Miho M. Shida

Institute of Theoretical and Experimental Biophysics

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Daniel I. H. Linzer

Research Corporation for Science Advancement

Vera A. Rakhmanova

Hurley Medical Center

Kimimichi Obata

Biospherical Instruments (United States)

Michael J. Soares

University of Kansas Medical Center

Susan R. Ross

University of Illinois Chicago

Kazunori Hirayoshi

Kyoto University

Ruozi Qiu

Duke University

Ramoun D. Jones

Mayo General Hospital

Gary W. Ashley

ProLynx (United States)

Thomas J. McIntosh

Duke University

Cooperative Institutions

Northwestern University

Duke University

Institute of Theoretical and Experimental Biophysics

National Institutes of Health

University of Minnesota

Precision Research (United States)

Sumitomo Precision Products (Japan)

University of Kansas Medical Center

University of Kansas

Kyushu University

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Transcriptional regulation of the vimentin-encoding gene in mouse myeloid leukemia M1 cells

Gene (1995)

Nobuhiro Nakamura Miho M. Shida Kazunori Hirayoshi Kazuhiro Nagata

Transcription

TATA box

CAAT box

Response element

10.1016/0378-1119(95)00600-1

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Citations (8)

Three‐dimensional microarray platform applied to single nucleotide polymorphism analysis

Biotechnology and Bioengineering (2004)

Donald I. Stimpson Sheila M. Knepper Miho M. Shida Kimimichi Obata Hideji Tajima

Abstract Bio‐Strand, Inc., has developed a novel DNA microarray platform utilizing a three‐dimensional (3D) DNA format. DNA probes or polymerase chain reaction (PCR) products are spotted onto a thread‐like scaffold, which is then wound onto a cylindrical core. By wrapping the thread around the core, high efficiencies are achieved in sample analysis. Using allele‐specific oligo (ASO) competitive hybridization (with Cy5 fluorescently labeled sequences), hybridized arrays are visualized using a helium–neon (HeNe) laser and quantitated/scored. The method can readily detect single nucleotide differences. We demonstrate the use of this Bio‐Strand 3D array in the analysis of a single nucleotide polymorphism (SNP). © 2004 Wiley Periodicals, Inc.

SNP array

10.1002/bit.20087

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Citations (13)

Transcriptional Regulation of the Placental Lactogen Genes in Mouse Trophoblast Giant Cells

Springer eBooks (1993)

Miho M. Shida Yuk-Kiu Ng Daniel I. H. Linzer

Placental lactogen

Trophoblast

Human placental lactogen

10.1007/978-1-4612-2718-2_16

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Citations (5)

Trophoblast-specific transcription from the mouse placental lactogen-I gene promoter.

Molecular Endocrinology (1993)

Miho M. Shida Y.K. Ng Michael J. Soares Daniel I. H. Linzer

We have isolated the gene encoding mouse placental lactogen-I and characterized the promoter region of this gene by transient and stable transfection. Promoter sequences extending 274 basepairs (bp) up-stream from the start site of transcription contain all of the elements necessary for maximal expression upon transient transfection into the rat choriocarcinoma Rcho-1 cell line; these Rcho-1 cultures contain both proliferative trophoblast stem cells and terminally differentiated trophoblast giant cells. In stably transfected cell lines, expression from this promoter increases as the percentage of differentiated cells in the culture increases. In contrast to these results in trophoblast cells, the 274-bp promoter as well as a promoter region extending 2700 bp up-stream of the transcriptional start site are unable to drive transcription in a variety of other cell types. Mutational and protein binding analyses indicate that two AP-1 sites are required for maximal expression in Rcho-1 cells, and that the composition of the AP-1 transcription factor may vary as differentiation in the cell culture increases. In addition to these two AP-1 sites, at least one other element appears to be critical for promoter activity in trophoblast cells.

Trophoblast

Placental lactogen

Transcription

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10.1210/mend.7.2.8469232

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Citations (68)

Physical and Biological Properties of Cationic Triesters of Phosphatidylcholine

Biophysical Journal (1999)

Robert C. MacDonald Gary W. Ashley Miho M. Shida Vera A. Rakhmanova Yury S. Tarahovsky

Cationic polymerization

Aqueous two-phase system

10.1016/s0006-3495(99)77095-5

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Citations (132)

Placental-specific expression from the mouse placental lactogen II gene promoter.

Proceedings of the National Academy of Sciences (1992)

Miho M. Shida Laurie Jackson‐Grusby Susan R. Ross Daniel I. H. Linzer

The gene for mouse placental lactogen II (mPL-II) has been isolated and characterized. This gene contains five exons, with a transcription start site 59 nucleotides upstream of the translation initiation ATG. Introduction of a DNA construct containing 2.7 kilobases of sequence upstream of the mPL-II transcription initiation site directed the synthesis of a linked coding region for the simian virus 40 large and small tumor antigens in placental trophoblast giant cells of transgenic mice. The pattern of simian virus 40 transgene expression in the placenta was indistinguishable from that of the endogenous mPL-II gene. In contrast, the first 569 base pairs upstream of the transcription start site proved insufficient to direct placental expression. Thus, one or more elements required for placental trophoblast giant cell expression have been localized to a region between -2700 and -569 of the mPL-II gene.

Placental lactogen

Human placental lactogen

Trophoblast

Transcription

10.1073/pnas.89.9.3864

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Citations (53)