studies evaluating the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) for the prevention of ICD events for VT or VF, published up to December 1, 2023. Four trials were finally included in the study. The pooled risk ratios for mortality and ICD events were 0.87 (95% CI:0.58–1.32) and 0.75 (95% CI:0.48–1.18), respectively. No significant effect was discovered to support the antiarrhythmic properties or survival advantages of n-3 polyunsaturated fatty acids (PUFA) in individuals with implanted implantable cardioverter-defibrillators (ICD).

Web of science

10.1016/j.ijcha.2024.101397

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Citations (4)

A novel likely pathogenic homozygous RBCK1 variant in dilated cardiomyopathy with muscle weakness

ESC Heart Failure (2024)

MohammadHossein MozafaryBazargany Shiva Esmaeili Mahshid Hesami Golnaz Houshmand Mohamad Mahdavi

Polyglucosan body myopathy 1 (PGBM1) is a type of glycogen storage disease where polyglucosan accumulation leads to cardiomyopathy and skeletal muscle myopathy. Variants of RBCK1 is related with PGBM1. We present a newly discovered pathogenic RBCK1 variant resulting in dilated cardiomyopathy (DCM) and a comprehensive literature review.

Dilated Cardiomyopathy

Muscle disease

Muscle weakness

10.1002/ehf2.14702

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Citations (3)