Diana Becker

Johannes Gutenberg University Mainz

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Jens U. Marquardt

University Medical Center

Peter R. Galle

University Medical Center of the Johannes Gutenberg University Mainz

Darko Castven

University Medical Center

Carolin Czauderna

University of Lübeck

Beate K. Straub

Johannes Gutenberg University Mainz

Arndt Weinmann

University Medical Center of the Johannes Gutenberg University Mainz

Hauke Lang

Johannes Gutenberg University Mainz

Stefanie Heilmann‐Heimbach

University of Bonn

Peter Grimminger

University Hospital Carl Gustav Carus

J Hajduk

University Hospital Schleswig-Holstein

Cooperative Institutions

Johannes Gutenberg University Mainz

University Medical Center of the Johannes Gutenberg University Mainz

Heidelberg University

National Institutes of Health

University Hospital Heidelberg

University of Lübeck

University Medical Center

Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie

University Hospital Schleswig-Holstein

Medizinische Hochschule Hannover

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Die Genexpressionsprofile von Lebergewebe, subkutanem und viszeralem Fettgewebe korrelieren mit der Krankheitsschwere der metabolischen Fettlebererkrankung bei stark adipösen Patienten

Diabetologie und Stoffwechsel (2024)

Lina Jegodzinski Darko Castven Diana Becker Juliana Marques Affonso Alvaro Mallagaray de Benito

Einführung: Die metabolisch-assoziierte steatotische Lebererkrankung (MASLD) ist durch ein heterogenes klinisches Bild gekennzeichnet. Das Vorhandensein von Stoffwechselstörungen, insbesondere Adipositas, spielt eine wichtige pathophysiologische Rolle. Die Lokalisation der Fettansammlungen in den verschiedenen Fettgeweben ist durch unterschiedliche phänotypische und molekulare Eigenschaften charakterisiert. Diese stehen in engem Zusammenhang mit dem Schweregrad der MASLD. Die zugrundeliegenden Mechanismen und Eigenschaften von viszeralem und subkutanem Fettgewebe sind größtenteils noch unbekannt.

10.1055/s-0044-1785242

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Tables S1 - 5 from Mitochondrial BAX Determines the Predisposition to Apoptosis in Human AML

Frank Reichenbach Cornelius Wiedenmann Enrico Schalk Diana Becker Kathrin Funk

<p>S1 BAX/BAK localization for the test cohort S2 clinical characterization of patient cohorts S3 GISTIC analysis of the test cohort S4 BAX/BAK localization for the validation cohort S5 Multivariate analysis of variance for human AML survival probablity</p>

10.1158/1078-0432.22462898.v1

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Control of mitogenic and motogenic pathways by miR-198, diminishing hepatoma cell growth and migration

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2013)

N Elfimova Elisabeth Sievers H Eischeid M Kwiecinski A Noetel

10.17615/vd8v-1450

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Genexpressionsprofile von Leber-, subkutanem und viszeralem Fettgewebe rekapitulieren die schrittweise Progression von MASLD zu MASH

Zeitschrift für Gastroenterologie (2024)

Lina Jegodzinski Darko Castven Diana Becker Juliana Marques Affonso Álvaro Mallagaray

10.1055/s-0044-1789819

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Application of patient derived liver cancer cell lines for phenotypic characterization and therapeutic target identification

Zeitschrift für Gastroenterologie (2018)

Darko Castven Diana Becker Carolin Czauderna D Wilhelm Jesper B. Andersen

Primary liver cancers (PLCs) rank among the most lethal solid cancers worldwide due to lack of effective biomarkers for early detection and limited treatment options in advanced stages. While cell lines have been of significant impact for cancer research over the last decades, development of in vitro models that closely recapitulate phenotypic and molecular diversity of the primary cancers is urgently needed to improve the outcome of patients.

Liver Cancer

Identification

Cancer cell lines

10.1055/s-0038-1668934

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The relevance of mitochondrial BAX re-distribution for apoptotic evasion in human hepatocellular carcinoma

Zeitschrift für Gastroenterologie (2020)

J Hajduk Kathrin Funk Carolin Czauderna Diana Becker Frank Reichenbach

Resistance to cell death is a hallmark of many cancers including hepatocellular carcinoma (HCC). The chronic inflammatory microenvironment within liver predisposes HCC development and progression. Herein, tumor predisposition to apoptosis is reflected by the dynamic distribution of the pro-apoptotic BCL-2 proteins BAX/BAK between cytosol and mitochondria. However, underlying molecular mechanisms that maintain this equilibrium during hepatocarcinogenesis remain elusive.

10.1055/s-0039-3402236

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Next generation sequencing of the Ago2 interacting transcriptome identified chemokine family members as novel targets of neuronal microRNAs in hepatic stellate cells

Zeitschrift für Gastroenterologie (2013)

A Noetel N Elfimova Diana Becker Peter Nürnberg Ashley I. Teufel

Background: After myofibroblastic transdifferentiation hepatic stellate cells (HSC), mainly involved in liver fibrosis by extracellular matrix production, exhibit an altered growth factor profile including increased expression of neuronal mediators. Here, we analyzed putative targets of neuronal microRNAs miR-9, miR-125b, and miR-128 by deep sequencing of the transcript population, interacting with miRNA/Argonaute 2 (Ago2) complex in myofibroblastic HSC.

Hepatic stellate cell

Argonaute

Transdifferentiation

10.1055/s-0032-1331937

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THU-254-YI Differential gene expression profiles of liver tissue, subcutaneous and visceral adipose tissue delineates severity of MASLD in heavily obese patients

Journal of Hepatology (2024)

Lina Jegodzinski Darko Castven Diana Becker Juliana Marques Affonso Alvaro Mallagaray de Benito

Subcutaneous adipose tissue

Liver tissue

Subcutaneous fat

10.1016/s0168-8278(24)01714-8

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Application of Patient-Derived Liver Cancer Cells in Personalized Treatment Approach: Phenotypic Characterization and Therapeutic Target Identification

Zeitschrift für Gastroenterologie (2018)

Darko Castven Diana Becker Carolin Czauderna D Wilhelm Jesper B. Andersen

Identification

Liver Cancer

Personalized Medicine

10.1055/s-0037-1612765

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Activation of tumor initiating cells during anti-angiogenic therapies promotes tumor progression and relapse formation in hepatocellular carcinoma

Zeitschrift für Gastroenterologie (2016)

Darko Castven Carolin Czauderna Diana Becker MA Wörns SS Thorgeirsson

Introduction: Neo-angiogenesis is frequently observed during progression of hepatocellular carcinoma (HCC) and often associated with poor clinical outcome. However, development of chemoresistance and relapse formation is observed in the majority of patients. Compelling evidence suggest that tumor-initiating cells (TICs) may contribute to the acquisition of resistant properties, but their exact role in this process for HCC remains to be defined. Here, we evaluate the importance of TICs in the development of resistance and formation of relapse in HCC during anti-angiogenic therapies and define the concomitant adaptive molecular changes.

Tumor progression

Concomitant

10.1055/s-0036-1597456

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