Jia‐Fu Pan

National Taiwan University

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Kwunmin Chen

National Taiwan Normal University

Chun‐Hung Lin

National Taiwan University

Kung‐Shuo Yang

National Taiwan Normal University

U. Venkatesham

Linnaeus University

Chun‐Hung Lin

National Cheng Kung University

Chun‐Hui Lin

National Taiwan Normal University

Zhijay Tu

Institute of Biological Chemistry, Academia Sinica

Sue‐Ming Chang

Institute of Biomedical Sciences, Academia Sinica

Hui‐Chang Lin

China Medical University

Chun‐Nan Lin

Kaohsiung Medical University

Cooperative Institutions

National Taiwan University

Institute of Biological Chemistry, Academia Sinica

Genomics Research Center, Academia Sinica

Academia Sinica

National Cheng Kung University

China Medical University

National Taiwan Normal University

Taipei Medical University

National Yang Ming Chiao Tung University

Kaohsiung Medical University

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ChemInform Abstract: Diastereoselective Conjugate Addition of Thiols to Camphor Pyrazolidinone Derived Chiral α,β-Unsaturated Carbonyls: Synthesis of β-Mercaptocarboxylic Acid Derivatives.

ChemInform (2000)

Chun‐Hui Lin Kung‐Shuo Yang Jia‐Fu Pan Kwunmin Chen

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Camphor

Conjugate

Addition reaction

10.1002/chin.200050120

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CCDC 259647: Experimental Crystal Structure Determination

The Cambridge Structural Database (2005)

Jia‐Fu Pan U. Venkatesham Kwunmin Chen

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/cc8q5qv

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ChemInform Abstract: Stereoselective Glycosylation of endo‐Glycals by Microwave‐ and AlCl₃‐Assisted Catalysis.

ChemInform (2011)

Hui‐Chang Lin Jia‐Fu Pan Yen‐Bo Chen Zi‐Ping Lin Chun‐Hung Lin

Abstract Microwave‐assisted glycosylation of endo‐glycals with various O‐nucleophiles proceeds smoothly in the presence of catalytic amounts of AlCl 3 to give 2‐deoxyglycosides, e.g. (III) or (V), with high α‐stereoselectivity.

10.1002/chin.201152191

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Structure and Mechanism of Helicobacter pylori Fucosyltransferase

Journal of Biological Chemistry (2007)

Han-Yu Sun Sheng‐Wei Lin Tzu‐Ping Ko Jia‐Fu Pan Chia-Ling Liu

Helicobacter pylori alpha1,3-fucosyltransferase (FucT) is involved in catalysis to produce the Lewis x trisaccharide, the major component of the bacteria's lipopolysaccharides, which has been suggested to mimic the surface sugars in gastric epithelium to escape host immune surveillance. We report here three x-ray crystal structures of FucT, including the FucT.GDP-fucose and FucT.GDP complexes. The protein structure is typical of the glycosyltransferase-B family despite little sequence homology. We identified a number of catalytically important residues, including Glu-95, which serves as the general base, and Glu-249, which stabilizes the developing oxonium ion during catalysis. The residues Arg-195, Tyr-246, Glu-249, and Lys-250 serve to interact with the donor substrate, GDP-fucose. Variations in the protein and ligand conformations, as well as a possible FucT dimer, were also observed. We propose a catalytic mechanism and a model of polysaccharide binding not only to explain the observed variations in H. pylori lipopolysaccharides, but also to facilitate the development of potent inhibitors.

Fucosyltransferase

Fucosylation

Sialyl-Lewis X

10.1074/jbc.m610285200

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Citations (123)

Rapid synthesis of oligomannosides with orthogonally protected monosaccharides

Chemical Communications (2012)

Sue‐Ming Chang Zhijay Tu Hau‐Ming Jan Jia‐Fu Pan Chun‐Hung Lin

We developed a facile synthesis to yield orthogonally protected mannose building blocks with high overall yields. The protection/glycosylation steps can be carried out in a successive manner without purification of intermediate products. This developed synthesis led to formation of linear/branched tri-, penta- and heptasaccharides.

Monosaccharide

10.1039/c2cc37099a

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Citations (14)

Diastereoselective conjugate addition of thiols to camphor pyrazolidinone derived chiral α,β-unsaturated carbonyls: synthesis of β-mercaptocarboxylic acid derivatives

Tetrahedron Letters (2000)

Chun‐Hui Lin Kung‐Shuo Yang Jia‐Fu Pan Kwunmin Chen

Camphor

Conjugate

Addition reaction

Michael reaction

10.1016/s0040-4039(00)01157-6