Ali H. Hajeer

King Saud bin Abdulaziz University for Health Sciences

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William Ollier

Manchester Metropolitan University

Dunia Jawdat

King Saud bin Abdulaziz University for Health Sciences

MÁ

Miguel Á. González‐Gay

Universidad de Cantabria

Jane Worthington

University of Manchester

Carlos Garcı́a-Porrúa

Hospital Universitario Lucus Augusti

Wendy Thomson

Versus Arthritis

Hana Fakhoury

Alfaisal University

Wer Ollier

Manchester Academic Health Science Centre

Ahmed Alaskar

King Abdulaziz Medical City

Yaseen M. Arabi

National Guard Health Affairs

Cooperative Institutions

King Saud bin Abdulaziz University for Health Sciences

209

King Abdulaziz Medical City

203

National Guard Health Affairs

181

King Abdullah International Medical Research Center

156

University of Manchester

105

MRC Epidemiology Unit

Manchester Academic Health Science Centre

King Saud University

University College London

King Faisal Specialist Hospital & Research Centre

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The sensitivity of different analytical methods to detect disease susceptibility genes in rheumatoid arthritis sibling pair families.

PubMed (1997)

Angela J. Marlow Sally John Ali H. Hajeer William Ollier Alan J. Silman

Our aim was to compare the sensitivity of 4 analytical methods to detect linkage to a known disease susceptibility locus, HLA-DRB1, in 100 rheumatoid arthritis sibling pair families with incomplete parental genotype information. Genotypes for the HLA-DRB1 and HLA-A loci were analyzed using (1) identity-by-descent (IBD), considering inheritance of maternal and paternal alleles separately; (2) maximum likelihood score-IBD (MLS-IBD), which infers missing parental genotypes; (3) identity-by-state (IBS), which does not require parental genotypes; and (4) transmission disequilibrium test (TDT), which uses affected offspring with a heterozygous parent. Due to the small number of informative meoisis for HLA-DRB1, the IBD analysis was not significant for linkage (p = 0.014). HLA-A was more informative (p = 0.0002). The MLS-IBD method for HLA-DRB1 (p = 0.00004) and HLA-A (p < or = 0.00001) was significant. Using IBS both loci gave highly significant evidence of linkage, (p < < 0.00001). The TDT detected HLA-DRB1*0401 as the allele associated with RA; no HLA-A allele was associated. Thus, sib pair families with limited parental genotypes can be used to detect disease susceptibility loci, but when selecting the method of analysis the informativeness of the markers should be taken into account.

Identity by descent

Transmission disequilibrium test

Linkage Disequilibrium

Genetic linkage

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Citations (5)

Neutrophils and Lymphoid Chimerism After Adult Living-Related Liver Transplantation From a Homozygous Donor

Transplantation Proceedings (2005)

Ali H. Hajeer S. Issa A. Alaskar K. Abdullah Mohammad Hosny Awad

10.1016/j.transproceed.2005.11.006

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Citations (3)

TNF-? gene polymorphism: Clinical and biological implications

Microscopy Research and Technique (2000)

Ali H. Hajeer Ian V. Hutchinson

TNF-α is a proinflammatory cytokine that has been implicated in the severity of different immune-regulated diseases including autoimmune diseases and transplantation. The gene for TNF-α is located within the MHC region on chromosome 6p21.3. This is a highly polymorphic region, and the TNF-α itself contains a large number of polymorphisms. Some of these polymorphisms form extended haplotypes with the HLA class I and II alleles. TNF polymorphisms have been investigated in different diseases and most often whenever there is an HLA association with the disease (for example IDDM and RA) association(s) with TNF polymorphisms has been described. There are many studies on the function of the TNF polymorphisms showing the influence of the different alleles on the in vitro and in vivo levels of TNF production. However, recent studies in animal models suggest that not only polymorphisms within the TNF cluster are important in the regulation of TNF production but also the receptors as well (TNF R). This suggests that investigating polymorphisms within the TNF cluster and TNF receptors will be important in understanding the role of TNF regulation in a given disease. Microsc. Res. Tech. 50:216–228, 2000. © 2000 Wiley-Liss, Inc.

Proinflammatory cytokine

10.1002/1097-0029(20000801)50:3<216::aid-jemt5>3.0.co;2-q

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Citations (266)

In vitroproduction of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene

European Journal of Immunogenetics (1999)

Vera Pravica Argiris Asderakis Chris Perrey Ali H. Hajeer P. J. Sinnott

The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-gamma (IFN-gamma) production. In vitro production of IFN-gamma showed a significant correlation with the presence of allele #2.

10.1046/j.1365-2370.1999.00122.x

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Citations (466)

Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0

HLA (2020)

Carolyn Katovich Hurley Jane Kempenich Kim Wadsworth Jürgen Sauter Jan A. Hofmann

A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two‐field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well‐documented (≥5 occurrences) or not‐CIWD. Overall 26% of alleles in IPD‐IMGT/HLA version 3.31.0 at P group resolution fall into the three CIWD categories. The two‐field catalog includes 18% (n = 545) common, 17% (n = 513) intermediate, and 65% (n = 1997) well‐documented alleles. Full‐field allele frequency data are provided but are limited in value by the variations in resolution used by the registries. A recommended CIWD list is based on the most frequent category in the total or any of the seven geographic/ancestral/ethnic groups. Data are also provided so users can compile a catalog specific to the population groups that they serve. Comparisons are made to three previous CWD reports representing more limited population groups. This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole.

10.1111/tan.13811

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Citations (119)

Comparison Of Different Case Definitions For Adrenal Insufficiency In Cirrhotic Patients With Septic Shock

Yaseen M. Arabi Abdulrahman Aljumah Ousama Dabbagh Hani Tamim Asgar Rishu

10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6131

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Citations (0)

Hormone therapy for endometriosis and surgical menopause

Cochrane database of systematic reviews (2006)

Hanan Al Kadri H AL Fozan Ali H. Hajeer Samar Hassan

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: This review aims to look at pain recurrence for women with endometriosis who used hormone therapy post surgical menopause.

Surgical Menopause

Hormone Therapy

10.1002/14651858.cd005997

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Citations (4)

Authors Reply

Saudi Journal of Kidney Diseases and Transplantation (2013)

Ali H. Hajeer

10.4103/1319-2442.118072

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Citations (0)

Hyperglycemia in Critically Ill Cirrhotic Patients.

Hasan M. Al‐Dorzi Hani Tamim Waleed Tamimi Ali H. Hajeer Yaseen M. Arabi

10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5832

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Einfluss von Genvariationen im Major Histokompatibilitäts-Komplex auf das Entstehungsrisiko von Plattenepithelkarzinomen im Kopf-Hals-Bereich

Laryngo-Rhino-Otologie (2001)

C. Matthias V. Jähnke Ali H. Hajeer W E Ollier Anthony A. Fryer

While cigarette smoking and alcohol consumption are risk factors for squamous cell carcinomas (SCC) of the head and neck, genetic factors are also significant. The gene of tumor necrosis factor (TNF) is located in the major histocompatibility complex class III and the cytokine has pleiotropic actions some of which are anticarcinogenic. As this gene complex is polymorphic with microsatellite markers identified it is a further candidate for head and neck cancer susceptibility.We used a case-control approach to study the influence of polymorphism at the A-D markers on susceptibility in 113 controls, 265 laryngeal and 123 oral cavity/pharyngeal SCC cases. Genotypes were identified on polyacrylamide gels in an automated DNA sequencer after amplification with fluorescently-labeled primers.We found no differences in allele frequencies between controls and oral cavity/pharyngeal SCC cases but the frequency of B3 was greater in the laryngeal SCC cases than controls (p = 0.004, odds ratio 2.8). Homozygosity for B3 conferred an increased risk of laryngeal cancer compared with controls (p = 0.021, odds ratio 10.8).The data provide the first evidence that allelism at MHC class III microsatellite markers is associated with risk to laryngeal SCC.

Genetic predisposition

10.1055/s-2001-17837

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Citations (1)