Mohamed A. Farag

Cairo University

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Paul W. Paré

Texas Tech University

John L. Capinera

University of Florida

Louis A. Somma

Florida State Collection of Arthropods

Spencer T. Behmer

Texas A&M University

Drion G. Boucias

University of Florida

Andrei Sourakov

University of Florida

Ian Stocks

Animal and Plant Health Inspection Service

Emmett R. Easton

University of Hawaiʻi at Mānoa

Murray B. Isman

University of British Columbia

Norma E. Sánchez

Sergio Arboleda University

Cooperative Institutions

Cairo University

168

National Research Centre

Ministry of Agriculture and Rural Affairs

American University in Cairo

Ain Shams University

Fujian Agriculture and Forestry University

University of Florida

Chinese Academy of Sciences

Alexandria University

National Water Research Center

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Elsevier eBooks (2025)

Asmaa S. Abd Elkarim Howaida I. Abd‐Alla Yasmina M. Abd‐Elhakim Mosaad A. Abdel‐Wahhab Wafaa F. Abusudah

10.1016/b978-0-443-21820-0.00002-7

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Citations (0)

UPLC-MS metabolome based classification of Lupinus and Lens seeds: A prospect for phyto-equivalency of its different accessions

Food Research International (2018)

Mohamed A. Farag Amira R. Khattab Amal A. Maamoun Matthias Kropf Andreas G. Heiss

Lupinus

Metabolome

Lupinus angustifolius

10.1016/j.foodres.2018.11.003

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Citations (54)

Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

Asian Pacific Journal of Tropical Biomedicine (2017)

Aisha Abou Zeid Mohamed A. Farag Manal A. Hamed Zeinab A. Kandil Radwa H. El‐Akad

To evaluate Brachychiton acerifolius leaf extracts as antidiabetic potential agent and to identify the main active constituents using bioactivity guided fractionation. In vitro antioxidant activity was evaluated for B. acerifolius different extracts using DPPH assay and vitamin C as control. Antidiabetic activity was then determined using STZ-induced rats treated daily with ethyl acetate and 70% ethanol leaf extracts for 4 weeks at a dose of 200 g/kg body weight against gliclazide reference drug. Blood glucose, α-amylase, lipid profile, liver function enzymes and oxidative stress markers were assessed along with histopathological study for liver and pancreatic tissues. Isolation and structural elucidation of active compounds were made using Diaion and Sephadex followed by spectral analyses. The results indicated that ethyl acetate and ethanol leaf extracts exhibited the strongest antioxidant activity compared to that of vitamin C (IC50 0.05, 0.03 and 12 mg/mL, respectively). Both extracts showed potent anti-hyperglycemic activity evidenced by a significant decrease in serum glucose levels by 82.5% and 80.9% and α-amylase by 45.2% and 53.6%, as compared with gliclazide 68% and 59.4%, respectively. Fractionation of ethanol extract resulted in the isolation of 9 flavonoids including apigenin-7-O-α-rhamnosyl(1→2)-β-d-glucuronide, apigenin-7-O-β-d-glucuronide, apigenin-7-O-β-d-glucoside and luteolin-7-O-β-d-glucuronide. This study highlights the potential use of B. acerifolius leaf extract enriched in flavones for the treatment of diabetes that would warrant further clinical trials investigation.

Gliclazide

10.1016/j.apjtb.2017.01.009

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Effects of tree age on flavonoids and antioxidant activity in Torreya grandis nuts via integrated metabolome and transcriptome analyses

Food Frontiers (2023)

Jingwei Yan Hao Zeng Weijie Chen Shan Zheng Jiali Luo

Abstract The nuts of Torreya grandis are abundant in flavonoids, providing potential antioxidant activity. Considering that T. grandis can yield nuts for hundreds or thousands of years, effects of tree age on flavonoids and antioxidant activity of T. grandis nuts were targeted in this study for the first time. Results revealed that antioxidant activity and total flavonoid contents in 100‐ and 1000‐years‐old T. grandis nuts were much higher compared to 10‐years‐old T. grandis . The content of 19 flavonoids showed significant correlations with antioxidant activity in 100‐ and 1000‐years‐old trees using metabolites profiling. Transcriptome and coexpression analysis indicated that seven genes were associated with aged‐related flavonoids biosynthesis. Further analysis showed that abscisic acid and gibberellin might regulate the age‐related differential flavonoids accumulation. Our study provides a novel viewpoint that aged T. grandis is likely to present a better source of natural antioxidants and has yet to be examined in other tree models.

Metabolome

10.1002/fft2.211

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Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC–MS, LC–MS and 1D NMR techniques

Phytochemistry (2012)

Mohamed A. Farag Andrea Porzel Ludger A. Wessjohann

Liquiritigenin

Glycyrrhiza

Isoliquiritigenin

Glycyrrhiza uralensis

Glycyrrhizin

Phytochemical

Metabolome

10.1016/j.phytochem.2011.12.010

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Citations (275)

Headspace Analysis of Volatile Compounds in Leaves from the Juglandaceae (Walnut) Family

Journal of Essential Oil Research (2008)

Mohamed A. Farag

Abstract Headspace volatile analysis coupled with software extraction of overlapping GC-seperated components was employed for volatiles profiling in leaves of six Juglans and Carya species. Qualitative and quantitative differences were observed among species. Sesquiterpenes dominated the volatile blend of all species (J. nigra L. 70%, J. cineara L. 61%, J. regia L. 47%, C. cordiformis, (Wangh.) K. Koch, 50%, C. laciniosa (Michx.) Loud. 41%, and C. illinoinensis (Wangh.) K. Koch 24%) with germacrene D occurring in the largest amount. Higher levels of monoterpenes were found in the headspace of J. cineara, J. regia and C. laciniosa leaves (35%, 24% and 18%, respectively). Among the benzenoids, methyl salicylate was found as the major leaf headspace component (J. regia 17 %, C. cordiformis 15%, C. laciniosa and C. illinoinensis 10%,).

Juglandaceae

Methyl salicylate

Germacrene D

10.1080/10412905.2008.9700023

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Citations (30)

Metabolomics driven analysis of artichoke leaf and its commercial products via UHPLC–q-TOF-MS and chemometrics

Phytochemistry (2013)

Mohamed A. Farag Sherweit H. El‐Ahmady Fatma S. Elian Ludger A. Wessjohann

Chemometrics

Cynara

Nutraceutical

10.1016/j.phytochem.2013.07.003

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Citations (98)

How Do Herbal Cigarettes Compare To Tobacco? A Comprehensive Review of Their Sensory Characters, Phytochemicals, and Functional Properties

ACS Omega (2022)

Rania T. Abdel Rahman Nurkhalida Kamal Ahmed Mediani Mohamed A. Farag

Herbal cigarettes, known as tobacco-free or nicotine-free cigarettes, are those recognized as being-tobacco free, being composed of a mixture of various herbs claimed to lessen the smoking habit hazards. However, controversial data regarding its properties occur in the literature with no comprehensive overview or analysis of its effects. Like herbal smokeless tobacco, they are often used to substitute for tobacco products (primarily cigarettes) regarded as a "nonsmoking" aid. This review capitalizes on herbal cigarettes with regard to their quality characteristics, sensory attributes, chemical composition, and health properties to rationalize their choice as a nonsmoking aid. Furthermore, the impacts of heat and/or pyrolysis that occur during smoking on its chemical composition are presented for the first time. Some herbal smokes may produce notable metabolic problems that increase the risk of several chronic metabolic diseases. In general, burning substances from plants can have a variety of negative effects on the body attributed to toxic chemicals such as carbon monoxide, polyaromatics, nicotine, and N-nitrosamines. This review compiles and discusses the phytochemical compositions detected in various herbal cigarettes alongside sensory and quality attributes and health effects.

Phytochemical

10.1021/acsomega.2c04708

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Citations (7)

The therapeutic potential for senescence-associated diabetes of green alga Enteromorpha prolifera polysaccharide

International Journal of Biological Macromolecules (2023)

Ruiyu Zhu Yuezhen Ouyang Yihan Chen Lizhu Zhang Jianping Nie

Senescence

Carbohydrate Metabolism

10.1016/j.ijbiomac.2023.123465

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Osteoprotective Activity and Metabolite Fingerprint via UPLC/MS and GC/MS of Lepidium sativum in Ovariectomized Rats

Nutrients (2020)

Hossam M. Abdallah Mohamed A. Farag Mardi M. Algandaby Mohammed Z. Nasrullah Ashraf B. Abdel‐Naim

Lepidium sativum seeds are used traditionally to accelerate healing of bone fracture in addition to its culinary uses. This study aimed to characterize the osteoprotective effect of L. sativum in an ovariectomized rat model at two dose levels (50 and 100 mg/kg) using 17β-estradiol as a positive reference standard. Moreover, a complete metabolite profile of L. sativum via UHPLC/PDA/ESI–MS, as well as headspace solid-phase microextraction (SPME)-GC/MS is presented. Results revealed that L. sativum extract exhibited significant anti-osteoporotic actions as evidenced by mitigating the decrease in relative bone weight concurrent with improved longitudinal and perpendicular femur compression strength. Further, the extract enhanced the serum bone formation biomarkers lactate dehydrogenase (LDH) activity and osteocalcin levels. The extract also inhibited exhaustion of superoxide dismutase (SOD) as well as glutathione peroxidase (GPx) activities and accumulation of lipid peroxides in bone tissues. This is in addition to ameliorating the rise in the markers of bone resorption carboxyterminal telopeptide, type I (CTXI) and tartrate-resistant acid phosphatase (TRAP) and modulating receptor activator of nuclear factor kappa-Β ligand (RANKL)/ osteoprotegerin (OPG) expression. Metabolite characterization suggests that glucosinolates, lignans, coumarins, phenolic acids, and alkaloids mediate these anti-osteoporotic effects in a synergistic manner.

Lepidium Sativum

Bone remodeling

10.3390/nu12072075

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Citations (20)