Ze-Hao Wang

University of Science and Technology of China

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Guang‐Can Guo

University of Science and Technology of China

Shuang Wang

University of Science and Technology of China

Wei Chen

University of Science and Technology of China

Zheng‐Fu Han

University of Science and Technology of China

De‐Yong He

University of Science and Technology of China

Feng-Yu Lu

University of Science and Technology of China

Zhen−Qiang Yin

University of Science and Technology of China

Guan‐Jie Fan‐Yuan

University of Science and Technology of China

Zhen‐Qiang Yin

University of Science and Technology of China

Xiang-Dong Chen

University of Science and Technology of China

Cooperative Institutions

University of Science and Technology of China

Fudan University Shanghai Cancer Center

Chinese Academy of Sciences

Shanghai Medical College of Fudan University

Fudan University

State Key Laboratory of Cryptology

CAS Key Laboratory of Urban Pollutant Conversion

Shanghai Jiao Tong University

Shanghai Cancer Institute

Yunnan Agricultural University

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Tight finite-key analysis for quantum key distribution without monitoring signal disturbance

npj Quantum Information (2021)

Hang Liu Zhen‐Qiang Yin Rong Wang Ze-Hao Wang Shuang Wang

Abstract Unlike traditional communication, quantum key distribution (QKD) can reach unconditional security and thus attracts intensive studies. Among all existing QKD protocols, round-robin-differential-phase-shift (RRDPS) protocol can be running without monitoring signal disturbance, which significantly simplifies its flow and improves its tolerance of error rate. Although several security proofs of RRDPS have been given, a tight finite-key analysis with a practical phase-randomized source is still missing. In this paper, we propose an improved security proof of RRDPS against the most general coherent attack based on the entropic uncertainty relation. What’s more, with the help of Azuma’s inequality, our proof can tackle finite-key effects primely. The proposed finite-key analysis keeps the advantages of phase randomization source and indicates experimentally acceptable numbers of pulses are sufficient to approach the asymptotical bound closely. The results shed light on practical QKD without monitoring signal disturbance.

Quantum key distribution

SIGNAL (programming language)

10.1038/s41534-021-00428-9

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Citations (2)

Neoadjuvant Anthracycline Followed by Toripalimab Combined with Nab-Paclitaxel in Patients with Early Triple-Negative Breast Cancer (NeoTENNIS): A Single-Arm, Phase II Study

Min He Shuang Hao Linxiaoxi Ma Bingqiu Xiu Benlong Yang

Download This Paper Open PDF in Browser Add Paper to My Library Share: Permalink Using these links will ensure access to this page indefinitely Copy URL Copy DOI

Nab-paclitaxel

Triple-negative breast cancer

10.2139/ssrn.4681848

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Intensity Tomography Method for Secure and High-Performance Quantum Key Distribution

Journal of Lightwave Technology (2023)

Feng-Yu Lu Ze-Hao Wang Shuang Wang Zhen−Qiang Yin Jia-Lin Chen

Decoy-state method has greatly filled in loopholes from multi-photon pulses in the field of quantum key distribution (QKD) and it has been employed in almost all practical QKD systems in recent years. However, security and performance of the practical decoy-state QKDs are still limited by inaccurate modulations such as random intensity fluctuation and correlated intensity fluctuation. In this work, an intensity tomography method is proposed as a countermeasure against these fluctuations. It has an ability to tightly bound the unknown density matrices of photon-number state and accurately calibrate the fluctuations by measuring the decoy states with a local single-photon detector. We verified the tomography method by experiments and simulations. The results indicated that our method can efficiently mitigate the flaws from these fluctuations to improve the protocol performance and practical security. Noting that these fluctuations are inevitable in practical QKDs, our method would pave the avenue for QKD's practical applications.

Quantum key distribution

Intensity

Decoy

Countermeasure

10.1109/jlt.2023.3247766

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Citations (2)

Qubit-Based Synchronization Algorithm for Measurement-Device-Independent Quantum Key Distribution

Journal of Lightwave Technology (2024)

Zhengkai Huang Jia-Xuan Li Feng-Yu Lu Ze-Hao Wang Shuang Wang

Quantum key distribution

10.1109/jlt.2024.3520212

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Quality assessment of clinical guidelines in China: 1993 - 2010.

PubMed (2012)

Yaolong Chen Liang Yao Xiaojuan Xiao Qi Wang Ze-Hao Wang

Clinical practice guidelines (CPGs) play an important role in healthcare in China as well as in the world. However, the current status and trends of Chinese CPGs are unknown. The aim of this study was to systematically review the present situation and the quality of Chinese CPGs published in the peer-reviewed medical literature.To identify Chinese CPGs, a systematic search of relevant literature databases (CBM, WANFANG, VIP, and CNKI) was performed for the period January 1978 to December 2010. We used the AGREE II instrument to assess the quality of the included guidelines.We evaluated 269 guidelines published in 115 medical journals from 1993 to 2010 and produced by 256 different developers. Only four guidelines (1%) described the systematic methods for searching and selecting the evidence, 14 (5%) guidelines indicated an explicit link between the supporting evidence and the recommendations, only one guideline used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Thirty-one guidelines (12%) mentioned updates and the average frequency of update was 5.5 years; none described a procedure for updating the guideline. From the assessment with the Appraisal of Guidelines for Research and Ecaluation II (AGREE II), the mean scores were low for the domains "scope and purpose" (19%) and "clarity of presentation" (26%) and very low for the other domains ("rigour of development" 7%, "stakeholder involvement" 8%, "applicability" 6% and "editorial independence" 2%).Compared with other studies on the quality of guidelines assessed with the AGREE instrument in other countries, Chinese CPGs received lower scores, which indicates a relatively poor quality of the guidelines. However, there was some increase over time.

Rigour

Guideline

CLARITY

Scope (computer science)

Grading (engineering)

Evidence-Based Medicine

Source

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Citations (42)

High-resolution multiphoton microscopy with a low-power continuous wave laser pump

Optics Letters (2018)

Xiang-Dong Chen Li Shen Bo Du Dong Yang Ze-Hao Wang

Multiphoton microscopy (MPM) has been widely used for three-dimensional biological imaging. Here, based on the photon-induced charge state conversion process, we demonstrated a low-power high-resolution MPM with a nitrogen vacancy (NV) center in diamond. Continuous wave green and orange lasers were used to pump and detect the two-photon charge state conversion, respectively. The power of the laser for multiphoton excitation was 40 μW. Both the axial and lateral resolutions were improved approximately 1.5 times compared with confocal microscopy. The results can be used to improve the resolution of the NV center-based quantum sensing and biological imaging.

Continuous wave

Two-photon excitation microscopy

Biological Imaging

10.1364/ol.43.000699

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Citations (7)

Unbalanced-basis-misalignment-tolerant measurement-device-independent quantum key distribution

Optica (2022)

Feng-Yu Lu Ze-Hao Wang Zhen−Qiang Yin Shuang Wang Rong Wang

Measurement-device-independent quantum key distribution (MDIQKD) is a revolutionary protocol since it is physically immune to all attacks on the detection side. However, the protocol still keeps the strict assumptions on the source side that the four BB84-states must be perfectly prepared to ensure security. Some protocols release part of the assumptions in the encoding system to keep the practical security, but the performance would be dramatically reduced. In this work, we present a MDIQKD protocol that requires less knowledge of encoding system to combat the troublesome modulation errors and fluctuations. We have also experimentally demonstrated the protocol. The result indicates the high-performance and good security for its practical applications. Besides, its robustness and flexibility exhibit a good value for complex scenarios such as the QKD networks.

Quantum key distribution

BB84

Robustness

Measurement device

10.1364/optica.454228

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Citations (21)

Synthesis, cytotoxicity, and molecular docking of methylated (–)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives as novel antitumor agents

Journal of Chemical Research (2021)

Cheng‐Ting Zi Ze-Hao Wang Jing Shi Bo-Ya Shi Ning Zhang

A series of novel methylated (–)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives is synthesized by utilizing the click reaction. Evaluation of their cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) using the MTT assay shows that most of these compounds exhibit weak cytotoxicity. It is observed that compound 12 shows the highest activity against A-549 cells with an IC 50 value of 10.27 ± 0.90 μM. Molecular docking results suggested that this compound 12 has a higher binding affinity for epidermal growth factor receptor than for tubulin. Our findings support the utility of compound 12 as a novel compound for the further development of anticancer agents.

Docking (animal)

MTT assay

Gallate

10.1177/17475198211027328

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Citations (1)

Transmittance-invariant phase modulator for chip-based quantum key distribution

Optics Express (2022)

Peng Ye Wei Chen Ze-Hao Wang Guowei Zhang Yu-Yang Ding

In chip-based quantum key distribution (QKD) systems, the non-ideal quantum state preparation due to the imperfect electro-optic phase modulators (EOPM) decreases the secret key rate and introduces potential vulnerabilities. We propose and implement an on-chip transmittance-invariant phase modulator (TIPM) to solve this problem. Simulated and experimental results show that TIPM can eliminate the correlation between phase, intensity, and polarization of quantum states caused by phase-dependent loss. The design can tolerate a significant fabrication mismatch and is universal to multi-material platforms. Furthermore, TIPM increases the modulation depth achievable by EOPMs in standard process design kit (PDK). The proposal of TIPM can improve the practical security and performance of the chip-based QKD systems.

Quantum key distribution

10.1364/oe.470025

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Citations (7)

Experimental demonstration of fully passive quantum key distribution

arXiv (Cornell University) (2023)

Feng-Yu Lu Ze-Hao Wang Jialin Chen Shuang Wang Zhen‐Qiang Yin

The passive approach to quantum key distribution (QKD) consists of removing all active modulation from the users' devices, a highly desirable countermeasure to get rid of modulator side-channels. Nevertheless, active modulation has not been completely removed in QKD systems so far, due to both theoretical and practical limitations. In this work, we present a fully passive time-bin encoding QKD system and report on the successful implementation of a modulator-free QKD link. According to the latest theoretical analysis, our prototype is capable of delivering competitive secret key rates in the finite key regime.

Quantum key distribution

Modulation (music)

Countermeasure

10.48550/arxiv.2304.11655

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Citations (1)